MX1 – Communicable Diseases Research

MxA for differentiating viral and bacterial infections in adults: a prospective, exploratory study

article

Published on 2023-02-032024-09-05
Journal: Infection [Category] update2024,

Pin-Pointing the Key Hubs in the IFN-γ Pathway Responding to SARS-CoV-2 Infection

Article

Published on 2022-09-302022-11-16
Journal: Viruses [Category] SARS, 치료법,

Bioinformatics analysis of potential common pathogenic mechanisms for COVID-19 infection and primary Sjogren’s syndrome

COVID-19 감염 및 원발성 쇼그렌 증후군에 대한 잠재적인 일반적인 병원성 메커니즘의 생물정보학 분석

Article

Published on 2022-07-262022-09-11
Journal: Frontiers in Immunology [Category] 유전자 메커니즘,

[키워드] Analysis CDCA2 cellular component cellular components CMPK2 COVID-19 COVID-19 infection cytoHubba database DEGs diagnostic Diagnostic markers differentially expressed differentially expressed gene Differentially expressed genes downloaded Evidence functional annotation Gene Expression Omnibus gene expression profile Gene expression profiles gene regulatory network General population Genes GEO HERC5 hub genes Ifi44 IFI44L IFIT1 IFIT2 IFIT3 marker mechanism metabolic pathway metabolic pathways molecular mechanism molecular mechanisms MX1 participated Pathogenesis pathogenic mechanism pathway Patient performed PPI Prevalence primary Sjogren’s syndrome. progression protein-protein interaction regulatory network reveal RRM2 selected significantly higher Sjögren’s syndrome subsequent analyses syndrome TOP2A transcription factor TYMS
[DOI] 10.3389/fimmu.2022.938837 PMC 바로가기 [Article Type] Article

mRNA-1273 vaccination protects against SARS-CoV-2-elicited lung inflammation in nonhuman primates

mRNA-1273 백신 접종은 비인간 영장류에서 SARS-CoV-2 유발 폐 염증으로부터 보호합니다

Article

Published on 2022-07-082022-09-11
Journal: JCI Insight [Category] COVID19(2023년), SARS, 변종,

[키워드] 48 hour 48 hours Antibody Response Antibody responses Antibody titer Bronchoalveolar lavage fluid CCL3 cellular Cellular immune response chemokines collected correlated COVID-19 CXCL10 dissemination dose-dependent manner expression Genes Human IFIT1 immune immunology independent induction Inflammation Inflammatory ISG15 less limit Lower respiratory tract lung Lung inflammation mRNA mRNA-1273 MX1 observation Pathogenesis profile PROTECT replicated respiratory tract restrict viral replication rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 antibody response SARS-CoV-2 antibody responses SARS-CoV-2 spike SARS-CoV-2 strain serum Support suppressed These data transcriptomic USA-WA1/2020 vaccination Vaccine-induced immunity variant of SARS-CoV-2 viral infection viral replication Viral RNA
[DOI] 10.1172/jci.insight.160039 PMC 바로가기 [Article Type] Article

Transcriptional Profiling and Machine Learning Unveil a Concordant Biosignature of Type I Interferon-Inducible Host Response Across Nasal Swab and Pulmonary Tissue for COVID-19 Diagnosis

전사 프로파일링 및 기계 학습, COVID-19 진단을 위한 비강 면봉 및 폐 조직 전반에 걸쳐 I형 인터페론 유도성 숙주 반응의 일치하는 생체특징 공개

Immunology

Published on 2021-11-222022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술,

[키워드] adjusted adopted Analysis approach biosignature BST2 caused complementary computational analysis concordant conserved COVID-19 COVID-19 diagnosis data interpretation dataset Diagnosis Diagnostic method embedding Factor false-negative Genes geometric global pandemic GSE147507 heterogeneous high mortality homological Host host response IFIT1 IFIT2 IFIT3 IFITM1 IFN-I IFN-I signaling infection control Interferome interferon involved ISG15 Limited lung tissue machine learning morbidity MX1 MX2 nasal swab NCBI-GEO network OAS1 OAS2 OAS3 OASL objective other respiratory infections outcome Profiling pulmonary respiratory respiratory infections response Result retrieved RNA-seq data RNA-sequencing RSAD2 RT-PCR SARS-CoV-2 SARS-CoV-2 virus sequencing data severity of COVID-19 similarity Stat1 stochastic stratified transcriptional transcriptional level transcriptomics Type type I interferon virus was used WGCNA
[DOI] 10.3389/fimmu.2021.733171 PMC 바로가기 [Article Type] Immunology

Proteomic Signature of Host Response to SARS-CoV-2 Infection in the Nasopharynx

비인두에서 SARS-CoV-2 감염에 대한 숙주 반응의 단백질 서명

Research

Published on 2021-08-142022-09-10
Journal: Molecular & Cellular Proteomics : MCP [Category] 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition AGC, automatic gain control airway AKT Analysis antiviral property antiviral signaling asymptomatic infection caused CEP131 CFAP57 characterized ciliary component components confirmed COVID-19 case controls coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 COVID-19 severity COVID-19, Coronavirus disease 2019 CXCL10 downregulation dysregulated immune response dysregulation E3 ubiquitin ligases FDR, false discovery rate Health High-resolution host response humans IFN, interferon immune response implicated infected individual infected individuals Infection Inflammatory response interferon interferon-stimulated gene interferon-stimulated genes investigator investigators involved ISG15 ISGs, interferon-stimulated genes mechanism MERS-CoV, Middle East respiratory syndrome coronavirus molecular MPB, mobile phase B multiorgan disease MX1 nasopharyngeal swabs negative control negative controls NHBE, normal human bronchial epithelial novel NP, nasopharyngeal OGFR, opioid growth factor receptor OPRPN, Opiorphin prepropeptide pandemic Pathogenesis pathogenesis of COVID-19 Pathways performed phosphoproteome Phosphoproteomics Phosphorylation PKC PPIase, peptidyl-prolyl cis/trans isomerase PRM, parallel reaction monitoring proteasomal Protein protein synthesis proteomic Proteomic analysis proteomics PRRs, pathogen-recognition receptors respiratory response RIG-I SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome Coronavirus shown signaling pathway signature Stat1 subunits Swab These data upper airway upregulated upregulation valuable resource Viral viral entry viral infection viral infections virus
[DOI] 10.1016/j.mcpro.2021.100134 PMC 바로가기 [Article Type] Research

