Higher vs Lower Doses of Dexamethasone in Patients with COVID-19 and Severe Hypoxia (COVID STEROID 2) trial: Protocol for a secondary Bayesian analysisCOVID-19 및 중증 저산소증(COVID STEROID 2) 환자에서 덱사메타손의 고용량 및 저용량 시험: 이차 베이지안 분석을 위한 프로토콜Comparative Study Published on 2021-05-012022-09-11 Journal: Acta Anaesthesiologica Scandinavica [Category] SARS, 임상, [키워드] adjusted analysed Analysis Bayesian analysis binary outcome clinically Clinicians conducted coronavirus disease Coronavirus disease 2019 Corticosteroids COVID COVID-19 credibility interval Critically ill Critically ill patient days alive death decrease Dexamethasone Effect help hypoxia hypoxic respiratory failure incidence rate Interpretation intravenously logistic regression model logistic regression models Lower lower dose mean difference Mortality optimal dose outcome patients with COVID-19 Primary outcome Probability protocol randomised Registered researcher Respiratory failure risk secondary outcome Sensitivity analyses sensitivity analysis severe hypoxia statistical steroid Stratification Support the mean Trial variable with COVID-19 [DOI] 10.1111/aas.13793 PMC 바로가기 [Article Type] Comparative Study
Hybrid physiologically-based pharmacokinetic model for remdesivir: Application to SARS-CoV-2렘데시비르에 대한 하이브리드 생리학적 기반 약동학 모델: SARS-CoV-2에 적용Article Published on 2021-05-012022-09-11 Journal: Clinical and translational science [Category] SARS, 치료제, [키워드] anti-SARS-CoV-2 Antiviral agents application can be used catastrophic caused Concentration condition conducted coronavirus disease Coronavirus disease 2019 COVID-19 determine effective Extracellular half-maximal effective concentration Health humans hybrid impacted imperative in vitro indicated lung Lungs metabolite mononuclear cell Multiple-dose Novel coronavirus pandemic parameter patients Peripheral blood Peripheral blood mononuclear cells pharmacokinetic prodrug profiles ranged RDV regimen regimens Remdesivir reported SARS-CoV-2 sensitivity analysis Severe acute respiratory syndrome target tissues Therapeutic treatment tissue [DOI] 10.1111/cts.12975 PMC 바로가기 [Article Type] Article
6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health recordsArticles Published on 2021-05-012022-10-30 Journal: The lancet. Psychiatry [Category] COVID-19, MERS, SARS, [키워드] 95% CI Admission affected Analysis Anxiety Anxiety Disorder Brain category Cohort cohorts cohorts of patient COVID-19 COVID-19 cohort COVID-19 diagnosis COVID-19 infection COVID-19 severity Cox model delirium Dementia diagnose diagnosed diagnosed with COVID-19 Diagnosis diagnosis of COVID-19 diagnostic disorder disorders Effect Electronic health record Encephalopathy estimate events Evidence explain finding funding had more hazard ratio Health help hospitalisation incidence incidence rate Infection Influenza information Insomnia Intensive investigated ischaemic stroke morbidity MOST neurological NIHR outcome Oxford Parkinsonism Patient patients patients older Positive test provide Psychiatric psychiatric diagnose psychiatric diagnosis receiving reported Research respiratory tract infection Respiratory tract infections Result retrospective cohort study risk robust SARS-CoV-2 sensitivity analysis severe COVID-19 study outcomes Substance use survivor therapy time-to-event analysis used data were excluded [DOI] 10.1016/S2215-0366(21)00084-5 PMC 바로가기 [Article Type] Articles
Sex differences in the case-fatality rates for COVID-19—A comparison of the age-related differences and consistency over seven countriesResearch Article Published on 2021-04-292022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] age agency Canada CFR CFRs conducted country COVID-19 COVID-19 pandemic death Denmark Diseases England estimate evaluate examined Factor female females greater heterogeneity incidence Italy magnitude male mechanism meta-analytic method meta-regression Mortality National patients Prevalence Result sensitivity analysis Seven severity of COVID-19 Sex Sex difference Spain the disease underlying disease were used [DOI] 10.1371/journal.pone.0250523 PMC 바로가기 [Article Type] Research Article
Construction of a demand and capacity model for intensive care and hospital ward beds, and mortality from COVID-19코로나19로 인한 중환자실 및 병상 병상 수요 및 용량 모델 구축Research Published on 2021-04-272022-09-10 Journal: BMC Medical Informatics and Decision Making [Category] 변종, [키워드] Admission B.1.1.7 best Capacity Care Combination construction COVID-19 death deaths Demand described England expected Government hospital hospital ward ICU in some increase in increased mortality increasingly indicated Infectious diseases information intensive care intensive care unit lack Local Model Mortality National number of deaths observation parameter public health reduction required Result sensitivity analysis subsequent supplementary material variant was used were used [DOI] 10.1186/s12911-021-01504-y PMC 바로가기 [Article Type] Research
