Molecular Evolution of Human Coronavirus 229E in Hong Kong and a Fatal COVID-19 Case Involving Coinfection with a Novel Human Coronavirus 229E Genogroup홍콩에서 인간 코로나바이러스 229E의 분자 진화와 새로운 인간 코로나바이러스 229E 유전자 그룹과의 동시 감염을 포함하는 치명적인 COVID-19 사례Case Reports Published on 2021-02-102022-09-10 Journal: mSphere [Category] MERS, 진단, 치료기술, [키워드] 229E addition airway Analysis camelid circulating CLOCK Clustering Coinfection COVID-19 COVID-19 pneumonia described diagnose disease domain Evolution Genetic genetic diversity genetic drift Genome sequencing Genotype HCoV HCoV-229 HCoV-229E Hong Kong human coronavirus human coronavirus 229E human coronaviruses identity infected patients Involving N gene nasopharyngeal sample novel nucleotide path patients Pneumonia positive Positive selection RdRP Receptor-binding domain related viruses required respiratory respiratory sample retrieved SARS-CoV-2 SARS-CoV-2 strain Sequence analysis Sequencing Spike protein strain Strains tested the patient the SARS-CoV-2 the spike protein the United State The United States Transmission Travel type strain United States Viral viral evolution virus viruses Wuhan Wuhan-Hu-1 [DOI] 10.1128/mSphere.00819-20 PMC 바로가기 [Article Type] Case Reports
Molecular characterization and the mutation pattern of SARS-CoV-2 during first and second wave outbreaks in Hiroshima, Japan일본 히로시마에서 1차 및 2차 유행 중 SARS-CoV-2의 분자 특성 및 돌연변이 패턴Research Article Published on 2021-02-052022-08-13 Journal: PLoS ONE [Category] MERS, 변종, 유전자 메커니즘, [키워드] addition Amino acid amino acid change amino acid changes Analysis Asian base substitution cause Control D614G variant D614G variants defect European examined First wave GenBank GISAID Hiroshima indicated insertion Japan local outbreak local outbreaks molecular Mutation mutation rate mutations nasal swab nested PCR Next-generation sequencing nucleotide occurred ORF1a ORF1b ORF8 ORF8 protein outbreak PCR performed Phylogenetic tree predominant Primers ranged Result retrieved RT-qPCR SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains second wave sequence Seven single-nucleotide strain Strains undetectable Viral Viral load [DOI] 10.1371/journal.pone.0246383 PMC 바로가기 [Article Type] Research Article
Generalized linear models provide a measure of virulence for specific mutations in SARS-CoV-2 strains일반화된 선형 모델은 SARS-CoV-2 균주의 특정 돌연변이에 대한 독성 측정값을 제공합니다.Research Article Published on 2021-01-262022-09-10 Journal: PLoS ONE [Category] 변종, 치료법, [키워드] Alter appear approaches association conformational change conformational changes death Frequency Generalized genetic data GISAID highlight indication information Linear model Mutation mutations ORF3a Protein protein structure public health Q57H SARS-CoV-2 mutations SARS-CoV-2 strain selective significantly specific mutation specific mutations strain Viral viral strains Viral virulence virulence [DOI] 10.1371/journal.pone.0238665 PMC 바로가기 [Article Type] Research Article
Isolating SARS-CoV-2 Strains From Countries in the Same Meridian: Genome Evolutionary AnalysisOriginal Paper Published on 2021-01-222022-10-29 Journal: Jmir Bioinformatics and Biotechnology [Category] COVID-19, [키워드] 3D Structures acting affected Algorithm analyses Analysis analyzed Antiviral strategies approach Asia average binding binding probability Brazil caused change characterized clade clinical feature codon codon mutation Codons conditions country COVID-19 death Effect ENCODE ENhance epidemiological episodic selective pressure eukaryotic cells Europe Evolution Evolutionary analysis facilitate Genetic genetics Genome genomes genomic glycine help in vitro experiment initiative Isolating Italy Modification mutated Mutation North America objective ontological Ontology performed Phylogenetic tree positioned predict predicted prediction pressure Probability Protein Recombination reported Repository respiratory infection responsible Result RNA secondary structure SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 strain secondary structure selective sequence shown similarity strain Structure to define transmembrane transmembrane region turn Vaccine design virus Virus evolution wild-type [DOI] 10.2196/25995 PMC 바로가기 [Article Type] Original Paper
Critical role of neutralizing antibody for SARS-CoV-2 reinfection and transmissionSARS-CoV-2 재감염 및 전파에 대한 중화 항체의 중요한 역할Coronaviruses Published on 2021-01-192022-09-12 Journal: Emerging Microbes & Infections [Category] SARS, 진단, [키워드] addition association correlation COVID-19 demonstrated ferret ferret model group groups Heterologous Inflammatory laboratory-confirmed Lung histopathology natural immunity neutralizing antibody Primary infection Protective Region Reinfection reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain serum antibody titre Transmission upper respiratory viral clearance viral replication virus replication [DOI] 10.1080/22221751.2021.1872352 PMC 바로가기 [Article Type] Coronaviruses
