Development of a recombinant Newcastle disease virus-vectored vaccine for infectious bronchitis virus variant strains circulating in EgyptResearch Article Published on 2019-02-112022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] analyses avirulent bronchitis cause chick circulating circumvent clinical disease Clinical sign comparable Complete develop development disease Express expressing growth IBV immunofluorescence in vitro Infectious Bronchitis Virus Lineage live-attenuated vaccine Middle East mutate newcastle disease virus parental prevalent provided recombine reduced reduction in resulting S glycoprotein S protein S protein expression significantly Single-dose SPF strain supplementary material tracheal vaccination Vaccine vaccine candidate variant viral shedding virulent virus viruses were expressed white wild type [DOI] 10.1186/s13567-019-0631-5 PMC 바로가기 [Article Type] Research Article
Bats and CoronavirusesReview Published on 2019-01-092022-10-28 Journal: Viruses [Category] Coronavirus, MERS, SARS, [키워드] acute diarrhea acute respiratory syndrome bat bats Clinical sign coronavirus Coronaviruses CoV CoVs Critical disease epidemic diarrhea Factor Host Human identify immune response in vitro in vivo include knowledge limitations mammals MERS Middle East observation outbreak overcome researcher reservoir resource severe disease strain syndrome unique virus [DOI] 10.3390/v11010041 PMC 바로가기 [Article Type] Review
SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats ( Rousettus aegyptiacus )Article Published on 2018-12-192022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] ACE2 acute respiratory syndrome animal model bat bats Clinical sign coronavirus CoV Emerging infectious diseases enzyme experiment fruit increase in infect Infection oropharyngeal swab positive post inoculation receptor respiratory tissues robust Rousettus specific antibody Viral RNA WIV1-CoV [DOI] 10.3390/v10120727 PMC 바로가기 [Article Type] Article
Recombinant Infectious Bronchitis Viruses Expressing Chimeric Spike Glycoproteins Induce Partial Protective Immunity against Homologous Challenge despite Limited Replication In VivoVaccines and Antiviral Agents Published on 2018-09-122022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] avian infectious bronchitis virus BeauR bronchitis cause cellular challenge Characteristics characterized chimeric ciliary Clinical sign Clinical signs conducted conformational contagious coronavirus cross-protection determine expressing glycoprotein Heterologous homologous IBV IMPROVE in vitro in vivo induce Limited Live attenuated vaccines M41 mucosal tissue Partial partial protection PROTECT protective immunity recombinant recombinant vaccine reduction in reductions in replicated Replication Respiratory disease responsible rIBV S1 S1 and S2 S2 subunit serotype serum serum antibody single vaccination spike strain surface protein the S1 subunit tracheal Trial vaccination Vaccine Viral load viral RNA load virulent virus [DOI] 10.1128/JVI.01473-18 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents
Experimental infection of pigs with H1 and H3 influenza A viruses of swine by using intranasal nebulizationResearch Article Published on 2018-03-272023-05-24 Journal: BMC veterinary research [Category] Fulltext, 신종인플루엔자, [키워드] Clinical sign experimental Infection Influenza inoculation nebulization pig viral shedding [DOI] 10.1186/s12917-018-1434-z PMC 바로가기 [Article Type] Research Article
Efficacy of genogroup 1 based porcine epidemic diarrhea live vaccine against genogroup 2 field strain in JapanResearch Published on 2018-02-022022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] Administered Antibody titer caused Clinical sign conditions control group diarrhea Efficacy epidemic diarrhea evaluated exhibited immune response Immunity Infectious disease Japan lactogenic Lactogenic immunity mortality rate negative control Newborn PEDV Porcine epidemic diarrhea Porcine epidemic diarrhea virus pregnant prevalent reduced Result serum significantly supplementary material survival rate Symptom the vaccine vaccination Vaccine virus Virus neutralization watery [DOI] 10.1186/s12985-018-0940-8 PMC 바로가기 [Article Type] Research
Evidence of porcine epidemic diarrhea virus (PEDV) shedding in semen from infected specific pathogen-free boarsResearch Article Published on 2018-01-242022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] cause circulating Clinical sign determine diarrhea disease spread epidemic diarrhea Evidence evidence of fraction Genome genomic highly pathogenic inoculated investigated Mortality North America occur PEDV question raise RT-qPCR Semen specific pathogen-free SPF Spread strain the United State Transient Transmission transmitted viral shedding virus watery [DOI] 10.1186/s13567-018-0505-2 PMC 바로가기 [Article Type] Research Article
Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, ChinaOriginal Article Published on 2017-12-062022-10-31 Journal: European Journal of Clinical Microbiology & Infect [Category] Coronavirus, MERS, [키워드] 229E age children China Clinical characteristics clinical feature clinical manifestation Clinical sign collected coronavirus coughing Epidemiology Evidence Fever group Guangzhou, China highest HKU1 Hospitalized Human human coronavirus Infection less NL63 OC43 Patient PCR Pediatric patient Pneumonia polymerase chain positive Prevalence provide rale respiratory diseases Respiratory pathogens respiratory tract infection respiratory virus Retrospective study significant difference strain subtropical Symptoms tested throat swab [DOI] 10.1007/s10096-017-3144-z PMC 바로가기 [Article Type] Original Article
Virulence of current German PEDV strains in suckling pigs and investigation of protective effects of maternally derived antibodiesArticle Published on 2017-09-072022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] age antibody assigned caused Cell Clinical sign clinically conditions epidemic diarrhea Europe European group healthy help induce inoculated MDA morbidity naïve Occurrence offspring outbreak Outbreaks PEDV pregnant Prevent protective effect Randomly reported specific antibody strain subset the United State Trial vaccination virulence virus were assessed [DOI] 10.1038/s41598-017-11160-w PMC 바로가기 [Article Type] Article
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronavirusesArticle Published on 2017-07-282022-11-01 Journal: Science Translational Medicine [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] administration Antiviral antiviral therapy bat-CoV bat-CoVs Cell culture circulating clinical development Clinical sign CoV CoV infection CoVs disease Ebola virus disease effective Endemic Epidemic epithelial Evidence functions globe GS-5734 heterogeneous Host hosts Human human CoV human lung cells human population immunologically in vitro infections inhibit inhibiting lung viral load medical need MERS-CoV Middle East naïve nucleotide prodrug Pathogenesis primary human airway Prophylactic reduced Replication Respiratory disease SARS-CoV severe disease significantly Spread therapeutic therapy Treatment Vaccines viral infection zoonotic Zoonotic coronavirus [DOI] 10.1126/scitranslmed.aal3653 PMC 바로가기 [Article Type] Article