Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2
SARS-CoV-2 진입의 Hydroxychloroquine 매개 억제는 TMPRSS2에 의해 약화됩니다
Research Article
[키워드] ablated
activate
activated
activating
antiviral activities
antiviral activity
Autoimmune disorders
block
cathepsin L
Cathepsins
cause
Cell
cell entry
cell surface
cell-culture studies
cell-culture systems
Chloroquine
cleave
clinically
Combination
combinations
coronavirus
COVID-19
COVID-19 patient
dependent on
Efficacy
endocytosis
Endosomal acidification
endosomal protease
explain
functional
furin
furin cleavage site
furin-cleavage site
global public health
human clinical trial
human clinical trials
Hydroxychloroquine
identify
in vivo
Infection
inhibit
inhibit SARS-CoV-2
interfere
introduced
lack
malaria
membrane fusion
observé
pathogenic coronavirus
pathway
plasma
plasma membrane
Prevent
protease TMPRSS2
Protein
Proteins
proteolytic activity
Receptor binding
reversed
S protein
S proteins
SARS Coronavirus
SARS-CoV-1
SARS-CoV-1 and -2
SARS-CoV-2
SARS-CoV-2 entry
SARS-COV-2 infection
SARS-CoV-2 S protein
SARS-CoV-2 spike
shown
target cell
target cells
tested
the cell
the SARS-CoV-2
these compounds
TMPRSS2
TMPRSS2 expression
TMPRSS2 inhibitor
TMPRSS2 pathway
treat
treated
treatment for COVID-19
utility
Viral
viral entry
viral infection
[DOI] 10.1371/journal.ppat.1009212 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1009212 PMC 바로가기 [Article Type] Research Article