Construction of a demand and capacity model for intensive care and hospital ward beds, and mortality from COVID-19Research Published on 2021-04-272022-10-27 Journal: BMC Medical Informatics and Decision Making [Category] COVID-19, [키워드] Admission Capacity Care Combination construction COVID-19 death deaths Demand described England expected Government hospital hospital ward ICU increase in increased mortality increasingly indicated Infectious diseases information intensive care lack Local Model Mortality National observation parameter public health reduction required Result sensitivity analysis subsequent supplementary material variant was used were used [DOI] 10.1186/s12911-021-01504-y PMC 바로가기 [Article Type] Research
Construction of a demand and capacity model for intensive care and hospital ward beds, and mortality from COVID-19Research Published on 2021-04-272022-10-27 Journal: BMC Medical Informatics and Decision Making [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] Admission Capacity Care Combination construction COVID-19 death deaths Demand described England expected Government hospital hospital ward ICU increase in increased mortality increasingly indicated Infectious diseases information intensive care lack Local Model Mortality National observation parameter public health reduction required Result sensitivity analysis subsequent supplementary material variant was used were used [DOI] 10.1186/s12911-021-01504-y PMC 바로가기 [Article Type] Research
Simulated Identification of Silent COVID-19 Infections Among Children and Estimated Future Infection Rates With Vaccination예방 접종으로 어린이의 침묵하는 COVID-19 감염의 시뮬레이션된 식별 및 예상 미래 감염률Research Published on 2021-04-232022-09-10 Journal: JAMA Network Open [Category] MERS, SARS, 치료기술, 치료제, [키워드] 24 hour 24 hours absence addition Adults age analyzed approach asymptomatic stage attack rate attack rates benefit children Combination combinations comparable Course Coverage COVID-19 COVID-19 infection COVID-19 infections COVID-19 transmission COVID-19 vaccination disease disease transmission driver Effect effective Efficacy estimate Estimated exposure finding Future General population group identification identify Importance Infection infection rate infections Intervention Isolation less measure mitigate objective occur Older outbreak participant Point presymptomatic proportion Rate reduced reducing Relevance remained Reproduction number Result robust Sensitivity analyses sensitivity analysis setting severe COVID-19 significantly silent silent infection silent infections speed suppress susceptibility symptom onset symptomatic symptomatic case symptomatic cases synergistic synergistic effect Transmission unlikely vaccination Vaccine vaccine availability vaccine efficacy [DOI] 10.1001/jamanetworkopen.2021.7097 PMC 바로가기 [Article Type] Research
Remdesivir for treatment of COVID-19; an updated systematic review and meta-analysisCOVID-19 치료를 위한 렘데시비르; 업데이트된 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-04-152022-09-11 Journal: European journal of pharmacology [Category] 임상, 치료법, 치료제, [키워드] 95%CI administration ADR ADRS Adverse drug reaction Adverse drug reactions approval approved benefit bioRxiv Clinical improvement Cochrane Library controlled trials coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patients COVID-19 treatment Direct Drug administration Efficacy and safety evaluate Evidence extracorporeal membrane oxygenation FDA FIVE follow-up time Google Scholar Health Health crisis Intervention Invasive mechanical ventilation median medRxiv Meta-analysis non-randomized study oxygen oxygen support pandemic performed Performing provided Randomized controlled trial RCT RCTs regimen Remdesivir risk SARS-CoV-2 Science Science Direct scientific evidence sensitivity analysis significantly lower systematic literature search systematic review Treatment was done Web of Science [DOI] 10.1016/j.ejphar.2021.173926 PMC 바로가기 [Article Type] Meta-Analysis
Impact of early detection and vaccination strategy in COVID-19 eradication program in Jakarta, IndonesiaResearch Note Published on 2021-04-122022-10-27 Journal: BMC Research Notes [Category] COVID-19, MERS, [키워드] Asymptomatic basic reproduction number can be used Contact Contact tracing Coronavirus disease 2019 COVID-19 COVID-19 vaccine Endemic Factor Factors Government Impact include Indonesia Jakarta mathematical mechanism objective predict rapid testing reducing Result sensitivity analysis social distancing spread of COVID-19 vaccination vaccination rate Vaccination strategy [DOI] 10.1186/s13104-021-05540-9 PMC 바로가기 [Article Type] Research Note