Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker?Research Article Published on 2016-05-032022-10-27 Journal: BioMed Research International [Category] Coronavirus, MERS, [키워드] addition asymptomatic infections candidate cause clone coronavirus demonstrated fatal disease Feline infectious peritonitis genetic diversity genetic marker M gene marker mutant spectrum producing Protein responsible sequenced strain suggested unique virulent virus widespread [DOI] 10.1155/2016/8560691 PMC 바로가기 [Article Type] Research Article
Epidemic strain YC2014 of porcine epidemic diarrhea virus could provide piglets against homologous challengeResearch Published on 2016-04-222022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] acute diarrhea aligned Amino acid Analysis antigenic antigenicity caused China classical colostrum Complete control vaccine Critical demonstrated diarrhea effective Efficiency Epidemic epidemic diarrhea Epidemic strain Evidence genomic sequence homologous identity immune Immune protective efficiency immunized inactivated indicate insertion intestinal isolate Isolation neutralizing antibody Neutralizing antibody titer nucleotide nucleotide deletion nucleotide sequence occurred outbreak pathogenic PEDV Porcine epidemic diarrhea virus PROTECT Protective Result S gene sequence sera significantly higher Strains Symptom Vaccine variants Variation virulent virus [DOI] 10.1186/s12985-016-0529-z PMC 바로가기 [Article Type] Research
Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease InhibitorResearch Article Published on 2016-03-302022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 3CLpro Animal coronaviruses Antiviral compound antiviral drug antiviral drugs Antiviral treatment cause caused cell tropism contributed coronavirus Coronavirus infection Coronavirus infections Cross-species transmission death disease Diseases effective Efficacy and safety evaluated experimental evidence facilitate fatal disease fatality feature Feline infectious peritonitis Fever full recovery Health Host Human humans immune response Immune-mediated infect inflammatory disease inhibitor Laboratory less lymphopenia mammalian measure Mild Mutation other coronavirus pathogen Pathogenesis progression protease Protease inhibitor recombination rate reduction in Replication reported required respiratory resulting returned reversal risk Significant T cells therapeutic therapeutic efficacy therapeutic strategy tissue Treatment viable treatment viral titer virulence virulent virus virus replication [DOI] 10.1371/journal.ppat.1005531 PMC 바로가기 [Article Type] Research Article
Experimental infection of a US spike-insertion deletion porcine epidemic diarrhea virus in conventional nursing piglets and cross-protection to the original US PEDV infectionResearch Article Published on 2015-11-202022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] anorexia Antigen Clinical signs cross-protection diarrhea epidemic diarrhea Factor fecal Health Infection inoculated intestinal lactation less morbidity Mortality Multiple studies negative controls PEDV positive provided RNA severity strain subset virulence virulent virus watery [DOI] 10.1186/s13567-015-0278-9 PMC 바로가기 [Article Type] Research Article
Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable VaccineResearch Article Published on 2015-10-292022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] addition against SARS-CoV analyzed biosafety carboxy-terminal region causing Cell culture chimeric contributed coronavirus Coronaviruses CoVs deleted Deletion duplication E gene E protein effective epidemic diarrhea full-length Genetic Host identification immune response in vitro in vivo indicated induce insertion interferon response introduced Live attenuated vaccine manuscript mechanism membrane MERS-CoV mice Middle East molecular mechanism morbidity and mortality motif mutant virus mutated Mutation not affect parental passage pathogenicity PEDV phenotype Protective Protein provided recombinant remained restored resulting reversion Safe SARS-CoV SARS-CoV vaccine sequence stability STABLE syndrome the vaccine therapy transmembrane protein understanding Vaccine vaccine candidate Vaccines variant virulence virulent virus virus attenuation virus genome [DOI] 10.1371/journal.ppat.1005215 PMC 바로가기 [Article Type] Research Article
Effect of Porcine Epidemic Diarrhea Virus Infectious Doses on Infection Outcomes in Naïve Conventional Neonatal and Weaned PigsResearch Article Published on 2015-10-062022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Antibody Response caused cell culture medium Clinical signs condition Conventional cycle threshold determine Effect epidemic diarrhea group Histopathology immunohistochemistry Infection infectious dose infectious titer information inoculated medium naïve Neonatal Neonate observation PCR PEDV pig polymerase chain significantly lower Spread TCID the United State virulent virus [DOI] 10.1371/journal.pone.0139266 PMC 바로가기 [Article Type] Research Article
Suppression subtractive hybridization method for the identification of a new strain of murine hepatitis virus from xenografted SCID miceOriginal Article Published on 2015-09-082022-10-28 Journal: Archives of Virology [Category] Coronavirus, MERS, [키워드] absence association clone combined immunodeficiency comparison coronavirus determinant Driver cDNA Frame genome sequence genomic sequence Hepatitis identify Langerhans cell histiocytosis liver mice murine murine hepatitis virus new strain new virus nucleotide sequence PCR predicted Protein protein level retroviral retrovirus SCID Mouse sequence sequenced Subtract cDNA Library suppression Suppression Subtractive Hybridization Tester cDNA tissues unique virulent virus virus strain was used whole genome [DOI] 10.1007/s00705-015-2592-y PMC 바로가기 [Article Type] Original Article
Genetic Characterization of the Belgian Nephropathogenic Infectious Bronchitis Virus (NIBV) Reference Strain B1648Communication Published on 2015-08-072022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] accessory protein Amino acid Analysis B1648 Belgium characterization chicken circulating Complete complex determinant Europe Evolution Factor full-length genome Genetic genomes Genotype Gray highest IBV identify indicated Infectious Bronchitis Virus Intensive M protein Massachusett nephropathogenic NGS nonstructural protein North Open reading frame ORF ORFs Phylogenetic analysis predicted reference reported sequence sequence homology Sequencing Spike protein strain Strains transcriptase vaccination variant virulent was determined [DOI] 10.3390/v7082827 PMC 바로가기 [Article Type] Communication
Rapid Emergence of Highly Pathogenic Avian Influenza Subtypes from a Subtype H5N1 Hemagglutinin VariantArticle Published on 2015-05-012023-05-31 Journal: Emerging Infectious Diseases [Category] Fulltext, 조류인플루엔자, [키워드] Avian Influenza clade 2.3.4 Evolution H5N1 hemagglutinin highly pathogenic HPAI Influenza monophyletic group rapid emergence reassortant reassortment events subtype variant virulent viruses [DOI] 10.3201/eid2105.141927 PMC 바로가기
Comparison of Porcine Epidemic Diarrhea Viruses from Germany and the United States, 2014Dispatch Published on 2015-03-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] caused determine disease epidemic diarrhea Europe European isolates Genome German case report Germany new variant Next-generation sequencing Porcine epidemic diarrhea virus strain The United States variant virulent virus viruses [DOI] 10.3201/eid2103.141165 PMC 바로가기 [Article Type] Dispatch