Searching for COVID-19 Antibodies in Czech Children—A Needle in the HaystackPediatrics Published on 2020-11-122022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] acute respiratory syndrome age antibodies antibody Antibody Response Asymptomatic caused children coronavirus COVID-19 Czech Republic Frequency help hospital infected children mapping Mild symptom needle Pandemics pediatric Prague Prevalence Protective SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 seroprevalence screened seropositive subject Seroprevalence shown tested the disease the SARS-CoV-2 Therapeutic strategies virus zero [DOI] 10.3389/fped.2020.597736 PMC 바로가기 [Article Type] Pediatrics
Age-severity matched cytokine profiling reveals specific signatures in Covid-19 patientsArticle Published on 2020-11-062022-10-04 Journal: Cell Death & Disease [Category] SARS, 치료기술, [키워드] circulating Clinical management clinical outcomes COVID-19 COVID-19 pandemic COVID-19 patients critical COVID-19 patients CXCL8 cytokine defined described disease severity effort Factor Hospitalization hospitalized patient identify IL-10 IL-15 IL-27 Immune profile immune profiling immune signature Immunity inflammatory mediator investigated key factor lymphopenia morbidity and mortality Older age Patient Predictive markers reveal SARS-CoV-2 Severe case T-cell exhaustion the disease Therapeutic strategies TNF-α Translational research understanding [DOI] 10.1038/s41419-020-03151-z PMC 바로가기 [Article Type] Article
Targeting ferroptosis in breast cancer유방암의 ferroptosis 표적화Review Published on 2020-11-052022-08-13 Journal: Biomarker Research [Category] Biochemistry, [키워드] accelerate accumulation Affect Biomarker Breast cancer Cancer caused Crosstalk expression Ferroptosis Ferroptotic regulators Historical perspective metabolism Occurrence Previous studies Regulated cell death ROS sensitivity subtype targeting Therapeutic strategies therapeutic strategy therapeutic target [DOI] 10.1186/s40364-020-00230-3 PMC 바로가기 [Article Type] Review
COVID-19 and Systemic Lupus Erythematosus: Focus on Immune Response and TherapeuticsCOVID-19 및 전신성 홍반성 루푸스: 면역 반응 및 치료에 초점Review Published on 2020-10-302022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] aberrant immune response affected Anti-viral Antiviral autoantibodies Autoimmune disease Better cause caused characterized circulating Clinical outcome clinical outcomes Comorbidities Coronavirus infection Coronaviruses COVID-19 COVID-19 pandemic cytokine Cytokine storm Cytokines damage death Defense Disease progression Ethnicity focus immune response Immune-mediated in viral individual Infection Infectious disease lead lung Lungs Lupus lupus erythematosus lymphopenia management mechanisms morbidity and mortality Novel coronavirus other organs Patient patients Population populations progression Proinflammatory cytokine proinflammatory cytokines PROTECT Regulatory response SARS-CoV-2 severity susceptible systemic systemic lupus erythematosus T cells the disease Therapeutic strategies therapeutic strategy Therapeutics tissues treated underlying condition underlying conditions vice Viral viral infections while [DOI] 10.3389/fimmu.2020.589474 PMC 바로가기 [Article Type] Review
Renin–Angiotensin System: An Important Player in the Pathogenesis of Acute Respiratory Distress SyndromeReview Published on 2020-10-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE ACE2 Activation activity acute lung injury addition Appropriate ARDS attenuate cell entry cells changes in characterized COVID-19 Defense distress drug effective enzyme help humoral increased vascular permeability Inflammation Initially Injury lack pathogen’ Pathogenesis Pathogens Prognosis Pulmonary edema pulmonary fibrosis question RAS reducing renin–angiotensin system respiratory SARS-CoV-2 SARS-CoV-2 pandemic soluble ACE2 subject survival syndrome Therapeutic strategies therapeutic strategy tissue repair Treatment tumor necrosis factor-α [DOI] 10.3390/ijms21218038 PMC 바로가기 [Article Type] Review
