Angiotensin-converting enzyme 1 and voltage-gated potassium channel-interacting protein 4 gene polymorphisms in COVID-19 patients from east of IranArticle Published on 2022-11-012022-11-15 Journal: Clinica chimica acta; international journal of cli [Category] 진단, [키워드] ACE1 acute respiratory syndrome affecting Angiotensin-converting enzyme Angiotensin-converting enzyme 1 Care case-control study caused coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient COVID-19 susceptibility death disease enzyme Ethnic groups Factor Frequency Genetic Genotype genotyped Health healthy controls I/D polymorphism Infection Iran KCNIP4 material outcome pandemic pathogen PCR polymorphism Polymorphisms populations Potassium Prognostic factor Protein Region Research Respiratory disease severe acute respiratory syndrome coronavirus 2 severity statistically significant supported survival Variation Voltage-gated potassium (Kv) channel-interacting protein 4. [DOI] 10.1016/j.cca.2022.09.006 PMC 바로가기
Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severityReview article Published on 2022-11-012022-10-05 Journal: Gene [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] ACE1 ACE2 AGTR1 ApoE association Case-control CCR5 Clinical outcome contribute contributing to Control correlation country COVID-19 COVID-19 pandemic COVID-19 susceptibility Critical eligible Evidence exacerbated examined Factor Genes Genetic genetic determinant Genetic polymorphism Genetic variant greater Health Healthcare system Host host genetics human gene I/D identify IFITM3 implicated increased risk increasingly infected individual infected individuals Infection investigated magnitude manifestation Manifestations Meta-analysis mutations Patient performed polymorphism progression provide required Research rs2285666 SARS-CoV-2 severe COVID-19 severity Statistical power statistically significant susceptibility systematic review variant with COVID-19 [DOI] 10.1016/j.gene.2022.146790 [Article Type] Review article
Negative correlation between ACE2 gene expression levels and loss of taste in a cohort of COVID-19 hospitalized patients: New clues to long-term cognitive disordersArticle Published on 2022-09-292022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, [키워드] ACE1 ACE2 ACE2 expression ACE2 gene addition Ageusia Alu Analysis Angiotensin-converting enzyme Anosmia association Brain Cell cells cognitive Cognitive dysfunction Cohort consequence correlation COVID-19 disorder Effect evaluated expression expression level Factors gene expression level Genetic genetic association Health Hospitalized hospitalized patients human cell initial symptoms long-COVID long-COVID syndrome Loss of Smell loss of taste molecular nasopharyngeal negative New obligatory occur Olfactory epithelium outcomes penetration polymorphism prevalent priming protease Quantitative quantitative trait receptor Regression model Research Respiratory system RT-qPCR SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Spread Symptom Symptoms tissue TMPRSS2 variable virus [DOI] 10.3389/fcimb.2022.905757 PMC 바로가기
Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: A systematic review and meta-analysisCOVID-19 질병 및 중증도에 대한 감수성과 관련된 유전적 다형성: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-07-062022-09-11 Journal: PLoS ONE [Category] 변종, [키워드] 95% CI ACE1 advanced age allele alleles analyzed ApoE article association C allele calculated candidate gene CCR5 clinical symptom Clinical symptoms Comorbidities contribute COVID-19 COVID-19 disease COVID-19 infection COVID-19 pathogenesis COVID-19 severity disease eligible fixed form forms Genetic polymorphism genetic polymorphisms Genetic variant genetic variants GWAS HLA HLA-A HLA-B HLA-C identify investigated involved loci Meta-analysis polymorphism Polymorphisms presence of comorbidity random Repository risk searched severe forms of COVID-19 severity of COVID-19 significantly Stata software suggested susceptibility systematic review the disease TMPRSS2 Variation [DOI] 10.1371/journal.pone.0270627 PMC 바로가기 [Article Type] Meta-Analysis
Genetic polymorphisms of ACE1, ACE2, and TMPRSS2 associated with COVID-19 severity: A systematic review with meta-analysisReview Published on 2022-07-012023-07-07 Journal: Reviews in Medical Virology [Category] COVID19(2023년), [키워드] ACE1 ACE2 COVID-19 Genetic polymorphism severity susceptibility TMPRSS2 [DOI] 10.1002/rmv.2323 [Article Type] Review
