Symptomatology during previous SARS-CoV-2 infection and serostatus before vaccination influence the immunogenicity of BNT162b2 COVID-19 mRNA vaccineArticle Published on 2022-10-142023-07-10 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] Adaptive immune response COVID-19 Hybrid immunity mRNA vaccination SARS-CoV-2 [DOI] 10.3389/fimmu.2022.930252 PMC 바로가기
Contribution of T- and B-cell intrinsic toll-like receptors to the adaptive immune response in viral infectious diseasesarticle Published on 2022-10-122024-09-02 Journal: Cellular and Molecular Life Sciences [Category] 대상포진, [키워드] Adaptive immune response B cells Immunotherapy T cells Toll-like receptor viral infection [DOI] 10.1007/s00018-022-04582-x PMC 바로가기 [Article Type] article
Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adultsArticle Published on 2022-10-042022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Activation Adaptive immune response antibodies antibody BCG BCG vaccination benefit booster breadth CD4+ CD8+ T-cell changes changes in chromatin Combination COVID-19 vaccines Delta Effect effector memory eight elevated ENhance Epigenetic Evidence expressing greater Heterologous highlighting IL-1β IL-2 immune response Immunity in-depth analysis India marker memory T-cell response mutant NAb Neutralizing provide revaccination SARS-CoV-2 seronegative significantly higher subset T cell T-cell Response tested TNF-α TNF-α expression trained immunity Tuberculosis vaccination Vaccine vaccine-induced immune response [DOI] 10.3389/fimmu.2022.985938 PMC 바로가기
Longitudinal mapping of hepatitis B vaccine-induced B-cell linear epitopes in healthy individualsArticle Published on 2022-10-012023-05-31 Journal: Journal of medical virology [Category] A형 간염, B형 간염, [키워드] a determinant region Adaptive immune response B-cell linear epitopes Hepatitis B vaccination peptide mapping. [DOI] 10.1002/jmv.27926
Comparison between enzyme-linked immunospot assay and intracellular cytokine flow cytometry assays for the evaluation of T cell response to SARS-CoV-2 after symptomatic COVID-19Article Published on 2022-10-012022-11-15 Journal: Immunity, Inflammation and Disease [Category] COVID19(2023년), SARS, 치료기술, [키워드] absence Adaptive immune response anti-SARS-CoV-2 assays cellular cellular immunity correlated COVID-19 Culture detectable ELISPOT ELISpot assay enzyme-linked immunospot assay flow cytometry assay ICS Immunity IMPROVE intracellular cytokine intracellular cytokine staining intracellular cytokine staining assay magnitude median memory T memory T cells mononuclear cell nucleoprotein of SARS-CoV-2 Patient patients paucisymptomatic COVID-19. peptide pool performed Peripheral blood positive proportion response SARS-CoV-2 severe COVID-19 severe disease severe symptoms symptomatic T cell T cell response T cells the spike protein Vaccine-induced immunity [DOI] 10.1002/iid3.617 PMC 바로가기
Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathologyArticle Published on 2022-09-292022-11-15 Journal: Vaccine [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome Adaptive immune response addition antibodies antibody Beta Cell coronavirus coronavirus disease COVID-19 COVID-19 vaccines CpG cross-protective develop feature Gamma IgA antibody IgG antibody immunopathology Infection initial intranasal intranasal vaccination intranasally investigated less lung Lung eosinophilic immunopathology Lymph node mice mucosa nasal nasal mucosa oligonucleotides pandemic potential risk Prevent Protective protective effect reducing Respiratory disease risk SARS-CoV-2 SARS-CoV-2 variant secretory secretory IgA secretory IgA antibody. serum spike-specific IgG subcutaneous vaccination subcutaneously T helper Th1 Th2 Trimeric spike protein upper respiratory tract vaccination Vaccine variant variants viral challenge virus infection viruses [DOI] 10.1016/j.vaccine.2022.08.049 PMC 바로가기
Correlation between Type I Interferon Associated Factors and COVID-19 SeverityArticle Published on 2022-09-192022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] acute respiratory syndrome Adaptive immune response Affect Antiviral antiviral response caused cells Chronic diseases conditions coronavirus COVID-19 COVID-19 severity declined dendritic cell dysfunction dysregulation early phase Factor Factors Frequency IFN IFN response IFN signature increased risk individual individual immune response inhibit magnitude Mild no symptoms Patient plasmacytoid dendritic cell plasmacytoid dendritic cell 1 Prevent produced producing promote response responsible risk risk factor SARS-CoV-2 severe coronavirus disease severe COVID-19 tissue damage Type type I Type I IFN type I IFNs type I interferon viral infection viral infections viral replication viruses [DOI] 10.3390/ijms231810968 PMC 바로가기
Prospects of animal models and their application in studies on adaptive immunity to SARS-CoV-2Article Published on 2022-09-162022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] adaptive Adaptive immune response Adaptive immunity addition animal model anti-SARS-CoV-2 Antiviral Clinical studies clinical symptom COVID-19 cross-immune response drugs humans immune immune memory immune response Immunity in-depth analysis Infection limitation mechanism mechanisms persistence PROTECT Protective provide Research SARS-CoV-2 the SARS-CoV-2 thresholds tissue-resident immune response. Vaccine [DOI] 10.3389/fimmu.2022.993754 PMC 바로가기
IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spikeArticle Published on 2022-09-052022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] Adaptive immune response bind binding Cancer Cancer therapy cells cleavage cleave enzyme expressed expression facilitate homology identify IL4I1 immune immunosuppressive immunosuppressive enzymes Immunotherapy involved Lymphocytes mechanism of action monocyte Monocyte-derived macrophages moonlighting protein negative control Protease activity Protein Pseudotyped virus Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein secreted spike surface protein survival the spike protein TMPRSS13 TMPRSS2 transmembrane serine protease virus [DOI] 10.3389/fimmu.2022.982839 PMC 바로가기
Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccinationArticle Published on 2022-09-022022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] adaptive Adaptive immune response adaptive immune responses addition antibody antibody production B cells B-cell BCR component COVID-19 Critical develop effective flow cytometry immune immune protection immune response Infection Measures molecular mechanism natural infection offer pandemic Pathogenesis Protective recent receptor SARS-CoV-2 SARS-COV-2 infection severity single-cell single-cell analysis Support T cell T-cell receptor TCR the disease therapeutic intervention transcriptomics vaccination Vaccine variants [DOI] 10.3389/fimmu.2022.964976 PMC 바로가기