Prediction of the CYP2D6 enzymatic activity based on investigating of the CYP2D6 genotypes around the vivax malaria patients in Yunnan Province, China중국 윈난성의 열대열 말라리아 환자들에서 CYP2D6 유전자형 조사를 기반으로 한 CYP2D6 효소 활성을 예측Research Published on 2021-11-252024-08-08 Journal: Malaria Journal [Category] 말라리아, [키워드] CYP2D6 enzyme activity Genotype prediction Vivax malaria patient Yunnan Province [DOI] 10.1186/s12936-021-03988-5 PMC 바로가기 [Article Type] Research
Mental Health Interest and Its Prediction during the COVID-19 Pandemic Using Google TrendsArticle Published on 2021-11-242022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] Analysis carried changes in collected data COVID-19 COVID-19 pandemic decrease Depression expected explained expression Google Google Trends Insomnia interest loneliness Mental mental health predict predicted prediction provided psychiatrist psychologist social distancing Surveillance trend vaccination [DOI] 10.3390/ijerph182312369 PMC 바로가기 [Article Type] Article
Towards a COVID-19 symptom triad: The importance of symptom constellations in the SARS-CoV-2 pandemicResearch Article Published on 2021-11-222022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] 48 hours acute SARS-CoV-2 infection age aggregation Anosmia applied Combination confirmed case Contact cough COVID-19 patient COVID-19 symptom data-driven dataset distribution epidemiological fatigue feature Germany groups information less Linear regression model offer pandemic parameters prediction reached reported risk factor Symptom Symptoms the SARS-CoV-2 [DOI] 10.1371/journal.pone.0258649 PMC 바로가기 [Article Type] Research Article
Synthesis, Antimicrobial, Anticancer, PASS, Molecular Docking, Molecular Dynamic Simulations & Pharmacokinetic Predictions of Some Methyl β-D-Galactopyranoside AnalogsArticle Published on 2021-11-202022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] activities anticancer antimicrobial antiviral activity Bacteria binding pattern calculate Cell chloride Compound Concentration conducted COVID-19 Density functional theory dynamic FIVE fungi in silico inhibitor MBC methyl β-D-galactopyranoside MGP minimum molecular docking molecular dynamics Molecular dynamics simulation MTT Pass pharmacokinetic physicochemical physicochemical property prediction protease Simulation structures suggested synthesis the SARS-CoV-2 therapeutic target thermodynamic Toxicity was used [DOI] 10.3390/molecules26227016 PMC 바로가기 [Article Type] Article
The Prediction Model of Risk Factors for COVID-19 Developing into Severe Illness Based on 1046 Patients with COVID-19Research Article Published on 2021-11-182022-10-31 Journal: Emergency Medicine International [Category] COVID-19, [키워드] 95% CI Admission Admissions age Analysis analyzed AUC changes in chronic obstructive Clinical characteristics Clinical data Clinical symptoms collected Complication condition conditions cough COVID-19 COVID-19 patient determine develop Developing Diseases Factor hospital Hospitalization illness illnesses Intervention Logistic Logistic regression analysis Mild Model Patient patients with COVID-19 predict predicted prediction Predictive pulmonary disease regression analysis risk risk factor Risk factors ROC Curve sensitivity severe COVID-19 patient severity of COVID-19 specificity the patient threshold underlying disease underlying diseases Venous thrombosis was used with COVID-19 [DOI] 10.1155/2021/7711056 PMC 바로가기 [Article Type] Research Article
Mortality Prediction of COVID-19 Patients at Intensive Care Unit AdmissionInfectious Disease Published on 2021-11-182022-10-31 Journal: Cureus [Category] COVID-19, [키워드] absolute lymphocyte Accuracy acute respiratory distress syndrome [ards] Admission age analysed C-reactive protein Care CCI Cohort Combination Comorbidity COVID-19 COVID-19 ARDS Critical D-dimer died discharged Factor Final FIVE fraction help hospital ICU identify identifying intensive care intensive care unit IQR laboratory parameter LDH leukocyte lymphocyte median Mortality mortality prediction mortality rate multivariate logistic regression N/L ratio neutrophil non-invasive ventilation on mechanical ventilation Organ failure oxygen parameter Patient Platelet predict prediction Result Retrospective study serum creatinine serum lactate severe COVID-19 SOFA SOFA score survival the patient treat urea [DOI] 10.7759/cureus.19690 PMC 바로가기 [Article Type] Infectious Disease
Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis차등 유전자 발현 패턴 분석에 의한 COVID-19와 당뇨병 사이의 일반적인 병원성 과정 발견Case Study Published on 2021-11-172022-09-01 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] analyses Analysis biological processe biological processes blood gene expression caused characterized Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient dataset DEGs diabete diabetes Diabetes Mellitus Differential gene expression differentially expressed gene downregulated dysregulated followed by functional Functional assessment Gene ontology GO term identify implicated Increased Infectious disease involved islets modulated molecular pathways mononuclear cell mononuclear cells Ontology Organoid pancrea pancreas pathway Pathways patients with diabete PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells prediction RELA SARS-CoV-2 severity of COVID-19 T1D T2D transcription factor transcription factors transcriptional transcriptional signatures transcriptomic Treatment Type 1 diabetes type 2 diabete type 2 diabetes upregulated upregulation whole-genome [DOI] 10.1093/bib/bbab262 PMC 바로가기 [Article Type] Case Study
Machine Learning–Based Predictive Modeling of Anxiety and Depressive Symptoms During 8 Months of the COVID-19 Global Pandemic: Repeated Cross-sectional Survey StudyOriginal Paper Published on 2021-11-172022-10-31 Journal: JMIR Mental Health [Category] COVID-19, [키워드] Additive Adults affected age Algorithm Analysis Anxiety change Combination complex contributing to COVID-19 COVID-19 pandemic cross-sectional data-driven Depression distress Effect elevated emotion emotional emotional distress exacerbate exhibited explained Factor Factors flexible Gender global pandemic Gradient Health highest highlight identify Impact impacted lowest machine machine learning Measures mental health mental illness Model modeling Month objective pandemic Pandemics predicted prediction Principal component principal component analysis proportion question response Result risk sampling strategy second Sociodemographic characteristics Substance use survey Symptom Symptoms variable variables Variation was used were used [DOI] 10.2196/32876 PMC 바로가기 [Article Type] Original Paper
Algorithm for Individual Prediction of COVID-19–Related Hospitalization Based on Symptoms: Development and Implementation StudyOriginal Paper Published on 2021-11-152022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, MERS, SARS, [키워드] 95% CI Accuracy Admission age Ageusia Algorithm Algorithms Anosmia applied assist C-index calibrated Care Clinical data Comorbidities cough COVID-19 COVID-19 hospitalization COVID-19 pandemic COVID-19 patient COVID-19 severity COVID-19 testing data set database dead death develop development diagnosed with COVID-19 diarrhea died digital data discrimination Dyspnea exposure Fever headache Health health records high risk high-risk patient High-risk patients Hospital admission Hospitalization Hospitalized impacted individual Italy management medium monitoring system myalgia objective Odds ratio ordinal logistic regression outcome pandemic Patient patients patients with COVID-19 prediction prediction models Predictive primary care public health Region resource Result risk risk prediction severe outcome Sex Stratification stratified study population Symptom Symptoms vomiting with COVID-19 [DOI] 10.2196/29504 PMC 바로가기 [Article Type] Original Paper
The Effect of the COVID-19 Vaccine on Daily Cases and Deaths Based on Global Vaccine DataArticle Published on 2021-11-152022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] accelerate Administered association calculate caused collected conducted confirmed case Coronavirus disease 2019 correlation country COVID-19 COVID-19 case COVID-19 cases COVID-19 deaths Daily death distribution dose doses Effect global pandemic Meta-analysis pandemic per day prediction promote random effect reduce reduced Region second study period vaccination Vaccine Worldwide [DOI] 10.3390/vaccines9111328 PMC 바로가기 [Article Type] Article