An Insight Into COVID-19: A 21st Century Disaster and Its Relation to Immunocompetence and Food AntioxidantsVeterinary Science Published on 2021-01-132022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome affected angiotensin-converting enzyme 2 antigenicity antioxidants approach bat BatCoV RaTG13 binding biosecurity candidate cause coronavirus coronavirus disease COVID-19 Diagnosis disaster Effect effective effort Emergency epidemiological food Genome genomic health emergency Host host cell Human identity immune-competence immunocompetence Immunocompromised Immunopathogenesis indicated insight knowledge malaise mechanism MERS-CoV Middle East nucleotide sequence outbreak penetrate positive-sense single-stranded RNA preexisting comorbidities public health receptor relation respiratory droplet respiratory syndrome coronavirus risk SARS-CoV SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine Smokers Spike protein Spread the Betacoronavirus Treatment vaccination Vaccine viral infections Viral pneumonia virus WHO World Health Organization [DOI] 10.3389/fvets.2020.586637 PMC 바로가기 [Article Type] Veterinary Science
Earliest detection to date of SARS-CoV-2 in Florida: Identification together with influenza virus on the main entry door of a university building, February 2020Research Article Published on 2021-01-132022-10-28 Journal: PLoS ONE [Category] COVID-19, 신종인플루엔자, [키워드] Analysis circulating collected Community COVID-19 COVID-19 patient dissemination Evidence Frequency identification Influenza Influenza virus likelihood reported Sample SARS-CoV-2 SARS-CoV-2 strain sequence Sequence analysis Spread strain Strains subsequent Surveillance swab sample Transmission virus Washington [DOI] 10.1371/journal.pone.0245352 PMC 바로가기 [Article Type] Research Article
Estimating and explaining the spread of COVID-19 at the county level in the USAArticle Published on 2021-01-052022-10-04 Journal: Communications Biology [Category] MERS, 변종, [키워드] basic reproduction number communicable COVID-19 determine disease Ecological epidemiology estimate Evolutionary genetics explained Factor Infectious diseases information measure Mortality MOST Mutation outbreak Predictive public health Public health interventions R 2 reduce SARS-CoV-2 SARS-CoV-2 strain spike gene Spread spread of COVID-19 strain the epidemic the timing USA Variation [DOI] 10.1038/s42003-020-01609-6 PMC 바로가기 [Article Type] Article
Clinicopathologic correlations of COVID-19-related cutaneous manifestations with special emphasis on histopathologic patterns조직병리학적 패턴에 특히 중점을 둔 COVID-19 관련 피부 발현의 임상병리학적 상관관계Review Published on 2021-01-012022-09-11 Journal: Clinics in dermatology [Category] SARS, 치료기술, 치료제, [키워드] abundance affected association bystander clinically condition correlation COVID-19 COVID-19 pandemic current cutaneous manifestation Cutaneous manifestations Cytokines Cytokines storm eccrine glands effective Endothelial cell endothelial cells epidermis epithelial epithelial cell epithelial cells immunohistochemistry lesions manifestation multiorgan injury nasopharyngeal nosology Novel coronavirus novel coronavirus SARS-CoV-2 occur organ Patient Perspective polymerase chain real-time polymerase chain reaction reported RNA SARS-CoV-2 SARS-CoV-2 strain skin skin biopsies skin lesions skin manifestations target organs virus with COVID-19 [DOI] 10.1016/j.clindermatol.2020.12.004 PMC 바로가기 [Article Type] Review
First COVID-19 case in Zambia – Comparative phylogenomic analyses of SARS-CoV-2 detected in African countries잠비아 최초의 COVID-19 사례 - 아프리카 국가에서 발견된 SARS-CoV-2의 비교 계통 분석Case Reports Published on 2021-01-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] activity African Analysis applied B.1 B.1.1 lineage caused China Community Comparative Contact tracing country COVID-19 COVID-19 case Diagnosis Disease surveillance Epidemic epidemic disease Europe Evolution of SARS-CoV-2 France genome sequence Health care Health care worker health care workers incidence of COVID-19 individual initial Lineage lineage B.1.1 MONITOR National Novel coronavirus novel coronavirus SARS-CoV-2 phylogenetic analyses predominant preparation resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 strains South Africa Spread spread to Surveillance sustained the patient Travel while Wuhan Wuhan, China Zambia [DOI] 10.1016/j.ijid.2020.09.1480 PMC 바로가기 [Article Type] Case Reports