ACE2 protein – Page 2 – Communicable Diseases Research

ACE2-based capacitance sensor for rapid native SARS-CoV-2 detection in biological fluids and its correlation with real-time PCR

생물학적 유체에서 신속한 기본 SARS-CoV-2 감지 및 Real-Time PCR과의 상관 관계를 위한 ACE2 기반 정전 용량 센서

Article

Published on 2022-04-152022-09-11
Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, 치료제,

Generalized Methodology for the Quick Prediction of Variant SARS-CoV-2 Spike Protein Binding Affinities with Human Angiotensin-Converting Enzyme II

변종 SARS-CoV-2 스파이크 단백질 결합 친화도와 인간 안지오텐신 전환 효소 II의 빠른 예측을 위한 일반화된 방법론

Article

Published on 2022-03-312022-09-11
Journal: The journal of physical chemistry. B [Category] SARS, 변종,

ACE2 protein expression in lung tissues of severe COVID-19 infection

중증 코비드 -19 감염의 폐 조직에서의 ACE2 단백질 발현

Article

Published on 2022-03-082022-09-01
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 진단, 치료기술,

[키워드] ACE2 ACE2 expression ACE2 protein acute lung injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alveolar damage angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antigen Biomarkers bronchopneumonia CD163 cells Complication controls Coronavirus-2 Correlation analysis COVID-19 COVID-19 disease DAD died Diffuse alveolar damage disease severity Diseases enzyme expression Histomorphology host protein Hypothesis hypothesised IHC immunohistochemistry immunostaining increased expression increased risk indications lung Lung injury lung tissue Macrophage Macrophage infiltration macrophages Medical research microthrombi Molecular biology non-COVID-19 patient Non-COVID-19 patients Pathogenesis Patient performed Platelet positively correlated post-mortem lung Protein protein expression random respiratory Risk factors Sample size SARS-CoV-2 SARS-CoV-2 viral Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 severe COVID-19 disease Severe COVID-19 Infection Severe infection significantly higher subset tested tissue Viral Virus Disease was performed were used
[DOI] 10.1038/s41598-022-07918-6 PMC 바로가기 [Article Type] Article

Development of targeted nanoparticles loaded with antiviral drugs for SARS-CoV-2 inhibition

SARS-CoV-2 억제용 항바이러스제를 탑재한 표적 나노입자 개발

Article

Published on 2022-03-052022-09-11
Journal: European journal of medicinal chemistry [Category] SARS, 치료제,

[키워드] ACE2 ACE2 binding site ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 Antiviral antiviral activity antiviral drug Antiviral effect antiviral therapeutics binding carriers Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 development Effectiveness etiological agent evaluated example exhibited host cells identify in viral infected Vero E6 cells Intervention Ligand ligands mechanism membrane Novel coronavirus pandemic Perspective pharmacological plethora prophylactic treatment pulmonary tract raised RDV receptor Regulatory Remdesivir representing Safe SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly Specific specificity Spike protein Targeted drug delivery Targeted nanoparticles. targets tested therapy for COVID-19 translation Vaccines Vero E6 VERO E6 cells viral entry viral particle Viral particles would increase
[DOI] 10.1016/j.ejmech.2022.114121 PMC 바로가기 [Article Type] Article

Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression

K18-hACE2 마우스의 치명적인 신경 보급 및 SARS-CoV-2 향성은 hACE2 발현에 부분적으로만 의존합니다

Article

Published on 2022-03-052022-09-11
Journal: Viruses [Category] SARS, 치료기술,

[키워드] ACE2 ACE2 protein ACE2-expressing cell ACE2-expressing cells Analysis angiotensin animal animal models AT1 axonal transport blood-brain barrier Brain bronchiolar Cell Cohort comparative pathology COVID-19 Critical cytokeratin cytokeratin 18 promoter days post-infection death Dependent detectable dose ENhance epidemiological data euthanasia evaluated Evidence expressing expression hACE2 Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hypothermia immunohistochemistry In situ hybridization in vivo in vivo imaging independent independent of inoculated intranasal K18-hACE2 Lineage Mild-to-moderate neuroepithelium Neuron neurons occur olfactory olfactory bulb olfactory neuroepithelium overexpression pathologic PFUs Pneumocytes Pneumonia portal question resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis spatiotemporal subsequent transgenic mice translational translational animal model Transmission transmission electron microscopy Transport tropism vasculature viral pathogenesis Viremia Virological
[DOI] 10.3390/v14030535 PMC 바로가기 [Article Type] Article

