Proliferation of SARS-CoV-2 B.1.1.7 Variant in Pakistan-A Short Surveillance AccountSARS-CoV-2 B.1.1.7 파키스탄-A 단기 감시 계정의 변종 확산Public Health Published on 2021-05-312022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 변종, 치료기술, 치료제, [키워드] A570D affecting amplification B.1.1.7 B.1.1.7 variant B1.1.7 characteristic circulation country COVID-19 diagnostics followed by Frequency Genome genomic implementation implication increase in initial screening Laboratory low frequency measure Mutation N501Y ORF P681H Pakistan public health raised reported RT-PCR kit SARS-CoV-2 SARS-CoV-2 B.1.1.7 Sequencing spike gene subset Surveillance T716I TaqPath tested the Spike ThermoFisher Scientific United Kingdom upsurge variant of SARS-CoV-2 virus transmissibility VoC whole-genome sequencing [DOI] 10.3389/fpubh.2021.683378 PMC 바로가기 [Article Type] Public Health
Mutations in the B.1.1.7 SARS-CoV-2 Spike Protein Reduce Receptor-Binding Affinity and Induce a Flexible Link to the Fusion PeptideArticle Published on 2021-05-082022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] A570D ACE2 ACE2 binding Affect affected affinity Analysis B.1.1.7 B.1.1.7 variant binding affinity biochemical Cell consequence Contact COVID-19 D614G D614G mutation fusion fusion peptide Interaction interface region linear molecular Molecular dynamics simulation Mutation N501Y N501Y mutation Patient RBD Receptor binding reduced Salt Bridge SARS-CoV-2 significantly spike Spike protein stability starting point structural flexibility The B.1.1.7 the RBD the receptor-binding domain the SARS-CoV-2 the SARS-CoV-2 virus the spike protein trimer variant virus wild type [DOI] 10.3390/biomedicines9050525 PMC 바로가기 [Article Type] Article
Structural Consequences of Variation in SARS-CoV-2 B.1.1.7Article Published on 2021-04-252022-10-30 Journal: Journal of cellular immunology [Category] COVID-19, [키워드] A570D ACE2 Alter Angiotensin converting enzyme-2 asked B.1.1.7 binding Characteristics circulating cleavage consequence Contact D614G D614G mutation Drug discovery Effects evaluated Evolution faster fixed functional high affinity host cell immune evasion immune response intermolecular interactions involved mechanisms mutated Mutation N501Y New Protein reduced Replication S1 and S2 S982A SARS-CoV-2 SARS-CoV-2 B.1.1.7 SARS-CoV-2 strain spike glycoprotein Structural analysis subunit subunits the spike protein thought Transmissibility trimer trimeric spike UK variant B.1.1.7 unique United Kingdom variant variant spike virus Virus life cycle virus transmissibility Wuhan Wuhan-Hu-1 Wuhan-Hu-1 spike protein [DOI] 10.33696/immunology.3.085 PMC 바로가기 [Article Type] Article
A model for pH coupling of the SARS-CoV-2 spike protein open/closed equilibriumCase Study Published on 2021-03-252022-10-28 Journal: Briefings in Bioinformatics [Category] COVID-19, SARS, [키워드] A570D acute respiratory syndrome Affect binding calculated Cell complement contribute coronavirus coronavirus disease Coronaviruses COVID-19 D614G mutation dependent on ectodomain Effect elevated Endosomes feature form heat map histidine human coronaviruses include Interaction interactions moderate modulate Mutagenesis Mutation observation Other other coronaviruses pandemic pH-dependence pre-fusion predicted Proteases protein electrostatics receptors residue RNA genome salt-bridge SARS-CoV-2 SARS-COV-2 infection Spike protein spike trimer stability Structure structures suggested the SARS-CoV-2 thought trimer virus entry [DOI] 10.1093/bib/bbab056 PMC 바로가기 [Article Type] Case Study