Omicron Variant of SARS-CoV-2 Virus: In Silico Evaluation of the Possible Impact on People Affected by Diabetes MellitusSARS-CoV-2 바이러스의 오미크론 변종: 당뇨병의 영향을 받는 사람들에게 미칠 수 있는 영향에 대한 실리코 평가Article Published on 2022-03-072022-09-11 Journal: Frontiers in Endocrinology [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE-2 receptor ACE2 ACE2 receptor affected Analysis approach asparagine B.1.1.529 binding cause Cell Characteristics computational analysis COVID-19 COVID-19 disease demonstration diabete diabetes Diabetes Mellitus entry routes evidenced feature finding Glycation higher affinity human ACE2 receptor human ACE2 receptor. Impact in silico Interaction interactivity lysine Maillard reaction maintain mechanism molecular Molecular mechanics mutant mutate Mutation omicron Omicron variant outcome Pathways RBD Receptor-binding domain residue risk SARS-CoV-2 severity shift shifting spike Spike protein surface area the disease the receptor-binding domain variant variant of SARS-CoV-2 virus virus attack wild-type [DOI] 10.3389/fendo.2022.847993 PMC 바로가기 [Article Type] Article
Investigation of the Role of Healthy and Sick Equids in the COVID-19 Pandemic through Serological and Molecular TestingArticle Published on 2022-02-282022-10-28 Journal: Animals : an Open Access Journal from MDPI [Category] COVID-19, [키워드] ACE-2 receptor antibody Blood clinical disease close contact Cohort collected COVID-19 detectable determine develop diagnostic ELISA equine feature Fever healthy healthy horses hematological homology horses Host Human IgG antibody infected with SARS-CoV-2 Influenza virus investigation Laboratory molecular nasal nasal secretions onset of fever qPCR reported respiratory pathogen Respiratory pathogens role SARS-CoV-2 SARS-COV-2 infection secretion serological serum sample sick equids silent infection simple Streptococcus subclinical infection submitted susceptible Swab tested Testing the receptor-binding domain the spike protein Thoroughbred transmission of SARS-CoV-2 virus while with COVID-19 [DOI] 10.3390/ani12050614 PMC 바로가기 [Article Type] Article
Elevated Cytokine Levels in Plasma of Patients with SARS-CoV-2 Do Not Contribute to Pulmonary Microvascular Endothelial PermeabilitySARS-CoV-2 환자의 혈장에서 증가된 사이토카인 수준은 폐 미세혈관 내피 투과성에 기여하지 않습니다Research Article Published on 2022-02-162022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, [키워드] accounted ACE-2 receptor ACE2 antibody acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute SARS-CoV-2 infection angiopoietin antagonists antiinflammatory cytokines appear approach ARDS barrier dysfunction C3a C5a cause Cell changes in circulating Combination complement complements factors consecutive patient Control controls coronavirus cytokine Cytokines death demonstrated determine disrupt Effect eight Elevation endothelial Endothelial cell endothelial injury endothelial permeability enrolled evaluated Evidence evidence of Frequency greater growth factor heat inactivation human lung in vitro infections inhibitors labile Level lung magnitude mechanism Microvascular damage morbidity morbidity and mortality multiorgan failure Neutralizing antibodies neutralizing antibody occur patients patients hospitalized patients with SARS-CoV-2 permeability plasma positive control predicted produced proinflammatory cytokines provide pulmonary receptor receptor antagonists respiratory respiratory distress SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2 plasma selected severe acute respiratory syndrome Coronavirus severe complication severe complications Spike protein subsequent susceptible syndrome the SARS-CoV-2 thrombin TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha Variability Vascular vascular endothelial growth factor Vascular injury vascular permeability VEGF [DOI] 10.1128/spectrum.01671-21 PMC 바로가기 [Article Type] Research Article
Structural modeling of Omicron spike protein and its complex with human ACE-2 receptor: Molecular basis for high transmissibility of the virusOmicron 스파이크 단백질 및 인간 ACE-2 수용체와의 복합체 구조 모델링: 바이러스의 높은 전염성을 위한 분자 기반Article Published on 2022-02-122022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 변종, [키워드] ACE-2 ACE-2 receptor analysed Analysis binding complex domain eight explain glycoprotein Human Human ACE-2 receptor hydrogen Hydrogen bond infecting Infection Interaction interactions interface intra-molecular ionic interactions mutant Mutation mutations omicron Omicron variant parameter Pathogenesis Protein RBD RBD domain receptor Receptor binding domain residue Result Salt Bridge Seven simulation studies spike spike glycoprotein Spike protein Structural analysis Transmissibility trimeric Van variant of SARS-CoV-2 virus wild type [DOI] 10.1016/j.bbrc.2021.12.082 PMC 바로가기 [Article Type] Article
