In silico mutagenesis of human ACE2 with S protein and translational efficiency explain SARS-CoV-2 infectivity in different speciesS 단백질을 사용한 인간 ACE2의 in silico 돌연변이 유발 및 번역 효율성은 다른 종의 SARS-CoV-2 감염성을 설명합니다Research Article Published on 2020-12-072022-08-13 Journal: PLoS Computational Biology [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 variant ACE2 variants addressed affecting affinity allelic Amino acid angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 binding cats caused cellular entry coronavirus coronavirus disease coronavirus disease COVID-19 Coronavirus infection COVID-19 pandemic death difference domain early stage Efficiency enzyme explain expression level expression levels Factor Factors feature ferrets Genomic variability hACE2 host protein host proteins Human human ACE2 human angiotensin converting enzyme 2 human cell human cells humans immune response in silico in some in viral individual infect Infection integration Interaction interface mice modify Mutagenesis new virus pandemic PIGS protein-protein interaction proteome RBD domain recognize reported S protein SARS-CoV-2 SARS-CoV-2 virus second sensitivity sequence species Spike protein stability the RBD the SARS-CoV-2 translated translation translational tRNA Variability variant Viral viral infectivity viral mutation Viral protein Viral proteins virus virus isolate waters [DOI] 10.1371/journal.pcbi.1008450 PMC 바로가기 [Article Type] Research Article
Efforts at COVID-19 Vaccine Development: Challenges and SuccessesReview Published on 2020-12-062022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acquisition applied approval candidate challenge circulating clinical trials CoV COVID-19 COVID-19 disease disadvantage Efficacy Efficiency effort Epidemiology Europe evaluate globe Health manuscript New coronavirus Pandemics produced public health public health emergency SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spread stages translational trials Vaccine Vaccine development vaccine platform Vaccines virus [DOI] 10.3390/vaccines8040739 PMC 바로가기 [Article Type] Review
Hydroxychloroquine as Prophylaxis for COVID-19: A ReviewPharmacology Published on 2020-12-032022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] approach approved available data Clinical data clinical setting clinical trial clinical trials conducted COVID-19 COVID-19 pandemic disease drug effective effective drug effort examined expired HCQ HCW healthcare worker highlighting Hydroxychloroquine identify in vitro data include indicate lack Loading dose majority methodological Phase 3 Placebo preclinical data promote Prophylactic Prophylaxis Randomized randomized studies recruit Repository resource review Scientific community Standard of care subject Toxicity translational Treatment Trial Vaccines [DOI] 10.3389/fphar.2020.605185 PMC 바로가기 [Article Type] Pharmacology
Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across speciesResearch article Published on 2020-12-012022-10-05 Journal: Neurobiology of Learning and Memory [Category] 비임상, [키워드] Abstract addition ADHD Alter anti-inflammatory action Attention benefit Brain cognitive cortical deficit dendritic Effect Evidence executive expand explain function functions Guanfacine inhibit Injury Intuniv mechanism of action memory Mental disorder Mental Disorders microglia modulation neuronal NMDAR Norepinephrine off-label plasticity Potassium reducing Research Schizophrenia selective Signaling Stress stress-related disorder synaptic therapeutic action translation translational variety Working memory α2A-adrenoceptor [DOI] 10.1016/j.nlm.2020.107327 [Article Type] Research article
Phylogenomics Analysis of SARS-CoV2 Genomes Reveals Distinct Selection Pressure on Different Viral StrainsResearch Article Published on 2020-11-272022-10-27 Journal: BioMed Research International [Category] Coronavirus, MERS, SARS, [키워드] Analysis carried codon correlated evaluated genetic diversity Genome genomic Genomic analysis globe indicate mutational bia mutational rate natural selection nine Novel coronavirus nucleotide substitution outbreak Phylogenomics Positive selection pressure SARS-CoV2 SARS-CoV2 genome SARS-CoV2 genomes Selection selection pressure Site strain translational viral genomes viral strain [DOI] 10.1155/2020/5746461 PMC 바로가기 [Article Type] Research Article
The clinical and translational research activities at the INT – IRCCS “Fondazione Pascale” cancer center (Naples, Italy) during the COVID-19 pandemicMethodology Published on 2020-11-232022-10-30 Journal: Infectious Agents and Cancer [Category] COVID-19, [키워드] activity ARDS Cancer Cancer center cancer patient Cancer patients Care China chronic disease Clinical course conditions COVID-19 COVID-19 pandemic death diabetes disease distress Europe Health home quarantine Hospitalization Hospitalized host response IL-6 INT IRCCS Italy molecular mechanism Naple Naples North Nurses older subjects oncology outbreak oxygen saturation Pascale Patient patients patients died performed Physicians positive professional reported required Research researchers SARS-CoV-2 Severe case South America subject Surveillance symptomatic syndrome tested Tocilizumab transfer translational Treatment [DOI] 10.1186/s13027-020-00330-7 PMC 바로가기 [Article Type] Methodology
Stress test: translational research during COVID‐19 pandemicEditorial Published on 2020-11-182022-10-29 Journal: Journal of Cachexia, Sarcopenia and Muscle [Category] Coronavirus, MERS, SARS, [키워드] COVID‐19 pandemic Research translational [DOI] 10.1002/jcsm.12640 PMC 바로가기 [Article Type] Editorial
Improving target assessment in biomedical research: the GOT-IT recommendations Reviews Published on 2020-11-162022-10-05 Journal: Nature Reviews Drug Discovery [Category] 바이오마커, 치료제, [키워드] activity clinical development clinical trials conducted Critical disease drug candidate drugs effort facilitate facilitated Factor identify Improving modulation question recommendation Research robust stimulate Support target targets Therapies translational [DOI] 10.1038/s41573-020-0087-3 [Article Type] Reviews
Organoid based personalized medicine: from bench to bedsideReview Published on 2020-11-022022-10-31 Journal: Cell Regeneration [Category] COVID-19, [키워드] accumulating addition application Biobanks Cancer CRISPR-Cas9 disease modeling Diseases Evidence fibrosis Genetic in vitro in vivo malignant diseases Organoid organoids organs Personalized medicine phenotypic pluripotent stem cell regenerative Research stem cell stem cells tissues translational [DOI] 10.1186/s13619-020-00059-z PMC 바로가기 [Article Type] Review
COVID-19 and islet transplantation: Different twinsCOVID-19와 섬 이식: 다른 쌍둥이Review Published on 2020-11-012022-09-11 Journal: American journal of transplantation : official jou [Category] SARS, 바이오마커, [키워드] Activation advancement approaches Blood can not clinical decision-making clinical trial Clinical trial design clinical trials Coagulation coagulation cascade complement complement system complement system activation contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 treatment Cytokines cytokines/cytokine receptors detrimental editorial/personal viewpoint event identification immune immune regulation Infection infection and infectious agents - viral infectious agent infectious agents Infectious disease Inflammation Inflammatory inflammatory reaction Innovation islet islet transplantation islet transplantation. legacy liver lung Obstructive organization patients proinflammatory recognize referred to Scientific community similarities similarity syndrome targeting These data translational vessel [DOI] 10.1111/ajt.16001 PMC 바로가기 [Article Type] Review