Impact of Levosimendan and Its Metabolites on Platelet Activation Mechanisms in Patients during Antiplatelet Therapy—Pilot StudyArticle Published on 2024-02-022024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] ADP aggregation antiplatelet therapy levosimendan Platelets [DOI] 10.3390/ijms25031824 PMC 바로가기 [Article Type] Article
Is there an interplay between the SARS-CoV-2 spike protein and Platelet-Activating factor?Article Published on 2022-11-012023-07-10 Journal: BioFactors (Oxford, England) [Category] COVID19(2023년), [키워드] ADP collagen coronavirus human platelet-rich plasma Monocytes platelet-activating factor Platelets Spike protein thrombin Vaccines [DOI] 10.1002/biof.1877 PMC 바로가기
Operation of a triage committee for advanced life support during the COVID-19 pandemicObservational Study Published on 2022-03-162022-10-05 Journal: Philosophy, Ethics, and Humanities in Medicine : P [Category] 임상, [키워드] ADP affected age ALS candidate Clinical characteristics clinical criteria Comorbidity COVID-19 COVID-19 pandemic decision Decision-making determine effective Ethics Ethics Committees/Consultation evaluated First wave foundation functional Health help implementation include involved less male measure median Older operation Other participated Patient patients evaluated physician Public receive resources SARS CoV-2 severe respiratory failure Spain Support the patient Triage university [DOI] 10.1186/s13010-022-00117-1 PMC 바로가기 [Article Type] Observational Study
Role of CD39 in COVID-19 Severity: Dysregulation of Purinergic Signaling and ThromboinflammationCOVID-19 중증도에서 CD39의 역할: 퓨린성 신호 전달 및 혈소판 염증의 조절 장애Immunology Published on 2022-01-312022-09-11 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] 95%CI adenosine adjusted odds ratio Admission ADP association ATP Biomarker blocked caused CD39 clinical parameter Cohort contribute COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia COVID-19 severity disorder dysregulation expression Extracellular healthy control homeostasis Hospital stay Hypoxemia hypoxia ICU admission Immune cell indicate Inflammatory Influenza influenza A inhibitor intensive care intensive care unit admission maintain nucleotide nucleotides overexpressed overexpression pathophysiology pathway Patient patients hospitalized plasma platelet activation Pneumonia prospective cohort Purinergic purinergic dysregulation receptor resulting role selected Severe COVID-19 pneumonia severity Signaling subset suggested systemic inflammation Thromboinflammation ticagrelor was related [DOI] 10.3389/fimmu.2022.847894 PMC 바로가기 [Article Type] Immunology
In silico validation of coumarin derivatives as potential inhibitors against Main Protease, NSP10/NSP16-Methyltransferase, Phosphatase and Endoribonuclease of SARS CoV-2Article Published on 2021-11-012022-10-04 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, [키워드] ADME ADME/T ADP Analysis approach binding binding free energy caused combination therapy Compound coronavirus 2 coumarin COVID-19 COVID-19 infection derivative develop docked docking docking result docking score drug Drug repurposing drug-likeness endoribonuclease enzyme FIVE help identification IMPROVE in silico information inhibitor inhibitory activity Ligand LLC MD simulation molecular pandemic performed protease Protein provide radius of gyration receptor receptor protein respiratory RMSD SARS CoV-2 SARS-CoV-2 Seven stability therapy Treatment USA Virtual screening virus was performed were used WHO [DOI] 10.1080/07391102.2020.1808075 PMC 바로가기 [Article Type] Article
