ACE1 – Page 2 – Communicable Diseases Research

The Role of Angiotensin Converting Enzyme 1 Insertion/Deletion Genetic Polymorphism in the Risk and Severity of COVID-19 Infection

Medicine

Published on 2021-12-232022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Angiotensin–Converting Enzyme (ACE) 1 Gene Polymorphism and Phenotypic Expression of COVID-19 Symptoms

안지오텐신-전환 효소(ACE) 1 유전자 다형성 및 COVID-19 증상의 표현형 발현

Review

Published on 2021-10-012022-09-10
Journal: Genes [Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] ACE1 I/D polymorphism ACE ACE1 ACE1 gene ACE2 Affect aldosterone Alu angiotensin appear article Asia association biochemical candidate Candidates Clinical outcome Comorbidities component concert conducted country COVID-19 COVID-19 symptoms diagnosis of SARS-CoV-2 East evaluate Evidence explain expression Frequency Genes Genotype group homolog Hypothesis I/D polymorphism Infection infections influence insertion Interaction involved mechanisms Medline database Mortality MOST numbers of patient opposite organ Pathogenesis pathogenesis of COVID-19 pathophysiology phenotypic Phenotypic Expression polymorphism Polymorphisms pulmonary disease RAAS reported Research risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections searched selected severity subgroups subgroups of patients Support Treatment West
[DOI] 10.3390/genes12101572 PMC 바로가기 [Article Type] Review

In-hospital use of ACE inhibitors/angiotensin receptor blockers associates with COVID-19 outcomes in African American patients

아프리카계 미국인 환자의 COVID-19 결과와 관련된 ACE 억제제/안지오텐신 수용체 차단제의 병원 내 사용

Clinical Trial

Published on 2021-10-012022-09-11
Journal: The Journal of Clinical Investigation [Category] SARS, 유전자 메커니즘, 임상,

[키워드] 95% CI ACE ACE inhibitors ACE1 African American African Americans allele angiotensin Angiotensin receptor blockers Angiotensin-converting enzyme ARB association blocker cardiovascular cardiovascular disease coronavirus disease Coronavirus disease 2019 COVID-19 drug drug therapy Epidemiology evaluated hospital improved mortality In-hospital in-hospital mortality mechanism medication Mortality Mount Sinai multivariate logistic regression multivariate logistic regression model New York City outcome Pathogenesis Patient patients with COVID-19 prevalent receptor reduced reduced risk reduction in severe coronavirus disease significantly tested with COVID-19
[DOI] 10.1172/JCI151418 PMC 바로가기 [Article Type] Clinical Trial

Pan-Cancer Analysis of Genomic and Prognostic Characteristics Associated With Coronavirus Disease 2019 Regulators

Medicine

Published on 2021-08-112022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] ACE1 ACE2 AGT Analysis analyzed Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach Atla Biomarkers Cancer cancers Clinical characteristics coronavirus disease correlated COVID-19 COVID-19 regulators database drug drugs targeting evaluated expression level genetic alteration genetic alterations genomic alteration information Interaction mechanism Methylation outcomes Pan-cancer Pathways Patient portal potential mechanism Prognosis prognostic receptor regulator response RNA-seq data sensitivity serine protease significantly single nucleotide SLC6A19 solid tumor solid tumors Therapeutics TMPRSS2 tumorigenesis Variation widespread
[DOI] 10.3389/fmed.2021.662460 PMC 바로가기 [Article Type] Medicine

Age-Related Differences in the Expression of Most Relevant Mediators of SARS-CoV-2 Infection in Human Respiratory and Gastrointestinal Tract

Pediatrics

Published on 2021-07-282022-10-31
Journal: Frontiers in Pediatrics [Category] COVID-19,

[키워드] ACE1 ACE2 ACE2 expression acute respiratory syndrome adult subject adult subjects Adults Analysis Angiotensin-converting enzyme angiotensin-converting enzyme 2 children clinical clinical feature Clinical severity coronavirus coronavirus disease COVID-19 difference differential expression evaluated expression feature functional Gastrointestinal healthy subjects Host Human Infection Interaction intestinal investigated mediator MOST nasal nasal epithelium Neuropilin-1 no difference NRP1 preventive measure promote quantitative real-time PCR receptor respiratory SARS-CoV-2 SARS-COV-2 infection Serine severity small intestine Symptom the SARS-CoV-2 These data TMPRSS2 TMPRSS2 expression tract transmembrane transmembrane serine protease-2 Treatment upper respiratory tract virus
[DOI] 10.3389/fped.2021.697390 PMC 바로가기 [Article Type] Pediatrics

Impact of I/D polymorphism of angiotensin-converting enzyme 1 (ACE1) gene on the severity of COVID-19 patients

코로나19 환자의 중증도에 대한 ACE1(지오텐신 전환 효소 1) 유전자의 I/D 다형성의 영향

Article

Published on 2021-07-012022-09-11
Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, 진단, 치료기술,