IFNL4, ACE1, PKR, IFNG, MBL2 genetic polymorphisms and severe COVID-19: A protocol for systematic review and meta-analysisIFNL4, ACE1, PKR, IFNG, MBL2 유전적 다형성 및 중증 COVID-19: 체계적인 검토 및 메타 분석을 위한 프로토콜Article Published on 2022-05-272022-09-11 Journal: Medicine [Category] COVID19(2023년), MERS, meta-analysis, SARS, [키워드] ACE-2 ACE1 angiotensin angiotensin-2 converting enzyme association caused Chinese Cochrane Handbook Cochrane Library Corona virus COVID-19 disease Effect English enzyme evaluated Evidence Genetic polymorphism genetic polymorphisms Google Scholar Handbook host cells IFNg IFNL4 include MBL2 Meta-analysis Methodological quality pathogenic peer-reviewed PKR Population progression PROSPERO protocol registration number researcher review SARS-CoV-2 severe COVID-19 submitted systematic review systematic reviews Virus Disease Web of Science [DOI] 10.1097/MD.0000000000029405 PMC 바로가기 [Article Type] Article
Systematic review of host genetic association with Covid-19 prognosis and susceptibility: What have we learned in 2020?Covid-19 예후 및 감수성과 숙주 유전적 연관성에 대한 체계적인 검토: 2020년에 우리는 무엇을 배웠습니까?Review Published on 2022-03-012022-09-11 Journal: Reviews in Medical Virology [Category] SARS, 변종, [키워드] ABO ACE1 ACE2 analyzed ApoE association associations available data candidate candidate gene candidate genetic variants claimed clinical manifestation complex interaction COVID-19 COVID-19 prognosis COVID-19 severity database disease Effects eligible environmental factors evaluated examined Exome exome sequencing FIVE furin Genes Genetic genetic association Genetic association studies genetic variants GWAS Health healthcare heterogeneous HLA Host IFITM3 IFNL3 IFNL4 IMPROVE indicated Infection locus Meta-analysis moderate outcome outcomes pathophysiology performed Polymorphisms predict Prognosis recommendations reduce replicate Replication reported Research SARS-CoV-2 SARS-COV-2 infection Sequencing severity susceptibility TMPRSS2 whole-genome [DOI] 10.1002/rmv.2283 PMC 바로가기 [Article Type] Review
Are angiotensin converting enzyme (ACE1/ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A single-center cohort study안지오텐신 전환 효소(ACE1/ACE2) 유전자 변이가 COVID-19 폐렴의 임상 중증도와 관련이 있습니까? 단일 센터 코호트 연구Article Published on 2022-02-012022-09-11 Journal: Anatolian journal of cardiology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] abnormality ACE ACE gene ACE1 ACE1 gene ACE1/ACE2 ACE2 ACE2 gene Admission age allele Analysis angiotensin angiotensin converting enzyme automated Bioinformatics analysis Clinical characteristics Clinical severity Cohort cohort study coronavirus disease Coronavirus disease 2019 COVID-19 determine disease severity DNA domain DSP enzyme exon 1 frequencies Frequency functional Genetic Genomic DNA Genotype group I/D polymorphism ICU independent predictor independent predictors intensive care intensive care unit investigated knowledge no effect non-ICU Older age other variant pandemic Patient patients hospitalized Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Pneumonia polymorphism Polymorphisms purified radiologic recent Sanger sequencing Science Sequencing analysis severe disease single-center statistical analysis Statistical Package variant was performed was used [DOI] 10.5152/AnatolJCardiol.2021.502 PMC 바로가기 [Article Type] Article
Assessment of ACE1 variants and ACE1/ACE2 expression in COVID-19 patientsCOVID-19 환자에서 ACE1 변이체 및 ACE1/ACE2 발현 평가Article Published on 2022-02-012022-09-11 Journal: Vascular pharmacology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE ACE1 ACE1 gene ACE1/ACE2 ACE2 ACE2 expression Affect allele angiotensinogen assessment association carrier carriers circulation Complication Control controls COVID-19 COVID-19 patient distribution ether examined expression expression level expression levels Expression. Frequency Genotype genotyped genotypes groups healthy controls I/D polymorphism ICU patient ICU Patients mRNA level non-ICU non-ICU patient non-ICU patients not different not significantly different p value Patient patients polymorphism Renin risk of COVID-19 significantly higher study groups total population transcripts two group two groups variant while [DOI] 10.1016/j.vph.2021.106934 PMC 바로가기 [Article Type] Article
Vascular Effects of Low-Dose ACE2 Inhibitor MLN-4760—Benefit or Detriment in Essential Hypertension?Article Published on 2021-12-242022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] ACE1 ACE2 ACE2 inhibitor acute respiratory syndrome Administered Angiogenesis angiotensin-converting enzyme 2 bind blood pressure CAM cardiovascular system chick chorioallantoic compensatory mechanism complex Coronavirus-2 correlated detrimental detrimental effect Effect Essential essential hypertension host cell Hydrogen sulfide hypertensive infect inhibitor low dose Mas receptors membrane MLN-4760 nitric oxide organism Pathologies plasma Protective effects provide receptor renin-angiotensin system SARS-CoV-2 Signal transduction small artery [DOI] 10.3390/biomedicines10010038 PMC 바로가기 [Article Type] Article