The next frontier in vaccine design: blending immune correlates of protection into rational vaccine designReview Published on 2022-10-012022-10-05 Journal: Current opinion in immunology [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, [키워드] accelerate accelerated antibody Antibody binding canonical Community Complete death embedding immune correlate Immune profile Immunity immunological lack neutralization pathogen populations protective vaccines question raised severe disease the vaccine to define Vaccine Vaccine design Vaccine development Vaccines variants of concern Viral variants waned [DOI] 10.1016/j.coi.2022.102234 [Article Type] Review
The way forward for neuroethics in Japan: A review of five topics surrounding present challengesReview article Published on 2022-10-012022-10-05 Journal: Neuroscience Research [Category] 비임상, [키워드] Brain comparison Contact FIVE Human identity Impact intervene introduced Japan Japanese methodology Neuroethics non-human primates Perspective Psychiatric public health Research rule Support [DOI] 10.1016/j.neures.2022.07.006 [Article Type] Review article
Activity of ertapenem/zidebactam (WCK 6777) against problem EnterobacteralesArticle Published on 2022-09-302022-11-16 Journal: Journal of Antimicrobial Chemotherapy [Category] SARS, 비임상, [키워드] 1:1 active against activity administration breakpoint Dilution E. coli Escherichia coli evaluated experiments group healthcare increasingly indicated Infection inhibited isolate Klebsiella KPC Laboratory material MDR National nosocomial Outpatient over Parenteral pathogen Patient proportion regimen SARS-CoV-2 secondary submitted Support susceptibility Trial will drive [DOI] 10.1093/jac/dkac280 PMC 바로가기
MiRNA-SARS-CoV-2 dialogue and prospective anti-COVID-19 therapiesMiRNA-SARS-CoV-2 대화 및 전향적인 항-COVID-19 치료법Review Published on 2022-09-152022-09-11 Journal: Life sciences [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 비임상, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adverse effect adverse effects Affect antiviral response approach approved Biomarker caused Cell signaling chance Clinical significance Comorbidities coronavirus Coronavirus-2 country COVID-19 COVID-19 illness COVID-19 infection COVID-19 pathogenesis COVID-19 patient Critical death detect differential expression disease disease onset disease pathology effort etiology expression FDA focus Host host cell host inflammatory response host miRNA host miRNAs identify Infection life cycle microRNA miRNA miRNAs molecular interaction non-coding RNA offer pathogen Pathogen-host interaction patients with COVID-19 post-transcriptionally quest reduce respiratory respond RNA RNA silencing SARS Coronavirus SARS coronavirus 2 SARS coronavirus 2. SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity Signaling target gene the SARS-CoV-2 virus therapy treat Treatment Viral viral miRNA viral miRNAs [DOI] 10.1016/j.lfs.2022.120761 PMC 바로가기 [Article Type] Review
A universal SARS-CoV DNA vaccine inducing highly cross-reactive neutralizing antibodies and T cellsArticle Published on 2022-09-022022-11-15 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 바이오마커, 변종, 비임상, 진단, [키워드] antibody Beta contagious cross-reactive Delta DNA vaccine domain evade functional Human human ACE2 receptor Immunity induce lethal disease lethal infection membrane mice neutralized neutralizing antibody New observation omicron pandemic priming PROTECT Protective SARS-CoV SARS-CoV vaccine SARS-CoV-2 Spike protein T cell T cells the SARS-CoV-2 Vaccine Vaccine development Vaccines variant variants virus WHO [DOI] 10.15252/emmm.202215821 PMC 바로가기
Patients with infectious diseases undergoing mechanical ventilation in the intensive care unit have better prognosis after receiving metagenomic next-generation sequencing assayResearch article Published on 2022-09-012022-10-05 Journal: International Journal of Infectious Diseases [Category] 비임상, [키워드] 28-day mortality Analysis analyzed approaches assays assigned baseline Concordance Culture diagnostic evaluate Health hypertension ICU Immunosuppressed independent risk factor Infectious disease intensive care intensive care unit mechanical ventilation medical record metagenomic Metagenomic next-generation sequencing Mortality Next-generation sequencing objective on mechanical ventilation pathogen Pathogens diagnosis Patient polymerase chain Prognosis prognosis of patient receiving reducing Result severe pneumonia single-center the patient traditional methods [DOI] 10.1016/j.ijid.2022.07.062 [Article Type] Research article
Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer’s disease용도 변경 항암 표피 성장 인자 수용체 억제제: 알츠하이머 병에서 신경 보호 효과의 메커니즘Review Published on 2022-09-012022-09-11 Journal: Neural Regen Res [Category] 비임상, [키워드] Alzheimer's disease Alzheimer’s disease animal model autophagy breath caused disease Disease progression downstream signaling pathway downstream signaling pathways drug drug re-positioning Effect effective enhancement epidermal epidermal growth factor epidermal growth factor receptor Evidence examined explained growth factor human epidermal growth factor receptor-2 kinase inhibitors mechanism modulation molecular mechanism neurodegeneration neurodegenerative Neurodegenerative diseases Neuroinflammation neurological manifestation neurological manifestations Numerous oxidative oxidative stress Perspective positioning Prospective clinical trial recent receptor receptor inhibitor Research shown signaling pathways therapeutic approach tyrosine tyrosine kinase inhibitors Tyrosine kinase inhibitors. [DOI] 10.4103/1673-5374.332132 PMC 바로가기 [Article Type] Review
High-Dose versus Low-Dose Corticosteroids in COVID-19 Patients: a Systematic Review and Meta-analysisResearch article Published on 2022-09-012022-10-05 Journal: Journal of cardiothoracic and vascular anesthesia [Category] COVID19(2023년), SARS, 비임상, 임상, [키워드] Admission Analysis certainty of evidence Clinical efficacy coronavirus Corticosteroid Corticosteroids COVID-19 COVID-19 patients demonstrated Dexamethasone did not reduce dose evaluate Evidence group heterogeneity High-dose higher risk Hospital stay hyperglycemia ICU IMPROVE incidence Inconclusive infection rate intensive care low-dose corticosteroid low-dose corticosteroids measurement mechanical ventilation Meta-analysis Methylprednisolone mortality rate no significant difference objective observational study participant patients positive randomized clinical trial Randomized controlled trial Respiratory Support Result review SARS-CoV-2 SARS-CoV-2 PCR setting significant difference systematic review Trial trial sequential analysis [DOI] 10.1053/j.jvca.2022.05.011 [Article Type] Research article
SARS-CoV-2 and the central nervous system: Emerging insights into hemorrhage-associated neurological consequences and therapeutic considerationsReview article Published on 2022-09-012022-10-05 Journal: Ageing research reviews [Category] COVID19(2023년), SARS, 비임상, [키워드] ACE2 angiotensin-converting enzyme 2 association Blood Brain brain fog cause caused cells cellular senescence comorbid conditions consequence Consequences coronavirus coronavirus 2 Coronavirus disease 2019 COVID COVID-19 Critical death Degradation Diseases event Ferroptosis Genome Genome instability hemorrhage hemorrhagic damage Increases individual lesion likelihood multi-organ failure neurodegenerative neurological Neurological complications Neurovascular occur organ pathology predisposition prognostic raise respiratory SARS-CoV-2 SARS-COV-2 infection senescence shown Strains Survivors systemic inflammation target therapeutic Therapeutic strategies widespread [DOI] 10.1016/j.arr.2022.101687 [Article Type] Review article
New challenges in human monkeypox outside Africa: A review and case report from ItalyReview article Published on 2022-09-012022-10-05 Journal: Travel medicine and infectious disease [Category] 비임상, 원숭이두창, [키워드] Anal Case report caused confirmed case Contact diagnosed Diagnosis disease DNA virus double-stranded Endemic HIV Human human-to-human transmission Italian Italy men Monkeypox New orthopoxvirus outbreak PCR Portugal positive Poxviridae responsible rodent Sample Sex Singapore skin lesions the United State United Kingdom USA Viral load virus virus infection zoonotic disease [DOI] 10.1016/j.tmaid.2022.102386 [Article Type] Review article