Helmet continuous positive airway pressure versus high-flow nasal cannula in COVID-19: a pragmatic randomised clinical trial (COVID HELMET)COVID-19에서 헬멧 연속 양압기 대 고유량 비강 캐뉼러: 실용적인 무작위 임상 시험(COVID HELMET)Randomized Controlled Trial Published on 2020-12-032022-09-10 Journal: Trials [Category] MERS, SARS, 임상, 치료기술, [키워드] 1:1 90% power clinical trial COVID COVID-19 COVID-19 cohort COVID-19 epidemic CPAP detect End-Expiratory Pressure Evidence feasible Helmet CPAP HFNC High-flow nasal cannula hypothesise hypoxaemia implication International intubation Invasive mechanical ventilation investigator investigator-initiated low-flow oxygen therapy Mann-Whitney U test nasal nasal cannula oxygen Oxygen therapy Patient patient recruitment PEEP positive airway pressure Positive end-expiratory pressure Pragmatic Primary outcome randomised Randomised controlled trial protocol Randomised trial reduce required Sample size significance level survival treated Trial registration ventilator free day ventilator free days Ventilator-free days VFD with COVID-19 [DOI] 10.1186/s13063-020-04863-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
Hydroxychloroquine as Prophylaxis for COVID-19: A ReviewPharmacology Published on 2020-12-032022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] approach approved available data Clinical data clinical setting clinical trial clinical trials conducted COVID-19 COVID-19 pandemic disease drug effective effective drug effort examined expired HCQ HCW healthcare worker highlighting Hydroxychloroquine identify in vitro data include indicate lack Loading dose majority methodological Phase 3 Placebo preclinical data promote Prophylactic Prophylaxis Randomized randomized studies recruit Repository resource review Scientific community Standard of care subject Toxicity translational Treatment Trial Vaccines [DOI] 10.3389/fphar.2020.605185 PMC 바로가기 [Article Type] Pharmacology
Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models하이드록시클로로퀸 예방 및 치료는 원숭이와 햄스터 SARS-CoV-2 질병 모델에서 효과가 없습니다Research Article Published on 2020-12-032022-09-10 Journal: JCI Insight [Category] MERS, SARS, 신약개발, 진단, 치료제, [키워드] animal model benefit clinical disease Clinical outcome clinical trial Clinical use COVID-19 Cytokines deficiency disease disease models dose drug Drug efficacy Drug screens effective Efficacy HCQ help High dose Hydroxychloroquine Intervention Lower respiratory tract malaria management Molecular biology Prophylaxis reduce respiratory Result rhesus rhesus macaque SARS-CoV-2 SARS-CoV-2 disease significantly therapeutic Therapeutics Treatment upper and lower respiratory tract use of hydroxychloroquine [DOI] 10.1172/jci.insight.143174 PMC 바로가기 [Article Type] Research Article
Clinical Trials [and Tribulations]: The Immediate Effects of COVID-19 on IBD Clinical Research Activity in the UK임상 시험 [및 고난]: 영국의 IBD 임상 연구 활동에 대한 COVID-19의 즉각적인 영향Article Published on 2020-12-022022-09-11 Journal: Journal of Crohn's & colitis [Category] 임상, [키워드] activity Analysis Care clinical clinical care clinical pathways Clinical research clinical trial clinical trials consequence country COVID-19 Effect effective effort focus Health Health care highlighting IBD Immediate Impact implication management offer pandemic Pathways Patient Perspective Reporting Research Research Ethics Safe SARS-CoV-2 therapeutic option therapy Trial [DOI] 10.1093/ecco-jcc/jjaa137 PMC 바로가기 [Article Type] Article
Bio-Inspired Systems in Nonsurgical Periodontal Therapy to Reduce Contaminated Aerosol during COVID-19: A Comprehensive and Bibliometric ReviewReview Published on 2020-12-022022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] adjuvant aerosol Aerosol generation article Bacteremia Bacterial benefit bio-inspired BOP caused changes in Clinical practice clinical trial Comprehensive contaminant Contaminated COVID-19 disease dental hygiene dentistry disease Effectiveness English global pandemic groups immunological parameters International nonsurgical periodontal therapy participant periodontal Periodontitis protocol public health emergency RCTs reducing reduction review risk statistical statistically significant System the SARS-CoV-2 virus therapy transmitted Treatment Validity virus [DOI] 10.3390/jcm9123914 PMC 바로가기 [Article Type] Review