SARS-CoV-2 Infection Remodels the Phenotype and Promotes Angiogenesis of Primary Human Lung Endothelial Cells

Article

Published on 2021-07-032022-10-29
Journal: Microorganisms [Category] COVID-19,

[키워드] absence ACE2 expression acute lung injury acute respiratory distress analyses Analysis Angiogenesis angiogenic response antiviral molecule ARDS conditioned COVID-19 Cytopathic effect detectable early phase Endothelial cell endothelial cell dysfunction expression Human Hypothesis identify immunofluorescence assay infect Infection Inflammation Inflammatory inhibit integrin Intussusceptive angiogenesis life-threatening lung manifestation Microarray microenvironment MX1 Particles pathogenic mechanism phenotype plethora potential therapeutic target pro-inflammatory proteome Respiratory complications SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection stimulated Support syndrome vascular dysfunction vascular leakage viral infection
[DOI] 10.3390/microorganisms9071438 PMC 바로가기 [Article Type] Article

High rate of HSV-1 reactivation in invasively ventilated COVID-19 patients: Immunological findings

침습적으로 환기 된 COVID-19 환자에서의 높은 HSV-1 재 활성화율 : 면역 학적 소견

Research Article

Published on 2021-07-012022-09-10
Journal: PLoS ONE [Category] MERS, SARS, 치료기술,

[키워드] activated acute respiratory distress acute respiratory distress syndrome analyzed Antiviral Beta CD38 CD8 T cell CD8 T cells Cohort Comprehensive Course COVID-19 COVID-19 patient decreased expression drop evaluated FACS analysis Factor Frequency functional Gene expression analysis HLADR HSV-1 IFI44L IFIT1 IL-1 Infection interferon interferon-stimulated genes invasive ventilation invasively ventilated patient invasively ventilated patients later phase lead MX1 occur patients PCR performed Peripheral blood Phase 1 Phase 2 predisposing factors pulmonary Quantitative Reactivation respiratory respiratory distress respiratory specimen respiratory specimens RSAD2 SARS-CoV-2 SARS-COV-2 infection screened secretion severe acute respiratory distress syndrome severe pneumonia shown significant increase significantly lower symptom onset syndrome T cells time Ventilated Whole blood
[DOI] 10.1371/journal.pone.0254129 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 ORF8 Forms Intracellular Aggregates and Inhibits IFNγ-Induced Antiviral Gene Expression in Human Lung Epithelial Cells

Immunology

Published on 2021-06-092022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome addition aggregate aggregation analyses Anti-viral Antiviral antiviral immunity antiviral molecule antiviral molecules association baseline bioinformatic analysis cause cell cycle progression cell proliferation cellular cellular distribution cellular processes characteristic coronavirus COVID-19 COVID-19 patient Culture cytosol DHX58 disease ectopic expression Effect epithelial examined expressed expressing expression facilitate form Frame Host Human human lung IFNβ IFNγ Immunofluorescent staining in silico independent Inflammation inhibit innate immune response interferon signaling Intracellular intrinsic lung lung epithelial lung epithelial cell Lung epithelial cells Lung injury lung tissue MX1 MX2 N-terminal not affect nuclear ORF8 pathogenic Protein Regulation residue SARS-CoV-2 SARS-CoV-2 accessory protein SARS-COV-2 infection suppressed Symptom unique viral infection ZBP1
[DOI] 10.3389/fimmu.2021.679482 PMC 바로가기 [Article Type] Immunology

Interferon antagonism by SARS-CoV-2: a functional study using reverse genetics

SARS-CoV-2에 의한 인터페론 길항작용: 역유전학을 이용한 기능적 연구

Article

Published on 2021-05-012022-09-11
Journal: The Lancet. Microbe [Category] Fulltext, SARS, 변종, 치료제,

[키워드] Activation acute respiratory syndrome adaptive Amino acid amino acid substitution amino acid substitutions amino acids analysed Analysis antagonistic backbone Bildung Calu Calu-3 cell calu-3 cells camostat camostat mesilate Cell cell entry cell line cellular entry receptor changes COVID-19 cytokine domain ENCODE Epidemic evaluate evaluated expressed fitness Frame functional gene induction Genes Genetic genetic engineering genetics homologous homology host cell host cells interfere interferon interferon antagonism interferon treatment interferon-stimulated gene interferon-stimulated genes investigated IRF3 less luciferase Mutagenesis mutant MX1 nuclear translocation Open reading frame ORF6 phenotype phenotypic Protein Replication residue residues RT-PCR SARS-CoV SARS-CoV-2 SARS-CoV-2 protein sensitivity Severe acute respiratory syndrome strain Strains suppressed TMPRSS2 transcription factor transmission efficiency Treatment type I interferon Vero E6 Vero E6 cell VERO E6 cells virus wild-type
[DOI] 10.1016/S2666-5247(21)00027-6 PMC 바로가기 [Article Type] Article