Effect of plasma exchange on COVID-19 associated excess of von Willebrand factor and inflammation in critically ill patients Research Published on 2022-03-212022-10-05 Journal: Scientific Reports [Category] 치료법, [키워드] accompanied acute respiratory distress ADAMTS13 Antigen ARDS benefit C-reactive protein clinical parameter COVID-19 Critically ill patient cytokine Effect excess expiratory hospitals immunothrombosis Inflammation Inflammatory Inflammatory cytokine inflammatory state investigated lactate dehydrogenase monocyte chemotactic protein-1 on mechanical ventilation parameter parameters pathogenesis of COVID-19 Patient patients plasma plasma exchange Pneumonia positive reduce reduced reduction resulting sequence severe COVID-19 significant decrease significant increase significantly syndrome therapeutic option therapy vasculature Ventilation von Willebrand factor were assessed [DOI] 10.1038/s41598-022-08853-2 [Article Type] Research
Genetic prediction of ICU hospitalization and mortality in COVID-19 patients using artificial neural networks인공신경망을 이용한 코로나19 환자 중환자실 입원 및 사망률의 유전적 예측Article Published on 2022-03-012022-09-11 Journal: Journal of Cellular and Molecular Medicine [Category] 변종, [키워드] absence ADAMTS13 age age and gender ANN artificial intelligence Artificial neural network C3a CD46 CD55 CFB CFD CFH CFHR1 CFI Clinical outcome clinical outcomes complement complement inhibition coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical death death in COVID-19 develop disintegrin dysregulation examined Gender Genes Genetic genetic susceptibility genetic susceptibility. Genetic variant genetic variants Hospitalization Hospitalized ICU identified variant identify metalloproteinase morbidity morbidity and mortality Mortality motif Next-generation sequencing outcome Patient patients phenotype presence or absence recruited SARS-CoV2 severe COVID-19 severe COVID-19 patient severe COVID-19 patients significantly increased THBD thrombomodulin Thrombospondin unmet need variant variants [DOI] 10.1111/jcmm.17098 PMC 바로가기 [Article Type] Article
Obstetric outcomes in pregnant COVID-19 women: the imbalance of von Willebrand factor and ADAMTS13 axis임신 한 Covid-19 여성의 산과 적 결과 : Von Willebrand Factor and Adamts13 축의 불균형Observational Study Published on 2022-02-212022-09-10 Journal: BMC Pregnancy and Childbirth [Category] COVID19(2023년), Fulltext, MERS, SARS, 바이오마커, 유전자 메커니즘, 임상, [키워드] 95%CI AB0 blood group system ADA ADAMTS13 Admission adverse outcomes age association Asymptomatic Biomarker clinical information clinical outcomes collected confounders COVID-19 COVID-19 patient COVID-19 patients damage Decision making decision making process demographic diagnosis of SARS-CoV-2 discharge evaluate Follow-up gestational age hospital Hospital admission Imbalance independent Infection investigated Italy laboratory data laboratory parameter Laboratory parameters laboratory-confirmed Logistic regression Logistic regression analysis marker mechanism median microangiopathy monitoring outcome Pregnancy pregnant pregnant women preterm delivery regression analysis responsible Result risk SARS-COV-2 infection significantly significantly higher significantly lower Support Symptom symptom of infection thrombotic microangiopathy von Willebrand factor was performed with COVID-19 [DOI] 10.1186/s12884-022-04405-8 PMC 바로가기 [Article Type] Observational Study
The Impact of Age and BMI on the VWF/ADAMTS13 Axis and Simultaneous Thrombin and Plasmin Generation in Hospitalized COVID-19 PatientsMedicine Published on 2022-01-102022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ADAMTS13 addition age aging Analysis analyzed Antigen axis binding activity BMI body mass index Coagulation Coagulopathy collagen collected conditions contribute contributed Corona COVID-19 COVID-19 negative cross-sectional elevated endothelial Endothelial dysfunction factor VIII Generation Health hospital Impact increases in increasing age individual obesity Older parameter Patient plasma plasmin populations positive reduced risk severity Simultaneous thrombin von Willebrand factor vWF [DOI] 10.3389/fmed.2021.817305 PMC 바로가기 [Article Type] Medicine
Case series: coronavirus disease 2019 infection as a precipitant of atypical hemolytic uremic syndrome: two case reportsCase Report Published on 2021-12-132022-10-30 Journal: Journal of Medical Case Reports [Category] COVID-19, SARS, [키워드] accelerated Activation ADAMTS13 Adults Atypical Atypical hemolytic uremic syndrome Case report case sery caused Complement pathway Complete complications coronavirus disease COVID-19 female had no hematologic Hemodialysis hemolytic anemia Hispanic Infection influenza A knowledge Laboratory male Nonimmune hemolytic anemia Patient precipitated presenting renal reported SARS-CoV-2 thrombotic thrombotic microangiopathy treated uremic uremic syndrome [DOI] 10.1186/s13256-021-03144-2 PMC 바로가기 [Article Type] Case Report
