Construct validity of the Post-COVID-19 Functional Status Scale in adult subjects with COVID-19Research Published on 2021-02-032022-10-31 Journal: Health and Quality of Life Outcomes [Category] COVID-19, MERS, [키워드] activities activity adult subject Analysis association construct validity Course COVID-19 demonstrated diary domain EQ-5D evaluated Facebook functional Functional status group impairment increase in Infection intensity limitation limitations onset of symptoms productivity Quality of life questionnaire raising recovering from COVID-19 reduction Result SARS-CoV-2 scale statistical subject Symptom Symptoms the disease Validity with COVID-19 women work [DOI] 10.1186/s12955-021-01691-2 PMC 바로가기 [Article Type] Research
A Comprehensive Summary of the Knowledge on COVID-19 TreatmentReview Published on 2021-02-012022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] accelerated Chinese Chinese medicine Clinical outcome complementary Comprehensive coronavirus coronavirus disease country COVID-19 COVID-19 epidemic disease drug drug candidate effective Efficacy epidemiologist IMPROVE Intervention knowledge limitations medication pandemic patients with COVID-19 potential mechanisms Potential treatment researcher Strategies TCM Treatment treatment strategy Trial [DOI] 10.14336/AD.2020.1124 PMC 바로가기 [Article Type] Review
Identification of potential Mpro inhibitors for the treatment of COVID-19 by using systematic virtual screening approach체계적인 가상 스크리닝 접근법을 통한 COVID-19 치료를 위한 잠재적인 Mpro 억제제 식별Article Published on 2021-02-012022-09-11 Journal: Molecular diversity [Category] SARS, 신약개발, 치료기술, 치료제, [키워드] acute respiratory syndrome amides antiviral agent Antiviral agents approach approved Asinex BioDesign carried caused China clinically Compound conformational Corona virus coronavirus COVID-19 creating derivatives diagnostic drug drug library exhibiting FDA genomic RNA globe identification inhibitor inhibitors Interaction iodixanol iotrolan lead limitations Modification MPro nelfinavir non-structural protein non-structural proteins Novel coronavirus pathogen pharmacophore polyprotein polyproteins pralmorelin Precision predicted produced protease pyrazoles PYRROLIDINE respiratory Respiratory complications Ritonavir saquinavir SARS-CoV-2 Screening screenings Severe acute respiratory syndrome Spread target protein therapeutic agent therapeutic agents translation Treatment Virtual screening virus Virus Disease worldwide pandemic [DOI] 10.1007/s11030-020-10130-1 PMC 바로가기 [Article Type] Article
Co-infection in patients with hypoxemic pneumonia due to COVID-19 in Reunion IslandObservational Study Published on 2021-01-292022-10-04 Journal: Medicine [Category] 임상, [키워드] 229E absence Co-infection Cohort collected commenced conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case Culture D-dimer D-dimer level database elevated evaluate expected France H1N1 Haemophilus influenzae hospital human coronavirus hypoxemic incidence Influenza Influenza virus island limitations multiplex Multiplex PCR pathogen Patient PCR Pneumonia polymerase chain required SARS-CoV-2 screened Spain specific treatment sputum culture Staphylococcus aureus Streptococcus pneumoniae Treatment university [DOI] 10.1097/MD.0000000000024524 PMC 바로가기 [Article Type] Observational Study
VERSO: A comprehensive framework for the inference of robust phylogenies and the quantification of intra-host genomic diversity of viral samplesArticle Published on 2021-01-282022-10-28 Journal: Patterns [Category] COVID-19, [키워드] Abstract acute respiratory syndrome Analysis approach Cluster co-occurrence condition consensus sequences Contact tracing coronavirus COVID-19 COVID-19 pandemic data-driven dataset diffusion epidemiological Evolution Evolution of SARS-CoV-2 explain Frequency genomic Genomic surveillance highlight homoplasies homoplastic variants identify IMPROVE Infection infection chain Intra-host diversity intra-host genomic diversity involved joint limitation limitations mutations outperform pathogen phylogenetic inference Phylogenomics Phylogeny platform Positive selection predict profiles quantification raw sequencing data Research reveal RNA sequencing robust SARS-CoV-2 SARS-CoV-2 consensus sequence SARS-CoV-2 evolution selected sequencing data spike gene Surveillance variant viral evolution viral genomes viral sample Viral variants [DOI] 10.1016/j.patter.2021.100212 PMC 바로가기 [Article Type] Article
