Proteomic profiling of the monothiol glutaredoxin Grx3 reveals its global role in the regulation of iron dependent processes모노티올 글루타레독신 Grx3의 단백질체 프로파일링은 철 의존적 과정의 조절에서 그것의 전체적인 역할을 보여줍니다Research Article Published on 2020-06-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affinity purification amplify applied approach associations biological processes Candida albican Candida albicans Cell cellular processes cofactor commensal component conserved Critical cytosolic determine DNA essential nutrient expression function functions fungal Gene Expression genotoxic glutaredoxin growth Grxs Heat shock histidine homeostasis Host human host humans in vivo interact iron iron homeostasis leucine maintain mass spectrometry metabolism mutant organism Organisms oxidative oxygen pathogen Pathogens performed Protein protein translation proteomic regulate Regulation regulatory circuit repair repression required respond reveal sulfur Support survival Taking target gene Target genes the cell Tryptophan utilization virulence [DOI] 10.1371/journal.pgen.1008881 PMC 바로가기 [Article Type] Research Article
A novel magnetic beads-based method for polioviral concentration from environmental samplesarticle Published on 2018-10-312024-09-01 Journal: Journal of Virological Methods [Category] 폴리오, [키워드] Affinity purification antibodies CD155 Environmental surveillance Key words Phagemids Poliovirus [Article Type] article
Wor1 establishes opaque cell fate through inhibition of the general co-repressor Tup1 in Candida albicansWor1은 Candida albicans에서 일반적인 공동 억제 인자 Tup1의 억제를 통해 불투명한 세포 운명을 설정합니다.Research Article Published on 2018-01-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence Affect Affinity purification analyses Analysis approach Author bypass Candida Candida albican Candida albicans carbon carbon source carbon sources Cell cell fate cells colonization colonize commensal complex protein explain expressed facilitate Factor function functions fungal Genetic gut microbiota Host identify individuals induce Loss maintain mass spectrometry mass spectroscopy master regulator mechanism molecular Morphological occur pathogen pathogenic phenotypic plasticity positive feedback promoter Proteins provide Region regulated Regulation regulatory circuit repression repressor serious infection serious infections stability starting switching temperature transcriptional transcriptional repressor undergo white Wor1 [DOI] 10.1371/journal.pgen.1007176 PMC 바로가기 [Article Type] Research Article
PKA activity is essential for relieving the suppression of hyphal growth and appressorium formation by MoSfl1 in Magnaporthe oryzaePKA 활성은 Magnaporthe oryzae에서 MoSfl1에 의한 균사 성장 및 부착기 형성 억제를 완화하는 데 필수적입니다.Research Article Published on 2017-08-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation affinity Affinity purification Author C-terminal CAMP catalytic subunit cellular processe characterized co-IP conidia conidiation conserved Critical Deletion downstream eukaryotic cell eukaryotic cells Extracellular function functional functions Fusarium growth growth defect hyphal Infection insertion Interaction invasive involved IP assays loss-of-function mutation loss-of-function mutations Magnaporthe mutant mutants Mutation overlapping Pathogenesis pathway penetration Phosphorylation PKA produced purification reduced regulate regulated repressor residue response signaling pathway significantly strain Strains suppress suppressed suppression suppressor suppressors transcription factor transcriptional Treatment was reduced yeast [DOI] 10.1371/journal.pgen.1006954 PMC 바로가기 [Article Type] Research Article
Disrupting the cortical actin cytoskeleton points to two distinct mechanisms of yeast [ PSI + ] prion formation피질의 액틴 세포골격을 교란하는 것은 효모 [PSI + ] 프리온 형성의 두 가지 뚜렷한 메커니즘을 나타냅니다.Research Article Published on 2017-04-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogate abrogated Actin affected Affinity purification aggregate aggregates aggregation Analysis antioxidant component composed conditions cortical Deletion disease disrupt examined form forms fragmentation Frequency fungal identify implicated increase infectious agent infectious agents insoluble protein mass spectrometry mechanism misfolded protein misfolded proteins molecular MOST mutant mutants neurodegenerative occur overexpression oxidative oxidative damage oxidative stress oxidized Prevent Previous studies previous study prion Probability Protein Protein misfolding Proteins PSI reduced required thought transition translation Trigger undergo yeast yeast cell yeast cells [DOI] 10.1371/journal.pgen.1006708 PMC 바로가기 [Article Type] Research Article
PRO40 Is a Scaffold Protein of the Cell Wall Integrity Pathway, Linking the MAP Kinase Module to the Upstream Activator Protein Kinase CPRO40은 MAP 키나제 모듈을 업스트림 활성제 단백질 키나제 C에 연결하는 세포벽 무결성 경로의 스캐폴드 단백질입니다.Research Article Published on 2014-09-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activator adapter adapters Affinity purification Alzheimer's disease approach ascomycete asexual development bind Cancer Cell cell differentiation Cell fusion cell wall characterized combating conserved Control deletion mutant deletion mutants determinant developmental developmental processe developmental processes disease domain ENCODE environmental cue environmental cues eukaryote eukaryotes eukaryotic Evidence experiment Extensive filamentous fungi fruiting bodies fungal fungi fungus Genetic growth homolog implicated integrity Interaction interaction partner involved kinase MAPK mass spectrometry mitogen mitogen-activated protein kinase module molecular MOST mutant mutated N-terminal Pathogenesis pathogenicity pathway Pathways Phosphorylation polar Protein protein kinase protein kinase C Regulation required scaffold protein Signal transduction Signaling Sordaria macrospora Stress stress response symbiosis the cell upstream vegetative growth wall yeast [DOI] 10.1371/journal.pgen.1004582 PMC 바로가기 [Article Type] Research Article