MEDTEC Students against Coronavirus: Investigating the Role of Hemostatic Genes in the Predisposition to COVID-19 SeverityArticle Published on 2021-11-092022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] MTHFR 95%CI acute respiratory syndrome ADAMTS13 Analysis association Association analysis Characteristics characterized clinical heterogeneity Cohort conducted Control coronavirus coronavirus disease COVID-19 COVID-19 severity database degree distribution Engineering evidenced extreme functions General population Genes Genetic Genetic predisposition Hemostasis Hemostatic hemostatic genes Host intrinsic investigated Italian Manifestations median Medicine Meta-analysis MTHFR MTR pandemic performed polygenic risk score polymorphism predicted predisposition PROC Regeneron risk role SARS-CoV-2 severe COVID-19 severe COVID-19 patient severity significantly single-nucleotide student susceptibility THBS2 the disease Thromboembolic events university variant virus with COVID-19 [DOI] 10.3390/jpm11111166 PMC 바로가기 [Article Type] Article
Shedding Light on the Possible Link between ADAMTS13 and Vaccine—Induced Thrombotic ThrombocytopeniaADAMTS13과 백신 사이의 가능한 연관성에 대한 조명 - 유도된 혈전성 혈소판 감소증Commentary Published on 2021-10-182022-09-11 Journal: Cells [Category] MERS, 유전자 메커니즘, 진단, [키워드] ADAMTS13 antibody AstraZeneca Blood blood clotting can not Capillaries ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine circulating platelet complex complexes conservation COVID-19 Critical enzyme event in some LIGHT observation Pathogenesis PF4 Platelet platelet factor 4 Platelets potential mechanism presenting Protein proteolytic activity raise recipient reduce SARS-CoV-2 shedding stability subject thrombocytopenia thrombosis thrombotic Thrombus thrombus formation titre Vaccine von Willebrand factor vWF [DOI] 10.3390/cells10102785 PMC 바로가기 [Article Type] Commentary
Age-Associated Increase in Thrombogenicity and Its Correlation with von Willebrand FactorReview Published on 2021-09-162022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ADAMTS13 aggregate aging Anticoagulant blood flow blood vessel Cell Coagulopathy Consequences COVID-19 dysfunction Endothelial cell endothelial cells Express expression Factor function Hemostasis increase increase in inherent Injury maintain physiological Platelet platelet aggregates potential mechanisms procoagulant Protein Regulation significant increase thrombogenicity thrombosis Thrombotic events Thrombus von Willebrand factor vWF [DOI] 10.3390/jcm10184190 PMC 바로가기 [Article Type] Review
Imbalance of von Willebrand factor and ADAMTS13 axis is rather a biomarker of strong inflammation and endothelial damage than a cause of thrombotic process in critically ill COVID-19 patients폰 빌레브란트 인자와 ADAMTS13 축의 불균형은 코로나19 중환자에서 혈전 과정의 원인이라기보다는 오히려 강한 염증과 내피 손상의 바이오마커Article Published on 2021-09-012022-09-11 Journal: Journal of thrombosis and haemostasis : JTH [Category] SARS, 바이오마커, [키워드] ADAMTS13 ADAMTS13 conformation Admission alveolar capillaries alveolar capillary Antigen Biological Biomarker Biomarkers Clinical features contribute coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients D-dimer deaths deficiency disintegrin driver Drivers elevated endothelial damage enrolled factor V fibrinogen hallmark hemolytic anemia hospital Imbalance Immune-mediated induce Inflammation Laboratory parameters male-to-female ratio median age microangiopathic hemolytic anemia microthrombi Microthrombosis Mortality open Patient patients Platelet Pulmonary embolism pulmonary embolisms purpura Quantitative reported Seven severe deficiency specificity thrombocytopenia thrombocytopenic purpura thrombotic thrombotic microangiopathy Thrombotic thrombocytopenic purpura type I von Willebrand factor vWF [DOI] 10.1111/jth.15445 PMC 바로가기 [Article Type] Article
Complement levels at admission as a reflection of coronavirus disease 2019 (COVID-19) severity state코로나바이러스 질병 2019(COVID-19) 심각도 상태를 반영하여 입원 시 보완 수준Article Published on 2021-09-012022-09-11 Journal: Journal of medical virology [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus 2 ADAMTS13 Admission adverse outcome adverse outcomes analyzed association benefit Blood blood sample Blood samples C3a C3a/C3 Clinical improvement complement complement system confounders coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation correlations Course COVID-19 COVID-19 illness COVID-19 patient COVID-19 severity disease severity displaying elevated emergency department enrolled Evidence evidence of fibrinogen highest Hyperactivation hyperinflammation Hyperinflammatory implicated infected patients inflammatory biomarkers investigated moderate organ damage over parameter Patient phenotype plasminogen predict presenting Primary outcome progression Research respiratory SARS-CoV-2 SARS-CoV-2 hyperinflammation secondary outcome severe acute respiratory syndrome Coronavirus severe COVID-19 illness severe disease severity significantly therapy thrombotic thrombotic microangiopathy tissue [DOI] 10.1002/jmv.27077 PMC 바로가기 [Article Type] Article