Absence of hypercoagulability after nCoV-19 vaccination: An observational pilot studynCoV-19 백신 접종 후 과응고의 부재: 관찰 파일럿 연구Observational Study Published on 2021-09-012022-09-11 Journal: Thrombosis research [Category] SARS, 임상, 치료기술, [키워드] activating Activation ADP age aggregation BNT162b2 BNT162b2 vaccine BNT162b2 vaccines Care carriers ChAdOx1 ChAdOx1 vaccine ChAdOx1 vaccines clinically Coagulation Cohort comparable control group controls COVID-19 COVID-19 vaccine COVID-19 vaccines eligible endogenous evaluated fibrinogen first dose Gender groups Health Health care healthy subject healthy subjects hypercoagulability hypercoagulable induce no difference no differences oral contraceptive oral contraceptives parameter peptide pilot study plasma Platelet platelet aggregation Platelet count predisposition professional prothrombotic state receptor SARS-CoV-2 subject thrombin Thrombin generation thrombin receptor Thrombophilia thrombosis TRAP university vaccination Vaccine Volunteer Whole blood women [DOI] 10.1016/j.thromres.2021.06.016 PMC 바로가기 [Article Type] Observational Study
Repurposing FDA-approved drugs against multiple proteins of SARS-CoV-2: An in silico studyResearch article Published on 2021-09-012022-10-05 Journal: Scientific African [Category] 신약개발, [키워드] 3CLpro ACE2 ADP approach approved drug binding binding energy clinical study complexes Compound Control COVID-19 COVID-19 pandemic Discovery Studio docked drug Drug repurposing drug target DrugBank drugs Effectiveness enzyme ethynodiol FDA FDA-approved drug food greater in silico In silico methods less Ligand Lopinavir lower binding energy lowest molecular weight phosphatase protease Protein Proteins ranged RdRP replicase repurposing RNA RNA binding protein RNA polymerase SARS CoV-2 screened target proteins Target-based docking the disease therapeutic drug UCSF Chimera virus were used Withdrawal [DOI] 10.1016/j.sciaf.2021.e00845 [Article Type] Research article
Strawberry and Ginger Silver Nanoparticles as Potential Inhibitors for SARS-CoV-2 Assisted by In Silico Modeling and Metabolic ProfilingArticle Published on 2021-07-062022-10-27 Journal: Antibiotics [Category] COVID-19, [키워드] AAK1 ADP AgNP AgNPs Analysis anti-SARS-CoV-2 Antiviral antiviral activity AutoDock biosynthesized carried cathepsin caused Compound conducted COVID-19 demonstrated docking study drug candidate evaluated fatty acids FIVE Fragaria ginger globe Health high stability High-resolution highest Human in silico In silico modeling indicate inhibitor inhibitory Interaction life-threatening metabolic metabolomic profiling Microscope modeling molecular molecular docking MPro MTT nanoparticle Nanoparticles Novel coronavirus overcome pandemic phosphatase PLPro Pneumonia Potential predict Profiling Protein Proteins provide responsible SARS-CoV-2 SARS-CoV-2 protein Secondary Metabolite Seven silver spectrophotometric analysis strawberry target TEM the SARS-CoV-2 Transmission Viral protein was performed were used zeta potential Zingiber [DOI] 10.3390/antibiotics10070824 PMC 바로가기 [Article Type] Article
Distinct phenotypes of platelet, monocyte, and neutrophil activation occur during the acute and convalescent phase of COVID-19혈소판, 단핵구 및 호중구 활성화의 뚜렷한 표현형은 COVID-19의 급성 및 회복기에 발생합니다Clinical Trial Published on 2021-05-172022-08-13 Journal: Platelets [Category] MERS, SARS, 임상, [키워드] Activation acute phase ADP analyzed baseline Blood platelets blood sample Blood samples CD62P contribute convalescent convalescent phase COVID-19 COVID-19 in patient COVID-19 pandemic cytokine cytokine level determined by Disease progression ELISA expression flow cytometry heterogeneous IL-10 IL-6 Inclusion Interaction less leukocyte leukocyte activation leukocytes majority monocyte Monocyte activation neutrophil neutrophil activation Neutrophils occur Patient phenotype Platelet platelet activation platelet-leukocyte complex formation platelet-monocyte complex formation Platelets procoagulant status recruited released SARS-CoV-2 significantly higher significantly lower Spread thrombin thrombin- thromboembolic Thromboembolic event Thromboembolic events [DOI] 10.1080/09537104.2021.1921721 PMC 바로가기 [Article Type] Clinical Trial
Decay of Fc-dependent antibody functions after mild to moderate COVID-19Article Published on 2021-05-092023-06-15 Journal: Cell Reports Medicine [Category] MERS, SARS, [키워드] ADCC ADP antibody convalescence COVID-19 decay Fc effector functions phagocytosis SARS-CoV-2 trogocytosis [DOI] 10.1016/j.xcrm.2021.100296 PMC 바로가기 [Article Type] Article