mononuclear cell – Page 19 – Communicable Diseases Research

COVID-19 patient transcriptomic and genomic profiling reveals comorbidity interactions with psychiatric disorders

COVID-19 환자 전사체 및 게놈 프로파일링은 정신 장애와의 동반 질환 상호 작용을 나타냅니다

Article

Published on 2021-03-152022-09-10
Journal: Translational Psychiatry [Category] SARS, 바이오마커, 유전자 메커니즘,

Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications

Article

Published on 2021-03-122022-10-04
Journal: Nature Communications [Category] SARS, 바이오마커, 치료기술, 치료법,

[키워드] Affect alteration arginine association change chemokine Correlation analysis COVID-19 COVID-19 patient COVID-19 patients CRS cytokine cytokine release Cytokines Diseases Ex vivo healthy controls Host hyperinflammation IL-1α IL-1β IL-6 immune response implication Inflammatory response Injury M-CSF metabolic pathway metabolism metabolite metabolite analysis metabolomic metabolomics Mild modulate mononuclear cell outcome Peripheral blood Prognostic markers proinflammatory Proinflammatory cytokine purine Regulatory reveal rhesus macaque SARS-CoV-2 SARS-COV-2 infection serum sample severe COVID-19 patients stratified syndrome therapeutic therapeutic target
[DOI] 10.1038/s41467-021-21907-9 PMC 바로가기 [Article Type] Article

Emergency Lung Transplantation after COVID-19: Immunopathological Insights on Two Affected Patients

COVID-19 이후 긴급 폐 이식: 영향을 받은 두 환자에 대한 면역병리학적 통찰력

Case Reports

Published on 2021-03-102022-09-12
Journal: Cells [Category] 진단,

[키워드] activating ARDS Bronchoalveolar lavage fluid chemokines chemotactic collected components condition COVID-19 COVID-19 patient Culture cytokine Cytokine analysis Diffuse alveolar damage disease Emergency expression profiling extensive lung damage Factor feature histopathological Humoral immunity iatrogenic IL-6 immune activation immune profiling immunology immunopathological Immunosuppression Inflammasome insight interstitial pneumonia Italian lung lung transplantation Lungs mimicking molecular mononuclear cell overexpression pathogen pathological PBMCs Peripheral blood proinflammatory proliferative receptor receptors SARS-CoV-2 SARS-CoV-2-stimulated PBMC specimen supernatants Support sustained tissue damage TNF-α usual interstitial pneumonia was performed were measured
[DOI] 10.3390/cells10030611 PMC 바로가기 [Article Type] Case Reports

Bioinformatic analyses hinted at augmented T helper 17 cell differentiation and cytokine response as the central mechanism of COVID‐19–associated Guillain‐Barré syndrome

생물정보학 분석은 COVID-19 관련 길랑-바레 증후군의 중심 기전으로서 증강된 T 헬퍼 17 세포 분화 및 사이토카인 반응을 암시

Original Article

Published on 2021-03-102022-09-10
Journal: Cell Proliferation [Category] SARS, 유전자 메커니즘,

[키워드] Abnormalities Activation Algorithm Analysis analyzed association autoimmune attack autonomic Bioinformatic CD86 cell differentiation Cluster Clustering conditions COVID‐19 COVID‐19 CSF2 cytokine cytokine response databases demonstrated disease disease entity DisGeNET Evidence Genes Genetic Guillain‐Barré syndrome IL10 IL1B IL23A IL27 IL2RA IL4 IL6 Interaction ISG20 ITGAM knowledge Macrophage Markov material mechanism mononuclear cell mononuclear cells network analysis objective parameter pathophysiological mechanism pathway Patient PBMC performed Peripheral blood Peripheral blood mononuclear cells peripheral nerves platform PTGS2 Regulatory regulatory genes required Result retrieved risk SARS‐CoV‐2 shown STRING subset suggested syndrome T helper Th17 TNF Transcriptome transcriptome analysis Version was used
[DOI] 10.1111/cpr.13024 PMC 바로가기 [Article Type] Original Article

