Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2SARS-CoV-2에 대해 설계된 단백질 나노입자 백신에 의한 강력한 중화 항체 반응의 유도Article Published on 2020-11-252022-09-12 Journal: Cell [Category] Fulltext, SARS, 비임상, 진단, [키워드] antibody Antibody Response Antigen cGMP clinical trial computational protein design convalescent displaying domain ectodomain effective effort elicit elicited Epitopes highlight human sera immunogen immunogenic induce lower dose mice mutations nanoparticle Neutralizing antibody response Neutralizing antibody titer non-overlapping epitope platform potent Protective protective antibody response Protein RBD RBDs Receptor-binding domain Respiratory disease response risk robust Safe SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 spike SARS-CoV-2 vaccine SARS-CoV-2-RBD stability structure-based design susceptible the RBD the SARS-CoV-2 trimer utility Vaccine vaccine candidate vaccine for COVID-19 virus wall [DOI] 10.1016/j.cell.2020.10.043 PMC 바로가기 [Article Type] Article
Interferon β-1a (IFNβ-1a) in COVID-19 patients (INTERCOP): study protocol for a randomized controlled trialCOVID-19 환자의 인터페론 β-1a(IFNβ-1a)(INTERCOP): 무작위 대조 시험을 위한 연구 프로토콜Study Protocol Published on 2020-11-232022-08-13 Journal: Trials [Category] SARS, 임상, [키워드] 7-point ordinal scale addition Administered ameliorated animal model animal models anti-viral activity anti-viral drug antibody biochemical marker biochemical markers blood cell blood cell counts changes in clinical benefit clinical benefits clinical severity score clinical status clinical trial Combination Computed tomography cornerstone coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 treatment cytokine death dose Efficacy EudraCT Evidence evidence of Hospital stay Identifier IFNβ-1a IFNβ IFNβ-1a implication in vitro include indicated Inflammatory intensive care intensive care unit INTERCOP INTERCOP trial interferon interferon-stimulated genes International international units intervention arms mild-to-moderate disease moderate disease Mortality mRNA expression profile nasopharyngeal swabs Negative conversion Open-label Ordinal Scale organ dysfunction outcome oxygen oxygen- Patient Pneumonia positive swab Potential Primary outcome pulmonary computed tomography pulmonary computed tomography severity score radiological Randomized Randomized controlled trial rationale reduce reduced reduction regimens Safe SARS-CoV-2 SARS-COV-2 infection secondary Secondary outcomes Serious Adverse Events severity Standard of care Study protocol subcutaneously therapeutic therapy transfer Treatment Trial Trial registration Ventilator-free days Viral Viral load worsening [DOI] 10.1186/s13063-020-04864-4 PMC 바로가기 [Article Type] Study Protocol
Wide-awake local anaesthesia no tourniquet (WALANT) vs regional or general anaesthesia for flexor tendon repair in adults: protocol for a systematic review and meta-analysis성인의 굴곡건 수복을 위한 WALANT(광각성 국소마취 무지혈대) 대 국소 또는 전신 마취: 체계적인 검토 및 메타 분석을 위한 프로토콜Protocol Published on 2020-11-212022-08-31 Journal: Systematic Reviews [Category] Coronavirus, meta-analysis, SARS, [키워드] (epinephrine Abstract Adrenaline Aerosol generation anaesthesia Anaesthetics approach article best CINAHL clinical trial Cochrane Library comparator complications conducted conscious COVID-19 database determine epinephrine evaluate Evidence feasible Finger injuries Flexor tendon Flexor tendon injury flexor tendons functional general anaesthesia Grey Grey literature hand Hand injuries hand surgery healthcare professionals help IMPROVE include Injury intubation investigator knowledge language limitation Local Meta-analysis Methodological quality motion occur open operative time outcome outcome measures Patient peer review Penetrating penetrating injury Potential Primary outcome protocol random effect range of motion reduced reduced risk Referral Registered removal repair required resolved resource risk secondary Secondary outcomes spread to standard treatment Study protocol supplementary material surgeon surgery surgical systematic review Tendon injuries tourniquet undergo WALANT Wide-awake Wide-awake local anaesthesia no tourniquet wrist [DOI] 10.1186/s13643-020-01532-1 PMC 바로가기 [Article Type] Protocol
Food Ingredients and Active Compounds against the Coronavirus Disease (COVID-19) Pandemic: A Comprehensive ReviewReview Published on 2020-11-202022-11-01 Journal: Foods [Category] COVID-19, [키워드] absence accelerated arising benefit clinical study clinical trial Compound compounds Comprehensive COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 transmission Evidence food Functional foods help heterogeneity Human hypothese immune function immune response immune system Inconclusive Infection information ingredient inhibitors of SARS-CoV-2 media Numerous nutraceutical nutraceuticals outcome polysaccharide Prophylaxis PROTECT Randomized review SARS-CoV-2 severity suggested Support Treatment Variability Vitamin D vitamin D level [DOI] 10.3390/foods9111701 PMC 바로가기 [Article Type] Review
