Thrombotic Events in COVID-19 Are Associated With a Lower Use of Prophylactic Anticoagulation Before Hospitalization and Followed by Decreases in Platelet ReactivityMedicine Published on 2021-04-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 95% CI 95% confidence interval adjusted odds ratio ADP age all-cause mortality AOR association Asthma baseline blood sample clinical Clinical outcome control patient COVID-19 COVID-19 negative COVID-19 positive patient decrease determine develop disease enrolled expression flow cytometry followed by highlight Hospitalized hospitalized COVID-19 patient hypercoagulability incidence increased the risk less Lower nine Non-survivors outcome P-selectin Patient Platelet Platelets positive prothrombotic state provided pulmonary thrombosis reactivity retrospective cohort study risk SARS-CoV-2 significant difference survivor therapy Thromboinflammation Thromboprophylaxis thrombosis thrombotic thrombotic event Thrombotic events was determined with COVID-19 [DOI] 10.3389/fmed.2021.650129 PMC 바로가기 [Article Type] Medicine
In silico identification of compounds from Nigella sativa seed oil as potential inhibitors of SARS-CoV-2 targetsResearch Published on 2021-03-122022-10-28 Journal: Bulletin of the National Research Centre [Category] COVID-19, [키워드] β-bisabolene 3CLpro ACE2 ADP alleviate Angiotensin-converting enzyme binding affinity characterized claimed Compound COVID-19 infection COVID-19 pandemic docking enzyme fatality highest Homo sapiens identify infected individual inhibitors of SARS-CoV-2 molecular Nigella Sativa Patient phosphatase polyprotein protease replicase reported Result RNA binding protein RNA-dependent RNA polymerase RPIA SARS-CoV-2 SARS-CoV-2 receptors selective severity target targets viral infection was performed [DOI] 10.1186/s42269-021-00517-x PMC 바로가기 [Article Type] Research
COVID-19 induces a hyperactive phenotype in circulating plateletsResearch Article Published on 2021-02-172022-10-28 Journal: PLoS Biology [Category] COVID-19, MERS, [키워드] Admission ADP aetiology affected Analysis Blood caused circulating circulating platelet contribute Control controls coronavirus 2 COVID-19 COVID-19 patient demonstrated disease disease severity elevated Endothelial dysfunction Evidence full blood count healthy donor hospitalisation hospitalised hypercoagulability ICU in-patient induce Infection intensive care laboratory parameter marker MPV P-selectin parameter Patient PF4 phenotype Platelet Platelets reactivity reported respiratory reveal SARS-CoV-2 SARS-COV-2 infection secretion severe COVID-19 disease severity significantly the disease thrombotic risk TPO Venous Thromboembolism Volume with COVID-19 [DOI] 10.1371/journal.pbio.3001109 PMC 바로가기 [Article Type] Research Article
Spa47 is an oligomerization‐activated type three secretion system (T3SS) ATPase from Shigella flexneriSpa47은 Shigella flexneri에서 유래한 올리고머화 활성화 제3형 분비 시스템(T3SS) ATPase입니다.journal-article Published on 2016-05-012024-07-30 Journal: Protein Science [Category] 세균성이질, [키워드] ADP ATP ATPase oligomerization protein export type III secretion system (T3SS) virulence factor [DOI] 10.1002/pro.2917 [Article Type] journal-article
The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6 , a Gene Identified through Mining the DPH1 – DPH5 Interaction Network효모에서 디프타마이드 생합성의 아미드화 단계에는 DPH1 - DPH5 상호작용 네트워크 마이닝을 통해 확인된 유전자인 DPH6이 필요합니다Research Article Published on 2013-02-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate Accuracy adenine adenine nucleotide ADP Affect agent amidase Amino acid approach association ATP Author bind Biosynthesis biosynthetic biosynthetic pathway candidate candidate gene Cell cell growth characterized check Complete completion component components Corynebacterium diphtheriae defined Diphthamide dissociation domain DPH1 Dph5 Dph6 Dph7 eEF2 elongation factor embryogenesis enzyme evade expected failure Final form found generate Genes Genetic genetic interaction genomic growth histidine Identified identify inactivation indicated inhibitor inhibitors initial Interaction involved Like maintain mass spectrometry mice molecular mutant name network nucleotide observation pathogen pathway produced promote Protein protein synthesis Proteins Regulatory required residue response Saccharomyces cerevisiae step target trait translation translational upregulated [DOI] 10.1371/journal.pgen.1003334 PMC 바로가기 [Article Type] Research Article