Dynamic blood single-cell immune responses in patients with COVID-19

Article

Published on 2021-03-062022-10-04
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 변종,

[키워드] 2019 coronavirus disease activated addition Analysis B cell B cell receptor BCR Blood caused CD14+ monocytes CD4+ T lymphocyte CD8+ T lymphocytes Cell Biology change Cohort Concentration condition Control controls COVID-19 critical condition DCs dendritic cell dynamic Ferroptosis Gene Expression health emergency IFI27 IFN-I IFN-I pathway IFN-α immune response indicated Infectious diseases Interferon-α investigated MAPK mononuclear cell mRNA mRNA level naïve natural killer cell outbreak Pathogenesis pathway Patient patients with COVID-19 PBMCs Peripheral blood progenitor cell Protein reduction reveal SARS-CoV-2 antigens SARS-COV-2 infection scRNA-seq sequence Sequencing serum significant decrease significantly significantly increased single-cell Stage T cell T cell receptor TCR the disease the SARS-CoV-2 virus therapeutic potential Transcriptome treating COVID-19 type I interferon validation cohort
[DOI] 10.1038/s41392-021-00526-2 PMC 바로가기 [Article Type] Article

Impact of SARS-CoV-2 infection on the recovery of peripheral blood mononuclear cells by density gradient

밀도 구배에 의한 말초 혈액 단핵 세포의 회복에 대한 SARS-CoV-2 감염의 영향

Article

Published on 2021-03-012022-09-01
Journal: Scientific Reports [Category] SARS, 진단,

[키워드] alteration Biological techniques Blood blood donor Cell centrifugation changes in circulating Complication coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients density gradient density gradient centrifugation disease severity Donor early phase early stage exhibited explain forms fraction healthy control Hyperinflammatory Hyperinflammatory response immature Immune-mediated Impact IQR lymphocyte Lymphocytes median Medical research medium Monocytes mononuclear cell mononuclear cells neutrophil Neutrophils Patient PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells Predictive reduced respiratory responsible Result SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 virus infection sedimentation severity shift Spread subset t -test the cell the cells the disease virus infection while Whole blood
[DOI] 10.1038/s41598-021-83950-2 PMC 바로가기 [Article Type] Article

Epigenetic Landscapes of Single-Cell Chromatin Accessibility and Transcriptomic Immune Profiles of T Cells in COVID-19 Patients

Immunology

Published on 2021-02-242022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS,

[키워드] Accessibility accompanied Activation Analysis approaches CD4 CD69 CD8 Cell Characteristics chromatin chromatin accessibility Control coronavirus diseases COVID-19 creating Critical element enhancer Epigenetic expressed function Genes HCs healthy HLA class II HLA-DRA HLA-DRB1 HLA-DRB5 immune Immune profile infected with COVID-19 inflammatory genes inflammatory pathways inflammatory state involved key factor landscape less MAPK moderate mononuclear cell motif Necrosis NFKBIA nine Pathogenesis Patient patients with COVID-19 PBMCs performed Peripheral blood PIK3R1 profile profiles promoter proportion Protein provided regions RNA S100A9 SARS-CoV-2 scATAC-seq scRNA-seq ScRNA-seq analysis seq Sequencing signaling pathway significantly Single Cell single-cell T cell T cells T-cell TBX21 Th1 TNF transcriptome profiling transcriptomic upregulated were used
[DOI] 10.3389/fimmu.2021.625881 PMC 바로가기 [Article Type] Immunology

SARS-CoV-2 early infection signature identified potential key infection mechanisms and drug targets

SARS-CoV-2 조기 감염 시그니처는 잠재적인 주요 감염 메커니즘 및 약물 표적 식별

Research Article

Published on 2021-02-182022-09-10
Journal: BMC Genomics [Category] MERS, 신약개발, 유전자 메커니즘,