The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression

OM-85 박테리아 용해물은 SARS-CoV-2 수용체 발현을 하향 조절하여 상피 세포의 SARS-CoV-2 감염을 억제합니다

Article

Published on 2022-03-012022-09-11
Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 비임상, 유전자 메커니즘,

[키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 administration airway airway epithelial cells angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bacteria Bacterial bacterial lysate binding bronchial epithelial cells caused Cell cell entry cell interactions cell lines coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 downregulated downregulating downregulation Effect enzyme epithelial epithelial cell epithelial cell line epithelial cells expression HEK293T cell host cells human airway human epithelial cell human epithelial cells immunomodulating in vitro infect Infection inhibit inhibited Interaction intestinal kidney lentiviral particles lentivirus lung mRNA Multiple OM-85 organ organs Prevent primary bronchial epithelial cells primary human bronchial epithelial cells protease PROTECT Protein Protein binding protein expression pseudotyped lentiviral particles reduce respiratory infections S protein S1 protein safety profile SARS-CoV-2 SARS-CoV-2 cell infection SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 S1 protein Serine serine 2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity significantly TMPRSS2 Transcription transmembrane transmembrane protease serine 2 treated Treatment were measured
[DOI] 10.1016/j.jaci.2021.11.019 PMC 바로가기 [Article Type] Article

Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants

설계된 ACE2 디코이는 SARS-CoV-2 변종으로 인한 폐 손상 및 사망을 완화합니다.

Article

Published on 2022-03-012022-09-11
Journal: Nature chemical biology [Category] SARS, 변종, 치료제,

[키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity Alpha Amino acid amino acid substitution angiotensin angiotensin-converting enzyme 2 assays B.1.1.7 B.1.351 B.1.617.2 Beta binding affinity coronavirus COVID-19 therapeutics death Delta edema Efficacy feature functional Gamma highlight humanized IgG1 immune responses in vivo injection K18-hACE2 mice lung Lung injury mice mitigate molecular dynamics Molecular dynamics simulation molecular dynamics simulations P.1 P.1 variant prevented Prophylactic Protein S protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus soluble ACE2 survival the S protein the SARS-CoV-2 therapeutic therapeutic potential urgency Vaccine hesitancy vaccine-induced immune response vaccine-induced immune responses variants variants of concern Vascular injury VOCs
[DOI] 10.1038/s41589-021-00965-6 PMC 바로가기 [Article Type] Article

The ACE2 Receptor for Coronavirus Entry Is Localized at Apical Cell—Cell Junctions of Epithelial Cells

Article

Published on 2022-02-112022-10-31
Journal: Cells [Category] Coronavirus,

Polymorphisms in ACE, ACE2, AGTR1 genes and severity of COVID-19 disease

ACE, ACE2, AGTR1 유전자 및 COVID-19 질병의 중증도의 다형성

Research Article

Published on 2022-02-042022-09-10
Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종,

[키워드] 95%CI ACE ACE gene ACE2 ACE2 protein admitted to ICU age AGTR1 Analysis analyzed angiotensin association Cancer Cell Clinical course collected Comorbidities Comorbidity Course COVID-19 disease COVID-19 infection COVID-19 patient COVID-19 patients death death group Deceased demonstrated diabetes disease distribution evidenced exaggerated inflammatory response expected G/A Gender Genetic Genetic variant Genotype greater Hardy-Weinberg equilibrium Hospitalization Hospitalized Human hypertension I/D ICU increased risk increased the risk Infection inheritance intensive care unit lead Lung disease male marker modulate multivariable multivariable analysis nucleotide obesity Older age Outpatient outpatients patients with comorbidities patients with COVID-19 produced protector recessive model regulator Renin renin-angiotensin system Result risk rs1978124 rs2285666 SARS-CoV-2 SARS-CoV-2 virus selected severity severity of COVID-19 Severity of disease Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility susceptibility to infection the cell the disease the severity group virus while
[DOI] 10.1371/journal.pone.0263140 PMC 바로가기 [Article Type] Research Article

A Comparative and Comprehensive Review of Antibody Applications in the Treatment of Lung Disease

Review

Published on 2022-01-172022-10-29
Journal: International Review of Cell and Molecular Biology [Category] COVID-19,