Neutrophils in secondary lymphoid organsArticle Published on 2021-08-302023-08-30 Journal: Immunology [Category] E형 간염, [키워드] Adaptive immunity Lymph node neutrophil [DOI] 10.1111/imm.13406 PMC 바로가기
Health care worker seromonitoring reveals complex relationships between common coronavirus antibodies and COVID-19 symptom duration의료 종사자 혈청 모니터링은 일반적인 코로나 바이러스 항체와 COVID-19 증상 기간 사이의 복잡한 관계를 보여줍니다Research Article Published on 2021-08-232022-09-10 Journal: JCI Insight [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Adaptive immunity antibody Antibody titer Antibody titers Betacoronavirus CCV Cellular immune response Cohort collected complex coronavirus COVID-19 COVID-19 severity COVID-19 symptom cross-reactive antibodies cross-reactive antibody duration of symptom elicited Health care Health care worker health care workers Hypothesis identify immune responses immunology individual Infection infections limit mechanism reduce reduced reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Serological assay serological assays significantly symptom duration [DOI] 10.1172/jci.insight.150449 PMC 바로가기 [Article Type] Research Article
Putative Role of Vitamin D for COVID-19 VaccinationCOVID-19 예방 접종을 위한 비타민 D의 추정 역할Review Published on 2021-08-202022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, 임상, [키워드] 2019 coronavirus disease ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Adaptive immunity airways Analysis angiotensin applied caused characterized Clinical use complementary complex component coronavirus coronavirus disease correlated COVID-19 COVID-19 vaccines Cytokines defend delayed response demonstrated develop DNA effective Effectiveness Efficacy effort elicited Evidence Extensive Factor global pandemic highly pathogenic IFN-III Immune cell infiltration immune dysfunction immune reactions immune signaling pathways Immunity inactivated incidence innate immune response Innate immunity innate response Interaction interferon interferons involved knowledge mechanism modulation molecular mechanism mRNA observational studies observational study pathophysiological progression Proinflammatory cytokine proinflammatory cytokines Protein subunit vaccines pulmonary disease RAS reduce Renin renin-angiotensin system respiratory role SARS-CoV-2 Serum level serum levels severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 patient severe COVID-19 patients severity severity of COVID-19 shown Significant Strategy subunit vaccines synthesis Treatment Vaccine vaccine efficacy Vaccines variant virus viruses Vitamin D Vitamin D supplementation [DOI] 10.3390/ijms22168988 PMC 바로가기 [Article Type] Review
Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria호중구는 P. falciparum 혈액 단계 메로조이트의 옵소닌 식세포작용에서 지배적이며 열성 말라리아로부터 보호합니다.Article Published on 2021-08-192024-08-08 Journal: Communications Biology [Category] 말라리아, [키워드] Adaptive immunity antibodies cellular immunity Infectious diseases malaria [DOI] 10.1038/s42003-021-02511-5 PMC 바로가기 [Article Type] Article
Delayed neutralizing antibody response in the acute phase correlates with severe progression of COVID-19급성기에서 지연된 중화 항체 반응은 COVID-19의 심각한 진행과 관련이 있습니다.Article Published on 2021-08-162022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immunity Admission analyzed antibodies chemiluminescence collected coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient Critical disease Delayed different time points disease disease severity Hospitalization moderate moderate disease NAb nAb response NAbs neutralization neutralization activity neutralization test Neutralizing activity neutralizing antibody Neutralizing antibody response on admission pathology Patient patients patients with moderate progression Pseudotyped virus reduction respiratory SARS-CoV-2 SARS-CoV-2 pseudotyped virus serum serum sample severe acute respiratory syndrome Coronavirus significantly higher symptom onset symptomatic viral infection were measured [DOI] 10.1038/s41598-021-96143-8 PMC 바로가기 [Article Type] Article
Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19시리아 햄스터의 시간적 omics 분석은 중간 정도의 COVID-19에 대한 세포 효과기 반응을 풉니다.Article Published on 2021-08-112022-09-10 Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] Adaptive immunity alterations Analysis Anti-viral blood sample Blood samples Cell cellular cellular mechanism cellular mechanisms Cellular responses COVID-19 COVID-19 patients COVID19 Cytotoxic T cell Cytotoxic T cells dataset datasets disease severity Endothelial cell endothelial cells epithelial cell epithelial cells Evidence expression functions Genes hamster identify IgM antibodies IgM antibody immune response immune responses Infection inflammatory lung injury Innate immunity longitudinal analysis lung Lung injury Lungs Macrophage macrophages Mechanisms of disease Moderate COVID-19 monocyte Monocyte-derived macrophages Pathomechanism Pathomechanisms post infection pro-inflammatory Pro-inflammatory genes proteomics response SARS-CoV-2 SARS-COV-2 infection scRNA-seq Subtypes T cell T cells Temporal Therapeutic strategies transcriptional response Viral viral clearance viral infection [DOI] 10.1038/s41467-021-25030-7 PMC 바로가기 [Article Type] Article
Weak immunogenicity of SARS-CoV-2 vaccine in patients with hematologic malignancies혈액 학적 악성 종양 환자에서 SARS-COV-2 백신의 약한 면역 원성Article Published on 2021-08-102022-09-01 Journal: Blood Cancer Journal [Category] MERS, SARS, 진단, [키워드] ACE-2 Adaptive immunity anti-S anti-S IgG Anti-spike B-cell binding BNT162b2 BNT162b2 vaccine CD19 cellular response correlated correlation COVID-19 Cutoff effective evaluated Haematological cancer healthy controls Hematologic malignancy Hematological malignancies humoral IFN-γ IgG immune protection immunogenicity male multivariable analysis of BNT162b2 Patient patients Predictive Probability Protective S protein SARS-CoV-2 vaccine significant increase significantly Spearman T-cell Response the patient the S protein translate Translational research Treatment vaccination Vaccine [DOI] 10.1038/s41408-021-00534-z PMC 바로가기 [Article Type] Article
Autoantibodies stabilize neutrophil extracellular traps in COVID-19자가 항체는 COVID-19에서 호중구 세포외 트랩을 안정화합니다Research Article Published on 2021-08-092022-09-10 Journal: JCI Insight [Category] MERS, SARS, 진단, 치료제, [키워드] Adaptive immunity antibodies antibody associations autoantibodies autoantibody Autoimmunity circulating clearance contribute correlation COVID-19 COVID-19 sera D-dimer Degradation degrade demonstrated determine Efficiency fraction function functional greater healthy control healthy controls Hospitalized IgG IgG and IgM IgM immunopathology impair individual inherent inverse correlation Level mechanical ventilation NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils oxygen oxygen supplementation Oxygenation Patient patients purified required sera serum severe COVID-19 Thromboinflammation variety with COVID-19 [DOI] 10.1172/jci.insight.150111 PMC 바로가기 [Article Type] Research Article
Duration of post–COVID-19 symptoms is associated with sustained SARS-CoV-2–specific immune responses코로나19 이후 증상의 지속 기간은 지속적인 SARS-CoV-2 특정 면역 반응과 관련이 있습니다.Research Article Published on 2021-08-092022-09-12 Journal: JCI Insight [Category] MERS, SARS, 진단, [키워드] Adaptive immunity antibody Antigen CD4 cell population circulating correlation COVID-19 COVID-19 patient COVID-19 symptom COVID-19 symptoms demonstrated Duration etiology evaluated expected follicular groups helper cell IgG immune cell types immune response immune responses immune signature immunology individual investigated magnitude marker median PASC Patient Peripheral blood persistence phenotypic resolved SARS-COV-2 infection SARS-CoV-2 spike protein Significant Spike protein subset sustained Symptom symptom duration symptom resolution systemic inflammation T cell T cell response T cells Viral antigen viral antigens [DOI] 10.1172/jci.insight.151544 PMC 바로가기 [Article Type] Research Article
GIANA allows computationally-efficient TCR clustering and multi-disease repertoire classification by isometric transformationArticle Published on 2021-08-042022-10-04 Journal: Nature Communications [Category] MERS, SARS, 바이오마커, [키워드] Accuracy Adaptive immunity Antigen Autoimmune disease Autoimmune diseases Cancer Cluster Clustering Cohort dataset diagnostic Genome informatics grouping immune immunological inefficient isometric transformation Non-invasive Patient platform provide receptors sequence sequence similarity similarity specificity T-cell receptor TCR TCR sequences TCRs therapeutic targets [DOI] 10.1038/s41467-021-25006-7 PMC 바로가기 [Article Type] Article