Expression and Purification of a PEDV-Neutralizing Antibody and Its Functional VerificationArticle Published on 2021-03-122022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] antibodies antibody demonstrated epidemic diarrhea eukaryotic expression vector experiment expressed Genes HEK293 cell Immunity Infection inhibited monoclonal antibody morbidity and mortality neutralized neutralizing antibody Newborn oral administration pathogenic virus PEDV problem produced S protein Side effects Strains supernatant Vaccines Variation verification virus [DOI] 10.3390/v13030472 PMC 바로가기 [Article Type] Article
High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme고친화성 나노바디는 SARS-CoV-2 스파이크 수용체 결합 도메인과 인간 안지오텐신 전환 효소의 상호작용을 차단합니다Article Published on 2020-12-222022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antibody fragment approved Biochemistry block COVID-19 pandemic derivative diagnostic Drug development effective enzyme expressing form HEK293 cell HEK293 cells high affinity human ACE2 Infection inhalation Interaction lead lentivirus Medical research nanobodies nanobody nebulization potency Proteins pseudotyped Receptor binding domain responsible SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein receptor binding domain Spike protein the SARS-CoV-2 the spike protein therapeutic Treatment variant virus [DOI] 10.1038/s41598-020-79036-0 PMC 바로가기 [Article Type] Article
CNNM2 Mutations Cause Impaired Brain Development and Seizures in Patients with HypomagnesemiaCNNM2 돌연변이는 저마그네슘혈증 환자의 뇌 발달 장애 및 발작을 유발합니다Research Article Published on 2014-04-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accompanied Affect Brain brain development brain malformation brain malformations cation channel cause caused Cell cellular clinical variability CNNM2 Combination cRNA cyclin M2 de novo de novo heterozygous missense mutations demonstrated development Diagnosis disease Effect embryonic explain expressing FIVE gene encoding Genetic genetic cause genetic component genetic disease genetic etiology genetic heterogeneity handling HEK293 cell HEK293 cells heterozygous homeostasis human disease hypomagnesemia identify Impaired IMPROVE in vitro activity increase inheritance injection intellectual disability isoform kidney knockdown loss-of-function Magnesium mammalian Mental mental disability mental retardation Missense mutation mutant mutated Mutation neurodevelopmental impairment neurodevelopmental impairments neurological Neurological diseases occur Pathomechanism Pathomechanisms Patient patients with moderate phenotype Phenotypes physiological Physiology Protein reduced Regulation renal rescued Seizure Seizures shown the disease therapeutic drug Treatment TRPM7 unique wild-type zebrafish [DOI] 10.1371/journal.pgen.1004267 PMC 바로가기 [Article Type] Research Article