Short-term outpatient follow-up of COVID-19 patients: A multidisciplinary approachResearch Paper Published on 2021-01-282022-10-31 Journal: EClinicalMedicine [Category] COVID-19, [키워드] addition Anxiety approach Cardiopulmonary Cardiopulmonary function Care caused COVID-19 COVID-19 patient COVID-19 patients Depression diffusion capacity discharge ECG evaluated expiratory finding Follow-up functional heart Hospitalization ICU ICU patient impairment investigated left limitations Long-term follow-up mapped mean difference mechanical ventilation Multidisciplinary follow-up myocardial damage New York non-ICU patients Out-patient clinic outpatient clinic Patient patients Psychological psychological adjustment Psychological distress PTSD pulmonary dysfunction pulmonary fibrosis Pulmonary function testing questionnaire recommendation reported reveal suffered ventricular Volume was measured [DOI] 10.1016/j.eclinm.2021.100731 PMC 바로가기 [Article Type] Research Paper
Review of Medical Therapies for the Management of Pulmonary EmbolismReview Published on 2021-01-262022-10-30 Journal: Medicina [Category] Coronavirus, [키워드] administration antagonist antagonists Anticoagulant Anticoagulant treatment Anticoagulants anticoagulation clearance COVID-19 direct oral anticoagulants (DOAC) effective Embolism employment Evidence Evolution heparin Interaction limitations liver malignancy management medication parameters Patient pharmacological management populations provided pulmonary pulmonary embolism (PE) renal Research review Safe therapeutic option therapy Toxicity venous thromboembolism (VTE) [DOI] 10.3390/medicina57020110 PMC 바로가기 [Article Type] Review
T cell response to SARS-CoV-2 infection in humans: A systematic reviewResearch Article Published on 2021-01-252022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] Adults antibody article Asymptomatic carried complex Consensus COVID-19 COVID-19 case Critical Critical disease cross-reactive demonstrated develop disease disease severity epidemiological Epitopes evaluate feasible finding heterogeneity hospitalised patient Immunity individuals Inference involved lack limitations majority methodological limitation paper pauci-symptomatic peer-reviewed population level preserved recipients Research researcher researchers responses Result RNA robust SARS-CoV-2 SARS-COV-2 infection screened Surveillance susceptibility synthesised systematic review T cell lymphopenia T cell memory T cell response understanding uninfected unlikely Vaccine Vaccine development virus-specific T cell [DOI] 10.1371/journal.pone.0245532 PMC 바로가기 [Article Type] Research Article
Development of a Cell-Based Luciferase Complementation Assay for Identification of SARS-CoV-2 3CL pro InhibitorsArticle Published on 2021-01-242022-10-28 Journal: Viruses [Category] COVID-19, [키워드] 3CL pro 3CLpro Antiviral antiviral drug BSL-2 BSL-3 facility Cell cleavage cleavage site Complementation compounds COVID-19 current cytotoxicity development effort exhibited facilitate False positive FIVE HCV HIV identification identify in vitro inhibit SARS-CoV-2 inhibitor inhibitors of SARS-CoV-2 lack lentiviral limitations luciferase luciferase activity other compound performed protease protease inhibitors Proteases reduce replication-competent virus reported reporter SARS-CoV-2 screened small molecule specificity viral replication Z-FA-FMK [DOI] 10.3390/v13020173 PMC 바로가기 [Article Type] Article
‘It’s been adapted rather than impacted’: A qualitative evaluation of the impact of Covid‐19 restrictions on the positive behavioural support of people with an intellectual disability and/or autismOriginal Article Published on 2021-01-222022-10-29 Journal: Journal of Applied Research in Intellectual Disabilities [Category] Coronavirus, MERS, SARS, [키워드] analysed applied approach behavioural behaviours that challenge benefit Care conducted COVID‐19 distress help intellectual disability limitations overcome PBS positive positive behavioural support Qualitative Quality of life Result Stress Support supported thematic analysis [DOI] 10.1111/jar.12859 PMC 바로가기 [Article Type] Original Article