Computational Analysis of Missense Variants in the Human Transmembrane Protease Serine 2 ( TMPRSS2 ) and SARS-CoV-2인간 막 횡단 프로테아제 세린 2 (TMPRSS2) 및 SARS-COV-2에서의 미스 센스 변이체의 계산 분석Research Article Published on 2021-10-192022-09-10 Journal: BioMed Research International [Category] 변종, [키워드] 3D structure activating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADP-ribosylation association cleaving conserved ConSurf coronavirus decrease Deleterious deleterious effect deleterious effects Effect evaluated facilitate Human identify missense variant mutant posttranslational modification PROCHECK progression Prostate cancer protease Protein proteolytic cleavage PROVEAN PTMs Ramachandran plot respiratory S protein SARS-CoV-2 Serine serine 2 severe acute respiratory syndrome Coronavirus SIFT stability susceptibility target cell target cells Template tested the S protein TMPRSS2 transmembrane variant Viral viral entry [DOI] 10.1155/2021/9982729 PMC 바로가기 [Article Type] Research Article
The History of Pertussis Toxin백일해 독소의 역사Review Published on 2021-09-052024-07-28 Journal: Toxins [Category] 백일해, [키워드] ADP-ribosylation G proteins histamine sensitization islet activation Leukocytosis pertussis vaccines [DOI] 10.3390/toxins13090623 PMC 바로가기 [Article Type] Review
β-Carboline alkaloids induce structural plasticity and inhibition of SARS-CoV-2 nsp3 macrodomain more potently than remdesivir metabolite GS-441524: computational approachArticle Published on 2021-08-302022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] β-carboline ADP-ribose ADP-ribosylation analogue anti-SARS-CoV-2 approach binding affinity binding free energy bioinformatics candidate computational approach coronavirus creating database demonstrated docking docking score drug design Glide GS-441524 Host immune response implicated indicated induce Infection Ligand ligands low expression macrodomain macromolecule metabolite modulated Molecular dynamics simulation Nsp3 nsp3 macrodomain parameter Pathogenesis plasticity predicted receptor Remdesivir reported SARS-CoV-2 screened selected small molecule stability the SARS-CoV-2 Toxicity viral replication [DOI] 10.3906/biy-2106-64 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signalingResearch Article Published on 2021-08-042022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS, [키워드] Activation ADP-ribosylation Antiviral binding can be used cascade catalyzed cellular coronavirus coronavirus pathogenesis COVID-19 dependent on downstream DTX3L ectopic expression expression Genes Host host protein human cells IFN IFN response IFN signaling IFN, interferon impair induce inhibitors interferon interferon signaling ISG, Interferon-stimulated gene macrodomain Modification nonstructural protein 3 Nsp3, nonstructural protein 3 PARP, poly(ADP-ribose) polymerase PARP9 PARPs polymerase Protein robust SARS-CoV-2 suppress target the SARS-CoV-2 thought [DOI] 10.1016/j.jbc.2021.101041 PMC 바로가기 [Article Type] Research Article
High-Throughput Screening and Quantum Mechanics for Identifying Potent Inhibitors Against Mac1 Domain of SARS-CoV-2 Nsp3SARS-CoV-2 Nsp3의 Mac1 도메인에 대한 강력한 억제제를 식별하기 위한 고성능 스크리닝 및 양자 역학Article Published on 2021-07-012022-09-11 Journal: IEEE/ACM transactions on computational biology and [Category] SARS, 치료제, [키워드] acceptor ADP-ribose ADP-ribosylation Against Antiviral antiviral activity binding binding pocket compounds conserved coronavirus CoV database docking domain Donor drug target electron donor ENCODE enzymatic activity enzyme host response identifying inhibitor inhibitors Interaction Mac1 Mechanics molecular dynamics mono nonstructural protein 3 Nsp3 other coronaviruses pathogenicity phosphate potent protein 3 provide quantum regions Regulatory residue ribose SARS-CoV-2 Screening substrate Tight binding unique viral infections virulence virulence factor Zinc [DOI] 10.1109/TCBB.2020.3037136 PMC 바로가기 [Article Type] Article
In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 InfectionResearch Article Published on 2021-04-092022-10-27 Journal: BioMed Research International [Category] [키워드] ACE2 ACE2 protein ADP-ribosylation analyzed Angiotensin-converting enzyme bioinformatics ConSurf cumulative score Deleterious functional Human human host cell in silico analysis information less missense variant Modification nucleotide pathogenic Protein proteolytic cleavage PROVEAN provide receptor SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus SIFT stability susceptibility variant were used [DOI] 10.1155/2021/6685840 PMC 바로가기 [Article Type] Research Article
In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 InfectionResearch Article Published on 2021-04-092022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 protein ADP-ribosylation analyzed Angiotensin-converting enzyme bioinformatics ConSurf cumulative score Deleterious functional Human human host cell in silico analysis information less missense variant Modification nucleotide pathogenic Protein proteolytic cleavage PROVEAN provide receptor SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus SIFT stability susceptibility variant were used [DOI] 10.1155/2021/6685840 PMC 바로가기 [Article Type] Research Article
In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 Infection인간 ACE2 유전자의 고위험 미스센스 변이체 및 SARS-CoV-2 감염에 대한 감수성의 실리코 분석Research Article Published on 2021-04-092022-09-10 Journal: BioMed Research International [Category] 변종, [키워드] ACE2 ACE2 protein ADP-ribosylation analyzed angiotensin Angiotensin II Angiotensin-converting enzyme bioinformatics ConSurf conversion coronavirus cumulative score Deleterious functional host cells Human human host cell human host cells in silico analysis information less missense variant Modification nucleotide pathogenic Protein protein structure proteolytic cleavage PROVEAN provide receptor SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus SIFT stability STRING susceptibility variant were used [DOI] 10.1155/2021/6685840 PMC 바로가기 [Article Type] Research Article
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunityMetabolism Published on 2021-01-132022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS, [키워드] Activation activity ADP-ribose ADP-ribosylation antiviral activity antiviral responses biosynthetic boost cellular coronavirus Coronaviruses COVID-19 decrease demonstrated DNA damage ENhance enzyme expression expression of gene gene transcription host cell induce Infection Innate immunity interferon isozyme MHV murine hepatitis virus NAD biosynthesis NADP NAMPT nicotinamide nicotinamide adenine dinucleotide (NAD) nicotinamide riboside overexpression PARP PARP10 PARP12 PARP14 PARP7 Pathways pharmacological pharmacological intervention plus-stranded RNA virus poly(ADP-ribose) polymerase polymerase post-translational modification (PTM) Protein Replication RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 transcriptionally transcriptomics up-regulate [DOI] 10.1074/jbc.RA120.015138 PMC 바로가기 [Article Type] Metabolism
Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential201 Published on 2020-11-182022-10-29 Journal: Open Biology [Category] COVID-19, [키워드] (ADP-ribosyl)hydrolase ADP-ribosylation adverse effect alphavirus Analysis Antiviral antiviral poly(ADP-ribosyl)polymerases binding cellular conserved Coronaviral coronavirus COVID-19 cross-reactivity disease drug design evaluate Features homology Host human macrodomain hydrolysis immune response implicated infections kidney Ligand macrodomain Necrosis non-structural protein 3 PARP14 pharmacological post-translational modification raised Regulation SARS-CoV-2 spleen the Coronaviridae therapeutic targets Togaviridae Viral macrodomain Virus Disease were used X domain [DOI] 10.1098/rsob.200237 PMC 바로가기 [Article Type] 201