Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to TreatmentReview Published on 2021-01-142022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] Cannabis Bioavailability cannabis Clinical use Compound coronavirus disease Diseases drug epilepsy expressed G protein-coupled receptor glycine group implication include Inflammatory bowel disease knowledge meeting multiplex multitarget natural nausea Pain Parkinson’s disease penetration pharmacological phytocannabinoids (THC and CBD) provide receptor receptors Schizophrenia selected Serotonin structures syndrome synergism synergistic terpenes these compound Treatment TRP vomiting [DOI] 10.3390/ijms22020778 PMC 바로가기 [Article Type] Review
Examining the effector mechanisms of Xuebijing injection on COVID-19 based on network pharmacologyResearch Published on 2020-10-162022-10-28 Journal: BioData Mining [Category] COVID-19, [키워드] activated Activation Active ingredient ALB albumin Analysis Anti-inflammatory AutoDock B cell binding activity biological process BPS cascade CASP3 cellular response Chinese component Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease Cytoscape Cytoscape software database demonstrated disease docking score Effect effective Effector mechanism Effects EGFR endothelial enrichment analysis epidermal ESR1 estrogen receptor Examining explain Extracellular GAPDH GeneCard Genes growth factor IL-2 Inflammation ingredient injection International JUN KEGG Kyoto less MAPK MAPK1 MAPK14 MAPK8 mechanism Mild molecular docking Necrosis network pharmacology NF-κB nuclear Ontology participated Pathways pharmacological mechanism PI3K potential mechanism potential therapeutic target PPI predict produced Protein protein-protein interaction provided PTGS2 RAS receptor regulated Regulation renin-angiotensin system Result searched Sepsis severe pneumonia signaling pathway STAT3 SwissTargetPrediction database synergistic T-cell receptor target targets therapeutic effect TLR TNF Toll-like receptor Topology Transcription Treatment TRP VEGF was used Xuebijing [DOI] 10.1186/s13040-020-00227-6 PMC 바로가기 [Article Type] Research
TRPV4: A Physio and Pathophysiologically Significant Ion ChannelReview Published on 2020-05-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] animal model channel clinical trial Consequences disease dysfunction Evidence highlight Human invertebrate Ion pathophysiological physiological Potential Protein receive Significant Structure therapeutic target Transient TRP TRP channels TRPV1 TRPV4 variety vertebrates [DOI] 10.3390/ijms21113837 PMC 바로가기 [Article Type] Review
Lifting the veil on the keratinocyte contribution to cutaneous nociceptionReview Published on 2020-01-062024-09-02 Journal: Protein & Cell [Category] 대상포진, [키워드] Inflammation keratinocyte nociception Pain skin TRP [DOI] 10.1007/s13238-019-00683-9 PMC 바로가기 [Article Type] Review
Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte DysfunctionImmunology Published on 2019-10-292022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, [키워드] Cacna1f Activation Apoptosis B lymphocyte CaV1.4 calcium Cell channel chronic B cell activation chronic infections controls CRAC dysfunction effector memory elevated environmental condition event exacerbated example exhibited hallmark homeostasis Immune phenotype immune system immunological inhibitory receptor Inhibitory Receptors L-type L-type calcium channel marker maturation mice murine gammaherpesvirus 68 Mutation physiological reduced secondary messenger Signaling sustained T cell T cell exhaustion T cell memory T lymphocyte T lymphocytes TRP upregulation virus infection wild-type [DOI] 10.3389/fimmu.2019.02473 PMC 바로가기 [Article Type] Immunology