Common variants at 21q22.3 locus influence MX1 and TMPRSS2 gene expression and susceptibility to severe COVID-19Research article Published on 2021-04-232022-10-05 Journal: iScience [Category] 유전자 메커니즘, [키워드] advanced age association Blood chromosome 21 clinical presentation Common variant Comorbidities Control coronavirus disease correlated COVID-19 disease European explain expression Factor FIVE Gene Expression Genetic genetic analysis genetic factor genetics Genome-wide association study Genomics Hospitalized Host host antiviral response implicated individual initiative locus Male sex Manifestations minor allele MX1 Pathogenesis performed potential therapeutic target reduced risk risk factor severe COVID-19 Single nucleotide polymorphism SNPs susceptibility TMPRSS2 [DOI] 10.1016/j.isci.2021.102322 [Article Type] Research article
Differentially expressed immune response genes in COVID-19 patients based on disease severity질병 중증도에 따라 COVID-19 환자에서 차등적으로 발현되는 면역 반응 유전자Research Paper Published on 2021-04-152022-09-10 Journal: Aging (Albany NY) [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Antiviral antiviral genes APOBEC3G Apolipoprotein Apolipoprotein B appear blood sample Blood samples case-control study catalytic changes in chemokine chemokines city collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CXCL10 CXCL11 CXCL9 cytokine Cytokines death decreased expression disease Disease progression disease severity domain downregulated dysregulated immune response dysregulated immune responses enzyme expressed FADD Gene Expression genes encoding healthy control healthy controls healthy subject Host IFN IFNA1 IFNA2 IFNAR1 IL12A IL12B IL15 IL1B IL6 Illness severity immune response gene immune response genes immune responses induction IRF7 ISG15 microRNA mRNA MX1 Patient patients PCR progression Proinflammatory cytokine proinflammatory cytokines Protein recovered COVID-19 patient recruited respiratory RNA extraction SARS-CoV-2 SARS-COV-2 infection second severe acute respiratory syndrome Coronavirus Signaling significantly thought TLR8 TLR9 type I interferon underlie upregulated [DOI] 10.18632/aging.202877 PMC 바로가기 [Article Type] Research Paper
Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus MacaquesSARS-CoV-2에 감염된 붉은털 원숭이의 혈관 질환 및 혈전증Case Reports Published on 2020-11-252022-09-11 Journal: Cell [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Analysis Bronchoalveolar lavage C-reactive protein clinical Clinical features Coagulation collagen complement COVID-19 COVID-19 pandemic Critical endothelial feature Human IFNα IL-1 IL-6 IL-8 include infected with SARS-CoV-2 Inflammation Inflammatory Interaction lead lung Lungs macaque macaques Macrophage molecular morbidity and mortality MX1 NF-κB pathway performed Peripheral blood Platelet platelet activation potential therapeutic target potential therapeutic targets proinflammatory proteomic rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 pathogenesis serum thrombosis TNFα transcriptomic Transcriptomic analyses upregulation Vascular vascular disease vascular thrombosis vWF [DOI] 10.1016/j.cell.2020.10.005 PMC 바로가기 [Article Type] Case Reports
Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19Article Published on 2020-10-292022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] activated Algorithm Analysis APOC1 ApoE BAL BCL2A1 Bronchoalveolar lavage Bronchoalveolar lavage (BAL) C1QB canonical category CCL2 CCL3 CCL5 CCL8 CCR1 Cell cellular chemotactic chemotaxis circulation Clustering Cohort complex coronavirus disease correlation COVID-19 CXCL8 Cytokine storm dataset diagnostic disease severity downregulated EPSTI1 FABP4 FIVE FPR1 functional gene signature gene signatures hallmark healthy subject healthy subjects ICGS2 identify IFI27 IFI30 Ifi44 IFI44L IFI6 IFIT1 IFIT3 IFITM1 IFITM2 IFITM3 IFNg IL17 IL1A IL1B IL1RN immune Immune cell Inflammatory inflammatory macrophages Inflammatory response interstitial iterative KLF6 Macrophage MALAT1 Mild mononuclear cell MX1 myeloid cells NEAT1 neutrophil Neutrophils NFkB OAS1 OAS2 OAS3 OASL pathway Patient patients PBMCs Peripheral blood phagocytes phagocytosis PLSCR1 PRL reduction reflected role S100A8 SARS-CoV-2 SAT1 several gene severe COVID-19 severity Signaling Single Cell SPP1 STAT3 subset suppressed systemically TGM2 therapeutic interventions TLR7 TLR9 TNF TYMP UMAP upstream with COVID-19 [DOI] 10.3390/cells9112374 PMC 바로가기 [Article Type] Article
