Effects of surgical and FFP2/N95 face masks on cardiopulmonary exercise capacity수술 및 FFP2/N95 안면 마스크가 심폐 운동 능력에 미치는 영향Randomized Controlled Trial Published on 2020-07-062022-08-13 Journal: Clinical Research in Cardiology [Category] MERS, SARS, 임상, [키워드] age Blood BMI Cardiac output Cardiopulmonary Comfort cross-over discomfort domain Effect Exercise capacity expiratory Expiratory flow Face mask Face masks FFP2/N95 forced expiratory volume healthy healthy individuals in healthy individuals individual Lactate male Mask Masks pandemic participant peak peak expiratory flow performed physical Physical exercise pulmonary function parameter pulmonary function parameters questionnaire Randomized recommendation reduced reported response Result SARS-CoV2 significantly significantly lower surgical Surgical masks These data Ventilation was reduced wearing face mask were assessed [DOI] 10.1007/s00392-020-01704-y PMC 바로가기 [Article Type] Randomized Controlled Trial
Innate immunity in COVID-19 patients mediated by NKG2A receptors, and potential treatment using Monalizumab, Cholroquine, and antiviral agentsResearch article Published on 2020-07-012022-10-05 Journal: Medical Hypotheses [Category] 치료제, [키워드] antibody antiviral agent Antiviral agents blocking Blood Cancer cancers CD8 CD8+ CD8+ cell Cell Chloroquine clinical trials COVID-19 COVID-19 infected patient COVID-19 patient CTLs cytokine secretion cytotoxic cytotoxicity disease Disease progression effective functional generate healthy controls healthy individuals Host immune response Immunity individual inhibiting inhibitory Innate innate immune response Innate immunity interferon lymphocyte mechanism mild infection modulated Monalizumab natural neutrophil NK cell NK cell function NK cells NKG2A Novel coronavirus outbreak over-expressing overexpression Patient Phase 2 Potential treatment receptor receptors reduced required resulting SARS SARS-CoV-2 severe COVID-19 Severe infection Side effect significantly significantly lower T-cell treated tumor growth tumor progression viral pathogen viruses weakened immune system [DOI] 10.1016/j.mehy.2020.109777 [Article Type] Research article
The effects of blood group types on the risk of COVID-19 infection and its clinical outcome혈액형이 COVID-19 감염 위험과 임상 결과에 미치는 영향Article Published on 2020-06-232022-09-10 Journal: Turkish Journal of Medical Sciences [Category] SARS, 치료기술, [키워드] Acute respiratory failure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 advanced age analyzed Bank Blood Blood Bank Blood Group Blood groups caused chronic disease Chronic diseases Clinical outcome clinical outcomes Clinical studies clinical study Comorbidities Control control group controls coronavirus coronavirus disease Coronavirus-2 COVID-19 COVID-19 infection COVID-19 patients diagnosis of COVID-19 disease disease outbreak Effect followed by Frequency groups healthy individuals infected with COVID-19 Infection Infectious disease infectious disease outbreak intensive care intensive care unit intubation material mortalities Mortality not affect outcome pandemic Patient PCR Protective respiratory Respiratory failure Result risk risk of COVID-19 risk of infection SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Sex shown significantly lower significantly more Spread statistically susceptibility the patient the SARS-CoV-2 university [DOI] 10.3906/sag-2005-395 PMC 바로가기 [Article Type] Article
Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injurySpecial Section: SARS-CoV-2 Published on 2020-06-092022-10-30 Journal: National Science Review [Category] COVID-19, [키워드] 2019 novel coronavirus 2019-nCoV 2019-nCoV infection 2019-nCoV infections blood plasma caused changes in Characteristics characterized China clinical feature combating COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine response Cytokine storm Cytokines disease severity elevated emerging disease function G-CSF healthy individuals HGF IFN-α2 IFN-γ IL-10 IL-12 IL-17 IL-1α IL-2 IL-4 IL-7 IMPROVE IP-10 Lung injury M-CSF mechanism MONITOR outbreak pathogenesis of COVID-19 Patient plasma Pneumonia Potential biomarker predict reported SARS-CoV-2 selective severity Shenzhen significantly the disease therapeutic treat Viral load Wuhan, China [DOI] 10.1093/nsr/nwaa037 PMC 바로가기 [Article Type] Special Section: SARS-CoV-2
Molecular Insights Into SARS COV-2 Interaction With Cardiovascular Disease: Role of RAAS and MAPK SignalingPharmacology Published on 2020-06-032022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activated acute respiratory distress acute respiratory syndrome benefit cardiovascular cardiovascular burden cardiovascular disease cardiovascular risk caused China contagious coronavirus CoV COVID-19 COVID-19 patients CVD de novo demonstrated drug globe healthy individuals higher risk indicated induce Infectious disease insight MAPK MAPK signaling molecular morbidity new virus Novel coronavirus observation offer outbreak outcome pandemic Pathogenesis pathway Patient predisposition progression RAAS respiratory manifestation role SARS-CoV SARS-CoV infection SARS-CoV-2 SARS-COV-2 infection sequence similarity severe COVID-19 signaling pathways Spread syndrome utility Vascular damage Viral pneumonia Wuhan [DOI] 10.3389/fphar.2020.00836 PMC 바로가기 [Article Type] Pharmacology