Mutations in human SARS-CoV-2 spike proteins, potential drug binding and epitope sites for COVID-19 therapeutics developmentResearch article Published on 2022-02-092022-10-05 Journal: Current Research in Structural Biology [Category] 변종, [키워드] ACE-2 receptor amino acid residue amino acid residues amino acid substitution analysed assigned binding complex COVID-19 pandemic COVID-19 therapeutics develop disease Drug design sites epitope Epitope sites human SARS-CoV-2 Human SARS-CoV-2 mutations Interaction Invariant sites monoclonal antibodies mutated Mutation Mutation propensity occur outbreak PDB Protein Protein Data Bank protein sequence Receptor binding domain remained reported residue SARS-CoV-2 spike protein sequence Seven Spike protein Spike protein sequence Spike proteins target the SARS-CoV-2 the spike protein variant variants VoC Wuhan-Hu-1 [DOI] 10.1016/j.crstbi.2022.01.002 [Article Type] Research article
The human ACE-2 receptor binding domain of SARS-CoV-2 express on the viral surface of the Newcastle disease virus as a non-replicating viral vector vaccine candidateSARS-CoV-2의 인간 ACE-2 수용체 결합 도메인은 비복제 바이러스 벡터 백신 후보로서 뉴캐슬병 바이러스의 바이러스 표면에서 발현Research Article Published on 2022-02-082022-09-12 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE-2 receptor addition alum Antibody titer binding domain caused Concentration COVID-19 vaccine death demonstrated elect Express expressed Health health problem Human inactivated Infection inoculated mice neutralization Neutralizing antibodies neutralizing antibody newcastle disease virus optical density pandemic disease protective immunity pseudovirus RBD RBD protein Receptor-binding domain sandwich ELISA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus sera Spread TCID the receptor-binding domain the SARS-CoV-2 viral surface Viral vector vaccine virus were measured [DOI] 10.1371/journal.pone.0263684 PMC 바로가기 [Article Type] Research Article
SARS-COV-2 Variants: Differences and Potential of Immune EvasionSARS-COV-2 변종: 면역 회피의 차이점과 가능성Review Published on 2022-01-182022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 진단, [키워드] ACE-2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addressed B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Brazil Characteristics concerning Coronavirus-2 COVID-19 COVID-19 pandemic Critical critical points delta variant difference disease severity generate glycoprotein immune Immune escape IMPROVE include India Infection Mutation Neutralizing antibodies neutralizing antibody Omicron variant P.1 pandemic Perspective Potential potential risk reducing Reinfection resistance to neutralizing antibodies respiratory risk S gene SARS-CoV-2 selective Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 South Africa survival the SARS-CoV-2 Transmissibility vaccination Vaccines variant variant of concern variants variants of concern Viral viral fitness viral replication VoC VOCs [DOI] 10.3389/fcimb.2021.781429 PMC 바로가기 [Article Type] Review
Liver Injury in Patients with COVID-19 without Underlying Liver DiseaseArticle Published on 2022-01-082022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE-2 receptor Analysis cholestasis Clinical course Course COVID-19 COVID-19 in patient death epithelial cell excluded hepatocellular high affinity higher risk Hospitalization Injury intestine involved kidneys Laboratory less Liver disease Liver function test Liver injury Lower respiratory tract material mechanism Mild Mortality parenchymal Patient patients patients died patients with COVID-19 presenting resolved returned SARS-CoV-2 SARS-COV-2 infection SIGN Symptom Treatment vascular endothelial cells with COVID-19 [DOI] 10.3390/jcm11020308 PMC 바로가기 [Article Type] Article
Mutational landscape of SARS-CoV-2 genome in Turkey and impact of mutations on spike protein structureResearch Article Published on 2021-12-062022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] accumulation ACE-2 receptor Algorithms analyzed applied approach Asia B.1 B.1.1 B.1.1.7 binding domain clade Concordance COVID-19 detect determine distribution distributions Effect Europe evaluated exhibit genome sequence genomic GISAID database help hydrophilicity Impact in silico increase in introduced lab less Mutation mutations pandemic Patient Protein SARS-CoV-2 genome SARS-CoV-2 genome sequence Spike protein submitted the SARS-CoV-2 genome the spike protein timeline Treatment strategies Turkey USA vaccination variant variations WHO World Health Organization [DOI] 10.1371/journal.pone.0260438 PMC 바로가기 [Article Type] Research Article
Potential pharmacologic treatments for COVID-19 smell and taste loss: A comprehensive reviewReview article Published on 2021-12-012022-10-05 Journal: European journal of pharmacology [Category] SARS, 임상, 치료법, [키워드] ACE-2 receptor Affect Ageusia Anosmia Anti-inflammatory benefit Cell clinical trial Corticosteroid COVID-19 COVID-19 patient depolarizing Evidence expressed Gustatory hallmark information inhibitors insulin Interaction Invasion local inflammation loss of taste management mechanisms Novel coronavirus olfactory olfactory neuron pathologic pathophysiology pathway patients pharmacologic treatment Potential Potential treatment provided searched Symptom Therapeutics Treatment virus [DOI] 10.1016/j.ejphar.2021.174582 [Article Type] Review article