[키워드] ACE ACE I/D polymorphism ACE1 ACE2 ACE2 receptor acute respiratory disease acute respiratory syndrome ADRS allele angiotensin angiotensin I Angiotensin II Angiotensin-converting enzyme association Asymptomatic binding cause Chain Reaction China Clinical outcome Corona virus coronavirus COVID-19 COVID-19 patient detect diabete diabetes disease etiology facilitate followed by Frequency Genotype genotyped host cell hypertension I/D I/D polymorphism Imbalance Impact incidence Interaction Lung injury marker Older age Pathogenesis Patient polymerase chain polymerase chain reaction Predictive researcher respiratory risk RT-PCR SARS-CoV-2 SARS-CoV2 Severe acute respiratory syndrome Severe acute respiratory syndrome corona virus-2 severe COVID-19 severe lung injury severity severity of COVID-19 significantly significantly higher SPSS statistical analysis susceptibility syndrome These data Version
[DOI] 10.1016/j.meegid.2021.104801 PMC 바로가기 [Article Type] Article

In silico Nigellidine (N. sativa) bind to viral spike/active-sites of ACE1/2, AT1/2 to prevent COVID-19 induced vaso-tumult/vascular-damage/comorbidity

인실리코 니겔리딘(N. sativa)은 ACE1/2, AT1/2의 바이러스 스파이크/활성 부위에 결합하여 COVID-19 유발 혈관 손상/혈관 손상/동반 질환을 예방합니다

Article

Published on 2021-06-012022-08-31
Journal: Vascular pharmacology [Category] MERS, SARS, 신약개발, 진단, 치료제,

Does Genetic Predisposition Contribute to the Exacerbation of COVID-19 Symptoms in Individuals with Comorbidities and Explain the Huge Mortality Disparity between the East and the West?

유전적 소인은 동반 질환이 있는 개인의 COVID-19 증상 악화에 기여하고 동양과 서양의 엄청난 사망률 격차를 설명합니까?

Review

Published on 2021-05-082022-09-10
Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘,

[키워드] ACE1 DD genotype AAT deficiency ACE1 ACE1/ACE2 ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADAM17 aggravation aldosterone allele alveolar Ang II angiotensin Angiotensin-converting enzyme association best cardiovascular disease carrier chronic inflammation Chronic kidney disease Combination Comorbidities Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death deficiency diabetes discrepancy disparity East Exacerbation example expected explain Factor Genes Genetic Genetic predisposition Genotype greater healthy hypertension Hypothesis increase individual Inflammation Inflammatory mediators intron involved Kidney disease lack marker mediators) Medical conditions Mild obesity Patient Pneumonia polymorphism Polymorphisms potential mechanism potential mechanisms RAAS respiratory risk SARS-CoV-2 SARS-COV-2 infection searched severe acute respiratory syndrome Coronavirus Severe case severe cases severity subtype Viral viral infection
[DOI] 10.3390/ijms22095000 PMC 바로가기 [Article Type] Review

Repurposing of approved drugs with potential to interact with SARS-CoV-2 receptor

Research Article

Published on 2021-03-292022-10-04
Journal: Biochemistry and Biophysics Reports [Category] 신약개발,

[키워드] Abstract ACE ACE1 ACE2 addition Amino acid Analysis angiotensin approved drug binding Cell comparable coronavirus 2 COVID-19 distribution domain Drug repurposing entry of SARS-CoV-2 enzyme epithelial expression homolog host cells host-virus interaction human cells human lung Image Infection Interaction interfere low expression organized peptidase predict primary sequence Proteins RBD receptor Receptor binding domain Region reported repurposing respiratory S protein same order SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 spike protein similarities similarity spike glycoprotein Spike protein the SARS-CoV-2 tissue Transmission variety viral spike protein X-ray crystallographic structure
[DOI] 10.1016/j.bbrep.2021.100982 PMC 바로가기 [Article Type] Research Article

Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus

서아프리카 Anopheles의 pirimiphos-methyl에 대한 내성은 Ace1 유전자좌의 복제 및 유전자이입을 통해 확산되고 있습니다.

Research Article

Published on 2021-01-212022-09-06
Journal: PLoS Genetics [Category] Communicable Disease, 말라리아,

[키워드] ACE1 acetylcholinesterase African Analysis Anophele Anopheles gambiae approach association Carbamate Combination complex Control copy number diagnostic dominant driven by duplication duplications effective Effectiveness enzyme Genetic genomes genomic Haplotype highlight increasingly insecticidal insecticide insecticides Intervention locus malaria malaria vector molecular Mutation Non-synonymous occur organophosphate overcome phenotypic pirimiphos-methyl Population populations Predictive Predictive value predictor Prevent provide public health reduce Replication resistance resistance mechanism resistance mechanisms selection pressure sequenced specimen Spread sub-Saharan Africa Surveillance transferred Transmission unique Variation vector vectors West whole genome
[DOI] 10.1371/journal.pgen.1009253 PMC 바로가기 [Article Type] Research Article