SAMHD1 as the Potential Link Between SARS-CoV-2 Infection and Neurological ComplicationsNeurology Published on 2020-09-252022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome ADAR angiotensin-converting enzyme 2 bioinformatics BST2 caused cells chemokines clinical symptom Complication complications of COVID-19 coronavirus correlation CoV COVID-19 COVID19 CoVs Cytokines death Dipeptidyl peptidase 4 dissemination DPP4 event expression globe IFITM3 Infection influenza A virus IRF3 ISG15 mechanism MERS-CoV Middle East morbidity MX1 MX2 neurodegeneration neuroinvasion neurologic neurological Neurological complication Neurological symptoms NF-κB pathway other molecule pandemic Pathogenesis peripheral nerve system Pneumonia Potential produced Prognosis receptor respiratory syncytial virus RNASEL robust RSAD2 SAMHD1 SAR-CoV2 SARS-CoV-1 SARS-CoV-2 Spread STRING syndrome text mining triggered Type type III interferon with COVID-19 [DOI] 10.3389/fneur.2020.562913 PMC 바로가기 [Article Type] Neurology
Protein Coding and Long Noncoding RNA (lncRNA) Transcriptional Landscape in SARS-CoV-2 Infected Bronchial Epithelial Cells Highlight a Role for Interferon and Inflammatory ResponseArticle Published on 2020-07-072022-10-31 Journal: Genes [Category] COVID-19, SARS, [키워드] activated Activation acute inflammatory response acute respiratory syndrome Analysis Antiviral antiviral response bioinformatics Biomarkers bronchial bronchial epithelial bronchial epithelial cell category caused Cell cell death cells Community coronavirus Course COVID-19 differentially expressed disease expressed gene expression functional functional annotation gene expressions gene target hallmark highlight host cells host response Ifi44 IFI44L IFIT1 IFIT2 IFIT3 IFITM1 IFN IFN response IgG immune response Immunoglobulin in vitro induction Infection innate response interferon Interferon lambda investigated involved IPA IRF9 landscape lncRNA lncRNAs Long long noncoding RNA lung tissue MAPK MX1 Necrosis network analysis NHBE OAS2 OAS3 Ontology pathogenesis of COVID-19 pathogenic Pathway analysis Patient Replication Research response RNA role SARS-CoV-2 SARS-COV-2 infection spread of COVID-19 suppressed tissue TNF Transcriptome upregulated upstream viral infection Viral protein with COVID-19 [DOI] 10.3390/genes11070760 PMC 바로가기 [Article Type] Article
MicroRNA-221-5p Inhibits Porcine Epidemic Diarrhea Virus Replication by Targeting Genomic Viral RNA and Activating the NF-κB PathwayArticle Published on 2018-10-292022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, [키워드] 3’ UTR 3′ untranslated region activate activating biological processes cause Critical cytokine signaling demonstrated dose-dependent manner economic loss epidemic diarrhea etiological agent expression Gene Expression genomic RNA in viral Infection inhibit inhibited Innate immunity interferon investigated involved microRNA-221-5p miRNA miRNAs MX1 NF-κB NF-κB NF-κB pathway noncoding RNA nuclear nuclear translocation overexpression p65 pathway PEDV porcine epidemic diarrhea virus (PEDV) previous study Regulation Regulatory Replication reported RNA Signaling target targeting targets therapeutic strategy upregulating UTR viral genome viral replication virus [DOI] 10.3390/ijms19113381 PMC 바로가기 [Article Type] Article
Expression profiles of immune mediators in feline Coronavirus-infected cells and clinical samples of feline Coronavirus-positive catsResearch Article Published on 2017-04-072022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] addition cause CCL8 Cell clinical sample clinically coronavirus CrFK CXCL10 cytokine definitive diagnosis examined expected expression expression profile fatal disease Feline coronavirus GM-CSF IFNγ IL1β IL6 IL8 immune Immune-mediators immunoassay increase in kidney MCP1 multiplex MX1 PBMC performed plasma pro-inflammatory cytokine profile provide RANTES Real-time PCR responsible Result secretion serum supernatant TNFα Viral load virus [DOI] 10.1186/s12917-017-1019-2 PMC 바로가기 [Article Type] Research Article
Chemical-controlled Activation of Antiviral Myxovirus Resistance Protein 1Article Published on 2017-02-102023-06-23 Journal: The Journal of Biological Chemistry [Category] 신종인플루엔자, [키워드] antiviral agent GTPase influenza A Influenza virus inhibition mechanism Interaction Molecular biology MX1 negative-strand RNA virus ribonucleoprotein viral replication Virology [DOI] 10.1074/jbc.M116.748806 PMC 바로가기
Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB SignalingArticle Published on 2015-12-172022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] activity Alpha Analysis Antiviral antiviral response Cell cells coronavirus Degradation dehydrogenase DNA binding downregulated enterovirus examined Exogenous expression G6PD glucose-6-phosphate dehydrogenase GTPase HCoV-229E HSCARG human coronavirus 229E IDH1 increased expression Infection inhibited IκB mechanism MX1 NADPH Necrosis NF-κB NF-κB signaling nicotinamide adenine dinucleotide overexpression phosphate promoter Protein reduced response resulting sensor siRNA suppressed susceptibility susceptible TNF- α upregulated viral gene expression viral infection virus infection [DOI] 10.3390/v7122966 PMC 바로가기 [Article Type] Article