Potency and timing of antiviral therapy as determinants of duration of SARS-CoV-2 shedding and intensity of inflammatory responseSARS-CoV-2 배출 기간 및 염증 반응의 강도를 결정하는 항바이러스 요법의 효능 및 시기Article Published on 2020-11-202022-09-11 Journal: Science Advances [Category] SARS, 진단, 치료제, [키워드] Affect antiviral therapies antiviral therapy AUC cellular Clinical severity clinical trial clinical trials COVID-19 COVID-19 pandemic decrease determinant develop dosed driven by drug drug resistance early treatment immune response Immunotherapy in vivo Infection Inflammatory response intensity mathematical Mathematical models Neutralizing antibodies performed potency potent predict Predictive presymptomatic Remdesivir SARS-CoV-2 selinexor Support Symptom therapeutic approaches therapy Treatment Viral viral dynamics Viral load viral loads [DOI] 10.1126/sciadv.abc7112 PMC 바로가기 [Article Type] Article
COVID-19 and Hyperimmune sera: A feasible plan B to fight against coronavirusReview Published on 2020-11-202022-11-01 Journal: International immunopharmacology [Category] COVID-19, MERS, SARS, [키워드] Abstract Animal antibodies animal model anti-inflammatory agent anti-SARS-CoV-2 Antigen Antiviral Clinical studies clinical trial convalescent convalescent plasm coronavirus COVID-19 COVID-19 pandemic death rate donors effective evaluated feasible Heterologous hyperimmune Hyperimmune sera hyperimmune serum indicated investigated neutralizing titers phase 2/3 protein S protocol RBD recent finding SARS-CoV-2 SARS-CoV-2 S protein sera serum shown the receptor-binding domain therapeutic Treatment treatment strategy trimeric Vaccine Vaccine hesitancy vaccine production [DOI] 10.1016/j.intimp.2020.107220 PMC 바로가기 [Article Type] Review
Niacinamide May Be Associated with Improved Outcomes in COVID-19-Related Acute Kidney Injury: An Observational StudyObservational Study Published on 2020-11-202022-10-05 Journal: Kidney360 [Category] 임상, [키워드] 95% CI acute kidney Acute kidney injury acute kidney injury and ICU nephrology acute renal failure AKI Algorithms association baseline Care clinical trial comparable coronavirus disease COVID-19 creatinine criteria death dialysis driven by effective therapy Efficacy evaluate Evidence hospital Hospitalized ICU Improved Improving Interaction KDIGO lower risk Mortality multivariable NAD+ niacinamide outcome outcomes Patient patients patients died per day Primary outcome protocol randomized study renal RRT SARS-CoV-2 SEM therapy Total trajectory Treatment vitamin B3 vitamin B3. [DOI] 10.34067/KID.0006452020 PMC 바로가기 [Article Type] Observational Study
Coronavirus Disease 2019 (COVID-19) Clinical Trial Oversight at a Major Academic Medical Center: Approach of Michigan Medicine코로나바이러스 질병 2019(COVID-19) 주요 학술 의료 센터의 임상 시험 감독: 미시간 의학의 접근Article Published on 2020-11-192022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] 임상, [키워드] absence best Care clinical clinical trial clinician Controlled clinical trial controlled clinical trials coronavirus disease Coronavirus disease 2019 Coverage COVID-19 determine Efficacy Ethics Evidence Informed consent Intervention lack Major media Medicine offer outbreak Patient provided Randomized randomized clinical trial receiving recruitment Research Research Ethics robust subject treat Trial [DOI] 10.1093/cid/ciaa560 PMC 바로가기 [Article Type] Article
COVID-19 Clinical Trials Registered Worldwide for Drug Intervention: An Overview and Characteristic Analysis약물 중재를 위해 전 세계적으로 등록된 COVID-19 임상 시험: 개요 및 특성 분석Review Published on 2020-11-192022-09-11 Journal: Drug design, development and therapy [Category] 신약개발, 임상, 치료제, [키워드] accounted allocation Blinding Characteristics clinical Clinical efficacy clinical trial clinical trials contributing to country COVID-19 drug drug names drug treatments drug trial drug trials drugs Efficacy Enrollment evaluate evaluated Evidence exceeded expected facilitate Hydroxychloroquine implementation interquartile range Intervention investigation less mapped median over Participants randomization recruitment Registered retrieved Retrospective analysis reuse the United State Treatment Trial trials United States [DOI] 10.2147/DDDT.S281700 PMC 바로가기 [Article Type] Review
Status of Institutional Review Board Meetings Conducted Through Web Conference Systems in Japanese National University Hospitals During the COVID-19 Pandemic: Questionnaire StudyOriginal Paper Published on 2020-11-192022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, [키워드] Administered carried clinical trial conducted Conference COVID-19 COVID-19 disease COVID-19 pandemic Drug development highlight hospital hospitals IMPROVE institutional review board introduced IRB IRBs Japan Japanese lifted measure meeting National objective Pandemics problem proliferation protocol Randomized controlled trial REB required Research Ethics Board respond respondent Result shown status suggested survey System teleconference university was performed was used Web web conference [DOI] 10.2196/22302 PMC 바로가기 [Article Type] Original Paper