small molecule – Page 18 – Communicable Diseases Research

The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions

BioGRID 데이터베이스: 선별된 단백질, 유전 및 화학적 상호작용의 포괄적인 생물의학 자원

Tools for Protein Science

Published on 2020-11-232022-09-10
Journal: Protein Science : A Publication of the Protein Soc [Category] MERS, SARS, 변종,

CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-Target

Article

Published on 2020-11-182022-10-04
Journal: SLAS discovery : advancing life sciences R & D [Category] 신약개발, 치료제,

Potential Therapeutic Effect of Traditional Chinese Medicine on Coronavirus Disease 2019: A Review

Pharmacology

Published on 2020-11-092022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

Supporting SARS-CoV-2 Papain-Like Protease Drug Discovery: In silico Methods and Benchmarking

Chemistry

Published on 2020-11-052022-10-31
Journal: Frontiers in Chemistry [Category] COVID-19,

In silico molecular docking analysis for repurposing therapeutics against multiple proteins from SARS-CoV-2

Research article

Published on 2020-11-012022-10-05
Journal: European journal of pharmacology [Category] SARS, 신약개발,

[키워드] ACE2 addition angiotensin-converting enzyme 2 anti-inflammatory action antiviral drug approach approved drug bind binding binding energy can be used clinically COVID 19 COVID-19 docking drug Drug repurposing ENhance eriodictyol fatality globe HCQ Helicase Host Infection Interaction isoniazid Lopinavir molecular docking molecular docking analysis molecular interaction mycophenolic acid NSP pandemic Pemirolast Protein receptor Receptor binding domain researcher responsible SARS protein SARS-CoV-2 SARS-CoV-2 protein selected small molecule spike Spread supported target protein tested therapeutic treat Treatment understanding viral propagation virus was done
[DOI] 10.1016/j.ejphar.2020.173430 [Article Type] Research article

Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity

530

Published on 2020-10-272022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome animal model Antiviral antiviral activity antiviral drug Antiviral effect antiviral efficacy antiviral therapy Antiviral treatment baseline candidate Candidates clinical clinical trial Consensus Contact coronavirus COVID-19 COVID-19 patient COVID-19 patients dose drug effective Efficacy evaluate Evidence exhibit Favipiravir ferrets globe hamster hamsters High dose Human Hydroxychloroquine identify in vivo Infection infectious virus titer lack low dose lung Lung histopathology macaque Mild nontoxic preclinical model Prophylactic Prophylaxis protective effect reduced reduction in Repurposed drug required SARS-CoV-2 Significance significantly small molecule Spread suggested therapeutic toxic effects Transmission Treatment use of hydroxychloroquine viral disease virus virus levels virus transmission Wuhan
[DOI] 10.1073/pnas.2014441117 PMC 바로가기 [Article Type] 530

Phytogenic Products and Phytochemicals as a Candidate Strategy to Improve Tolerance to Coronavirus

Veterinary Science

Published on 2020-10-202022-11-01
Journal: Frontiers in Veterinary Science [Category] COVID-19,

[키워드] acute respiratory syndrome antiviral activities antiviral activity Antiviral compound bronchitis caffeic acid candidate carried caused compounds Concentration coronavirus coronavirus disease Coronaviruses cough COVID-19 COVID-19 pandemic death Fever fused Health herbal medicine humans IBV Immunity include Infection Infectious disease influences on inhibit inhibitor inhibitory knowledge lack majority medication MERS Middle East negative influence outbreak phytochemical phytochemicals phytogenic additive plants plasma polar product proliferation quercetin researcher SARS-CoV-2 Side effects small molecule sore throat spread of COVID-19 strain Strategy structures Symptom syndrome Treatment viral infections virus with COVID-19
[DOI] 10.3389/fvets.2020.573159 PMC 바로가기 [Article Type] Veterinary Science

Molecular docking study of potential phytochemicals and their effects on the complex of SARS-CoV2 spike protein and human ACE2

Article

Published on 2020-10-192022-10-04
Journal: Scientific Reports [Category] MERS, SARS, 치료제,

Desperate Times, Desperate Measures: The Case for RRx-001 in the Treatment of COVID-19

절박한 시간, 절박한 조치: COVID-19 치료에서 RRx-001 사례

Article

Published on 2020-10-012022-09-11
Journal: Seminars in oncology [Category] SARS, 신약개발,

[키워드] activate acute respiratory distress acute respiratory distress syndrome acute respiratory symptom acute respiratory symptoms acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 appear approved bosentan Cancer caused Cell chronic obstructive chronic obstructive pulmonary disease clinical clinical trial clinical trials comparable coronavirus Course COVID 19 COVID-19 cytokine Cytokine storm death Deterioration Donor effective evaluated Evidence evidence of expected FDA hypertension Hypothesis ICU immune cascade Infection Inflammatory initiated less lung cancer lung cancer patient Lung infection mechanism of action Mild mild upper respiratory tract infection nitric oxide obstructive pulmonary disease oxidative pandemic Pathogenesis Patient phase phase 3 clinical trial Pneumonia preclinical studies preclinical study prodrome protective effect pulmonary disease pulmonary hypertension Pulmonary infection radiological respiratory respiratory distress Respiratory distress syndrome respiratory tract infection RRx-001 SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe pneumonia small molecule smoking syndrome the disease therapeutic activity transfer treat treated Treatment Trial upper respiratory tract upper respiratory tract infection
[DOI] 10.1053/j.seminoncol.2020.07.002 PMC 바로가기 [Article Type] Article

ACE2 in the Era of SARS-CoV-2: Controversies and Novel Perspectives

Molecular Biosciences

Published on 2020-09-302022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] “cytokine storm” accumulates ACE ACE inhibitor ACE2 ACE2 expression ACE2 protein ACE2 receptor acute respiratory syndrome Administered Alter Angiotensin receptor blockers angiotensin-converting enzyme 2 antibodies appear binding biochemical Biochemistry cardioprotection cardiovascular system cellular clinical investigation competitive binding COVID-19 COVID-19 disease COVID-19 pandemic Cytokine storm determinant downregulation drugs Effect effort engage enzyme Epigenetic event Evidence exogenously forms glycosylation Host host cell membrane hypertension induce Infection initial Interaction intestine kidney knowledge limit Lung inflammation mammalian mechanism Medical conditions MicroRNAs modulation Neutralizing novel observation pathogenicity pathophysiological pathophysiology peptides Phosphorylation plasma membrane Protein reduce reduced regulated Replication respiratory tract responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 severe COVID-19 small molecule Spike protein Strategy subunits: S1 tissues transcriptional viral envelope viral genome virus virus entry
[DOI] 10.3389/fmolb.2020.588618 PMC 바로가기 [Article Type] Molecular Biosciences