Genome evolution of SARS-CoV-2 and its virological characteristicsReview Published on 2020-08-102022-10-30 Journal: Inflammation and Regeneration [Category] COVID-19, [키워드] Analysis bat Characteristics China Comparative genomics coronavirus COVID-19 deaths described disease Evolution of SARS-CoV-2 genome sequence Genome sequence data genomic GISAID database Mild other coronaviruses pangolin Phylogeny Pneumonia prevalence of COVID-19 related viruses reported required SARS-CoV SARS-CoV-2 Symptom the disease viral evolution Virological virus [DOI] 10.1186/s41232-020-00126-7 PMC 바로가기 [Article Type] Review
Construction of SARS-CoV-2 Virus-Like Particles by Mammalian Expression SystemBioengineering and Biotechnology Published on 2020-07-302022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] construction COVID-19 disease expression Genetic glycosylation patterns HEK-293T cells lack mammalian membrane protein molecular Morphological morphological feature non-infectious Pandemics Particle Particles pathogenic viruses powerful tool Protein Release Research Safe SARS-CoV-2 SARS-CoV-2 VLP SARS-CoV-2 VLPs self-assemble shown small envelope structural proteins System vaccine candidate Vero E6 cell virion Virological virus virus-like particles VLP [DOI] 10.3389/fbioe.2020.00862 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody강력한 치료 항체에 의한 SARS-CoV-2 및 SARS-CoV의 중화를 위한 구조적 기반Report Published on 2020-07-232022-09-14 Journal: Science (New York, N.y.) [Category] Fulltext, SARS, 비임상, 진단, [키워드] administration against SARS-CoV Analysis antibody approved caused cellular complex conformational COVID-19 COVID-19 pandemic cross-protective demonstrated epitope Epitopes Fab fragment hACE2 highlight host cell humanized monoclonal antibody lung neutralization neutralize neutralizing antibody Prevent prevented pseudovirus public health crisis Pulmonary pathology RBD Receptor binding domain receptors reduced reported S trimer SARS-CoV SARS-CoV-2 the RBD the SARS-CoV-2 the SARS-CoV-2 virus therapeutic therapeutic intervention treating COVID-19 Treatment Vaccine Virological [DOI] 10.1126/science.abc5881 PMC 바로가기 [Article Type] Report
Basic epidemiological parameter values from data of real-world in mega-cities: the characteristics of COVID-19 in Beijing, ChinaResearch Article Published on 2020-07-202022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] age analyzed asymptomatic infections average basic basic reproduction number Beijing Characteristics China circulation close contact Community confirmed case COVID-19 disease epidemiological Epidemiology Evidence Genetic variant HCWs healthcare worker infected case mean incubation period parameter Patient positive public health real-world data Result SARS-CoV-2 secondary attack rate social contact Spread the median Transmissibility transmissibility of SARS-CoV-2 Virological widespread Wuhan [DOI] 10.1186/s12879-020-05251-9 PMC 바로가기 [Article Type] Research Article
Transplacental transmission of SARS-CoV-2 infectionArticle Published on 2020-07-142022-10-04 Journal: Nature Communications [Category] SARS, 진단, [키워드] clinically congenital demonstrated described Evidence histological immunohistochemistry Infection Infectious diseases Inflammation mother Neonatal neurological neurological manifestations outbreak paediatrics pandemic patients placental Placental infection presenting SARS-CoV-2 SARS-COV-2 infection shown Transmission transmission of SARS-CoV-2 transmission route transmitted transplacental transmission Viremia Virological [DOI] 10.1038/s41467-020-17436-6 PMC 바로가기 [Article Type] Article
The Australasian COVID-19 Trial (ASCOT) to assess clinical outcomes in hospitalised patients with SARS-CoV-2 infection (COVID-19) treated with lopinavir/ritonavir and/or hydroxychloroquine compared to standard of care: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-07-142022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 48 hour addition Administered adverse effect allergy Alpha anticipated assumed baseline blinded to treatment block clinical Clinical outcome Comorbidity COVID-19 data management Day death determine dissemination drug interaction element eligible eligible participant enrolment evaluate evaluated excluded expected group hospital hospitalised hospitalised patient Hydroxychloroquine independent Intensive intensive care Intervention