Stopping Clinical Trials in Inflammatory Bowel Disease During the COVID-19 Pandemic Is Not a Responsible ActCOVID-19 전염병 동안 염증성 장 질환에 대한 임상 시험 중단은 책임있는 법이 아닙니다Article Published on 2020-12-022022-08-31 Journal: Journal of Crohn's & colitis [Category] MERS, 신약개발, 임상, [키워드] Act Care Chronic diseases clinical clinical trial Clusters COVID-19 COVID-19 patient Crohn disease Drug development Ethics framework Health Health care hospital in some Infection Inflammatory bowel disease medical procedures other diseases Patient pharmaceutical companies Pharmaceutical Company recruitment reduced registration trial Regulatory regulatory trials resource Stopping ulcerative colitis [DOI] 10.1093/ecco-jcc/jjaa127 PMC 바로가기 [Article Type] Article
Risk and mitigation actions for clinical trials during COVID-19 pandemic (RiMiCOPa)Research article Published on 2020-12-012022-10-05 Journal: Contemporary Clinical Trials Communications [Category] 임상, [키워드] affected clinical trial clinical trials consequence COVID-19 COVID-19 pandemic COVID-19 virus data management diffusion effective evaluate help Mitigation Mitigation actions pandemic patients professionals protocol recommendations risk mitigation [DOI] 10.1016/j.conctc.2020.100682 [Article Type] Research article
Chloroquine, hydroxychloroquine, and COVID-19: Systematic review and narrative synthesis of efficacy and safetyResearch article Published on 2020-12-012022-10-05 Journal: Saudi Pharmaceutical Journal : SPJ [Category] 신약개발, [키워드] adverse event Arrhythmias Chloroquine clearance clinical trial clinical trials clinician control group COVID-19 COVID-19 pandemic diagnosed drugs Efficacy Efficacy and safety Endpoint Evidence greater HCQ hospitalised COVID-19 patients human clinical trial Hydroxychloroquine identify incidence no significant difference observational study outcomes Probability Prophylaxis QTC prolongation required Safety Side-effects significant difference systematic review therapy treated patient Treatment unique Viral transmission [DOI] 10.1016/j.jsps.2020.11.003 [Article Type] Research article
Dose prediction for repurposing nitazoxanide in SARS‐CoV‐2 treatment or chemoprophylaxisSARS-CoV-2 치료 또는 화학 예방에서 nitazoxanide 용도 변경을 위한 용량 예측Original Article Published on 2020-12-012022-08-31 Journal: British Journal of Clinical Pharmacology [Category] MERS, 신약개발, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus clinical trial clinical trials Concentration coronavirus COVID‐19 dose doses expected food global pandemic healthy individual healthy individuals Human in vitro activity lung maintain multiple dose nitazoxanide optimal dose pharmacokinetic pharmacokinetic data pharmacokinetics plasma predict predicted prevention strategies QID receiving regimen reported respiratory Result SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 seamless severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown TID tizoxanide Treatment Trial was used [DOI] 10.1111/bcp.14619 PMC 바로가기 [Article Type] Original Article
Open questions for harnessing autophagy-modulating drugs in the SARS-CoV-2 war: hope or hype?SARS-CoV-2 전쟁에서 자가포식 조절 약물 활용에 대한 열린 질문: 희망 또는 과장?Article Published on 2020-12-012022-09-11 Journal: Autophagy [Category] MERS, SARS, 말라리아, 신약개발, 진단, 치료제, [키워드] Anti-inflammatory Anti-viral article autophagy benefit cellular Chloroquine clinical trial clinical trials concerning coronavirus COVID-19 COVID-19 outbreak despair drug drugs Efficacy emotional Hope Hydroxychloroquine immunology Infection Inflammation information Interaction lysophagy majority mechanism of action Microbiology molecular pandemic pathway Patient plaquenil pros question referred to SARS-CoV-2 Scientific community the SARS-CoV-2 therapeutic option Treatment virophagy virus viruses [DOI] 10.1080/15548627.2020.1779531 PMC 바로가기 [Article Type] Article