[키워드] addition antidepressants association atorvastatin BALF BALF cells bimodal biopsies Bronchoalveolar lavage fluid Bronchoalveolar lavage fluid cells candidate Candidates caused Cell characterized COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 outbreak COVID-19 treatments cultured cell cultured cells database dataset deaths Differential gene expression disease drug drug target early infection effective Efficacy expression profile Gene Expression gene signature HDAC healthy healthy and infected patients highlighting ibuprofen identify IFIT2 Immune cell immune cells infected patient infected with SARS-CoV-2 Infection infection mechanism inhibitors investigated ketoconazole lung lung biopsies mechanism moderate mononuclear cell mononuclear cells Mortality NFKBIA PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells PPP1R15A Previous studies previous study public health Result robust safety profile SARS-CoV-2 SARS-CoV-2 gene expression signature SARS-COV-2 infection Sequencing severely infected patient severely infected patients severity shown signature single-cell supplementary material the disease the SARS-CoV-2 therapy TNFAIP3 transcriptional activity treating SARS-CoV-2 infection Treatment Vaccine
[DOI] 10.1186/s12864-021-07433-4 PMC 바로가기 [Article Type] Research Article

Inflammation and Antiviral Immune Response Associated With Severe Progression of COVID-19

COVID-19의 심각한 진행과 관련된 염증 및 항바이러스 면역 반응

Clinical Trial

Published on 2021-02-182022-08-13
Journal: Frontiers in Immunology [Category] MERS, 바이오마커, 신종인플루엔자, 유전자 메커니즘, 임상,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 applied coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 severity Disease progression disease severity downregulation Ex vivo Functional enrichment analysis H1N1 H1N1 virus healthy controls hemagglutinin host immune system hypercytokinemia IFNs immune cells immune response immune signature impair impaired function include indicate indicated Infection Inflammation Inflammatory Inflammatory response Influenza influenza A interferons LAG3 microarray analysis mild COVID-19 patient MMP9 mononuclear cell mononuclear cells myeloid cell myeloid cells Neutrophils novel respiratory disease overactivation overactive patients patients with influenza PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells potential mechanism potential mechanisms progression promote proportion Protein regulate Regulation respiratory Respiratory disease respond response SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe and mild COVID-19 patients severe COVID-19 severe SARS severe SARS-CoV-2 severity Signaling SKAP1 spike Spike protein Stimulation suggested T cell T cells T cells TLR6 Transcriptome Type I IFN type I IFNs type I interferon type I interferons unique upregulation whole genome transcriptome with COVID-19
[DOI] 10.3389/fimmu.2021.631226 PMC 바로가기 [Article Type] Clinical Trial

Human Dental Pulp Stem Cells Modulate Cytokine Production in vitro by Peripheral Blood Mononuclear Cells From Coronavirus Disease 2019 Patients

Cell and Developmental Biology

Published on 2021-02-052022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

[키워드] activated acute respiratory syndrome co-culture Concentration conditions Contact coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients cytokine dental dental pulp stem cells deregulated DPSC DPSCs form GM-CSF granulocyte healthy subject Human hyper-inflammation IFNγ IL-10 IL-12 IL-13 IL-17A IL-18 IL-1β IL-2 IL-21 IL-22 IL-23 IL-27 IL-4 IL-5 IL-6 IL-9 immune response immunomodulation in vitro interleukin investigated Macrophage mechanism mesenchymal stem cell Mesenchymal stem cells modulate modulation mononuclear cell MSC MSCs Multi-organ damage not affected Patient PBMC PBMCs peripheral Peripheral blood Pneumonia Production promote Pulp Real-time PCR Result SARS-CoV-2 STEM stem cell subset supernatant tissue regeneration TNFα
[DOI] 10.3389/fcell.2020.609204 PMC 바로가기 [Article Type] Cell and Developmental Biology