intervention arms invasive investigator investigator-initiated Laboratory Lopinavir management men New no interaction non-invasive ventilation nucleic acid number objective Open-label outcome participant Patient platform Primary outcome proportion Proportion of participant protocol provided QTC prolongation randomisation randomised randomised controlled trial receive receiving recruited reduce Registered registry representing required researcher Respiratory Support risk Ritonavir Sample size SARS-CoV-2 SARS-COV-2 infection secondary outcome sequence significance level Standard of care status stratified study drug Study protocol Tablet total sample size treated Trial two-sided unblinding ventilatory support Virological website women [DOI] 10.1186/s13063-020-04576-9 PMC 바로가기 [Article Type] Letter
Comparison of hydroxychloroquine, lopinavir/ritonavir, and standard of care in critically ill patients with SARS-CoV-2 pneumonia: an opportunistic retrospective analysisResearch Published on 2020-07-112022-11-01 Journal: Critical Care [Category] COVID-19, [키워드] acute respiratory syndrome Admission changes in Characteristics Clinical data compassionate use Coronavirus-2 Critically ill patient critically ill patients Cycle threshold value demonstrated drug Effect Efficacy Escalation Extra-corporeal membrane oxygenation group groups Hydroxychloroquine in viral intensive care unit intubation Lopinavir/ritonavir Mortality no difference no significant difference occurred outbreak outcome Patient plasma Pneumonia Primary outcome proportion Randomized controlled trial renal replacement therapy required respiratory tracts Result Retrospective analysis SARS-CoV-2 secondary specific treatment Standard of care Support therapeutic options treated Treatment ventilator-free day Viral load Virological [DOI] 10.1186/s13054-020-03117-9 PMC 바로가기 [Article Type] Research
Advances and challenges in the prevention and treatment of COVID-19Review Published on 2020-07-092022-10-29 Journal: International Journal of Medical Sciences [Category] COVID-19, MERS, SARS, [키워드] advance caused Characteristics Clinical treatment coronavirus Coronavirus pneumonia COVID-19 drug drugs epidemiological explained information introduced MERS-CoV Middle East New coronavirus outbreak Prevent provided respiratory SARS-CoV SARS-CoV-2 treat Treatment Virological virological characteristics [DOI] 10.7150/ijms.47836 PMC 바로가기 [Article Type] Review
Immunological and inflammatory profiles in mild and severe cases of COVID-19Article Published on 2020-07-082022-10-04 Journal: Nature Communications [Category] SARS, 치료기술, 치료법, [키워드] Activation Acute inflammation CD4+ T cells CD8+ T cell clinical expression COVID-19 COVID-19 patient cytotoxicity defined distribution dysregulation epidemiological Express expression fatality feature hospitalized patient Immune cell Immune profile Immunophenotyping Infection infiltration Inflammatory inhibitory lung tissue lymphopenia macrophages management marker Mild Mortality NK cells occur outcome Pathogenesis pathogenesis of SARS-CoV-2 Patient patients with COVID-19 profile SARS-CoV-2 RNA selective Severe case severe COVID-19 disease severe COVID-19 patients severe disease subset T cell T-cell T-cell activation target therapeutic intervention Treatment viral infection Virological with COVID-19 with mild disease [DOI] 10.1038/s41467-020-17240-2 PMC 바로가기 [Article Type] Article
Asymptomatic and Symptomatic Patients With Non-severe Coronavirus Disease (COVID-19) Have Similar Clinical Features and Virological Courses: A Retrospective Single Center StudyMicrobiology Published on 2020-06-262022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] analyzed association Asymptomatic asymptomatic patient bilateral pneumonia center Chest computed tomography Chest CT Chinese clinical clinical feature Clustering coronavirus disease Course COVID-19 COVID-19 patient CT scan defined demographic evaluate Follow-up had more had no hospital initial laboratory-confirmed less outbreak pandemic Patient patients Pneumonia Probability progression retrospective SARS-CoV-2 single center symptomatic symptomatic patient Symptomatic patients symptomatic status the disease Transmission treated Virological without symptom World Health Organization Wuhan, China [DOI] 10.3389/fmicb.2020.01570 PMC 바로가기 [Article Type] Microbiology