A 21st Century Evil: Immunopathology and New Therapies of COVID-1921세기의 악: 면역병리학과 코로나19의 새로운 치료법Review Published on 2020-10-272022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory distress addition affecting alterations angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approved drug breathing difficulty caused cellular exhaustion Comorbidities contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokine storm Cytokine storms death demonstrated difficulty disease effective Fever host immune system immune system immunopathological immunopathology Immunotherapy infected patient infected patients Infection inflammatory monocyte inflammatory monocytes Interaction involved killing Lungs Lymphocytes lymphopenia macrophages mechanism Monocytes New older patient older patients organs receptor respiratory respiratory distress respiratory tract SARS-CoV-2 SARS-CoV-2 virus severe acute respiratory syndrome coronavirus 2 severity specific treatment Spread Symptom the disease the SARS-CoV-2 virus therapeutic approaches Therapeutic strategies Treatment Wuhan Wuhan, China [DOI] 10.3389/fimmu.2020.562264 PMC 바로가기 [Article Type] Review
Neurobiochemical Cross-talk Between COVID-19 and Alzheimer’s DiseaseCOVID-19와 알츠하이머병 사이의 신경생화학적 누화Review Published on 2020-10-192022-09-12 Journal: Molecular neurobiology [Category] MERS, SARS, 진단, [키워드] ACE2 allele Alzheimer’s disease angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 APOE4 ApoE4 allele association CKAP4 cofactor common COVID-19 cytoskeleton described disease enzyme etiological Factor Gal-9 Galectin-9 IL-1 IL-6 Inflammation interleukin interleukin-1 manifestation Manifestations marker medication memory Neuroinvasive pro-inflammatory pro-inflammatory markers Protein receptor risk Therapeutic approach therapeutic approaches Therapeutic strategies therapeutic strategy understanding urgency [DOI] 10.1007/s12035-020-02177-w PMC 바로가기 [Article Type] Review
Host–Viral Interactions Revealed among Shared Transcriptomics Signatures of ARDS and Thrombosis: A Clue into COVID-19 PathogenesisOriginal Article Published on 2020-10-172022-10-29 Journal: TH Open: Companion Journal to Thrombosis and Haemostasis [Category] COVID-19, [키워드] Activation acute respiratory distress Anticoagulant ARDS Biotechnology Coagulation coagulation factor Combination conducted Convolution COVID-19 COVID-19 pathogenesis COVID-19 patients database dataset datasets DEGs DHX9 differentially expressed gene disease effect size endothelial damage enrichment analysis expression data Gene Expression Helicase highly pathogenic host–virus interaction implication IMPROVE Infection Inflammation KAT2B low molecular weight lung lysine management mechanism Meta-analysis NCBI-GEO network novel corona virus observation Pathway enrichment analysis Pathways Protein PSMB2 random effect RBX1 RELA Replication Revealed SARS-CoV-2 Sepsis shown signature subsequent subunit suggested syndrome Therapeutic strategies thrombosis thrombotic TP53 transcriptomics Treatment Venous Thromboembolism virus VTE was done was used were used worsened [DOI] 10.1055/s-0040-1721706 PMC 바로가기 [Article Type] Original Article
SARS-CoV-2 mediated lung inflammatory responses in host: targeting the cytokine storm for therapeutic interventionsReview Published on 2020-10-162023-06-15 Journal: Molecular and cellular biochemistry [Category] MERS, SARS, [키워드] And antibody-dependent enhancement COVID-19 Cytokine storm Lung inflammation SARS-CoV-2 Therapeutic strategies [DOI] 10.1007/s11010-020-03935-z PMC 바로가기 [Article Type] Review
Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure Research Published on 2020-10-052022-10-05 Journal: Nature Genetics [Category] 변종, [키워드] accumulate Analysis Cancer Chromatin structure dataset distribution domains Factor generate Genome genome organization human cancers inactive Mutation mutational processe mutational processes Replication somatic mutation Therapeutic strategies understanding Variation whole-genome [DOI] 10.1038/s41588-020-0708-0 [Article Type] Research