Genome-wide DNA methylation and gene expression patterns reflect genetic ancestry and environmental differences across the Indonesian archipelago게놈 차원의 DNA 메틸화 및 유전자 발현 패턴은 인도네시아 군도 전체의 유전적 조상과 환경적 차이를 반영합니다.Research Article Published on 2020-05-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] admixture Analysis capture complex country CpG dataset differential expression differentially expressed disease Diversity DNA methylation driven by environmental factor European examined excluded expression expression level expression levels Gene Expression gene expression pattern Genetic genomic healthy individuals highlighting Host human populations humans identify immune function Immunity implication in healthy individuals individual Indonesia Infectious disease introgression involved island majority Methylation molecular Molecular medicine molecular pattern molecular phenotype Neanderthal New pathway Pathways Phenotypes Population promoter robust selective pressure Sequencing Sumba tested Transcription tropical understanding Variation [DOI] 10.1371/journal.pgen.1008749 PMC 바로가기 [Article Type] Research Article
DNA Methylation Changes Separate Allergic Patients from Healthy Controls and May Reflect Altered CD4 + T-Cell Population StructureDNA 메틸화는 건강한 대조군과 알레르기 환자를 분리하고 변경된 CD4 + T-세포 집단 구조를 반영할 수 있습니다.Research Article Published on 2014-01-022022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allergen allergic allergic rhinitis allergy alteration Altered approach assumed Author blood cell CD4 cells change changes in compared Control controls different disease DNA DNA methylation Epigenetic epigenomics etiology Evidence explain found Gene Expression gene expression profile Gene expression profiles healthy control healthy controls healthy individual healthy individuals heterogeneity highlight humans Illumina immune in vitro model individuals infectious agent infectious agents Inflammatory diseases life mechanism memory Methylation Microarrays molecular Patient PBMC PBMCs phenotype Population profile proportion proportions psoriasis purified SAR seasonal Seasonal allergic rhinitis Separate separation Stratification Structure subtype Support T cells T-cell T-cells White blood cell [DOI] 10.1371/journal.pgen.1004059 PMC 바로가기 [Article Type] Research Article
Genic Intolerance to Functional Variation and the Interpretation of Personal Genomes기능적 변이에 대한 유전적 편협성과 개인 게놈의 해석Research Article Published on 2013-08-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Author caused Characteristics defined develop developmental disorder developmental disorders different disease disease causing disorder disorder classe disorder classes effort ESP example excess Exome Exome Sequencing Project expected facilitate found functional functional genetic variation functional variant functional variation Gene genetic disease Genetic variation Genome genome-wide scoring healthy individuals human disease human disease network human gene human genes human population Immunological disorders in healthy individual intolerance intolerance score intolerance scoring less Mendelian disease Mendelian diseases Mutation mutations Neutral NHLBI nucleotide occur opposite pathogenic mutations quantitative assessment responsible sequence significantly more Single nucleotide variant standing genetic variation utility variants Variation [DOI] 10.1371/journal.pgen.1003709 PMC 바로가기 [Article Type] Research Article
Gene Set Signature of Reversal Reaction Type I in Leprosy Patients나병 환자의 역전 반응 유형 I의 유전자 세트 서명Research Article Published on 2013-07-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 한센병, [키워드] a major accurate Affect affected Analysis Anti-inflammation anti-inflammatory mediator anti-inflammatory mediators Antigen antigens arachidonic acid Author Blood conducted Critical cured defined Definition diagnosed Diagnosis different differential expression differentially regulated genes Endemic enrolled environmental factor environmental factors evaluated Factor functional Gene genes encoding Genetic genetic background genetic profile Genome healthy individual healthy individuals immune incidence increased risk Inflammatory response Innate immunity leprosy majority mediators metabolism Mycobacterium leprae nerve damage Pathogenesis Patient performed Predictive pro-inflammatory Prospective Study reaction reflect Regulation replicated retrospective Retrospective study reversal reversal reactions RNA sample RNA samples signature Stimulation subsequent subset Transcriptome Trigger triggers Type validation Validity Whole blood [DOI] 10.1371/journal.pgen.1003624 PMC 바로가기 [Article Type] Research Article