Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestriesOAS1 넌센스 매개 부패의 유전적 조절은 유럽 및 아프리카 혈통의 환자에서 COVID-19 입원과의 연관성을 뒷받침합니다Article Published on 2022-08-012022-09-11 Journal: Nature Genetics [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, 치료기술, 치료법, [키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African allele Analysis Antiviral association Bioinformatic clearance clinical trial contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity decrease disease early treatment European exonic expression functional Genetic genetic regulation Haplotype Hospitalization Hospitalized in vitro study interferon interferons locus mitigate molecular mechanism molecular mechanisms OAS1 Patient Protein reduced Regulation risk SARS-CoV-2 SARS-CoV-2 clearance severe COVID-19 splicing susceptibility variant with COVID-19 [DOI] 10.1038/s41588-022-01113-z PMC 바로가기 [Article Type] Article
APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patientsAPOE는 ACE2와 상호작용하여 COVID-19 환자에서 SARS-CoV-2 세포 진입 및 염증을 억제합니다Article Published on 2022-08-012022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 치료기술, 치료법, [키워드] ACE2 addition Affect allele ApoE APOE4 Apolipoprotein Apolipoprotein e assays binding binding affinity cardiovascular diseases carrier carriers cells cellular entry chemokine cholesterol cholesterol metabolism clinically comparable Concentration COVID-19 infection COVID-19 patient COVID-19 patients disease severity docking domain elevated explain genetic risk factor Infection Inflammation Inflammatory factor inhibit inhibiting interact Interaction isoform Lipid mechanism metabolism Protein receptor reduce Regulatory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike protein serum serum concentrations spike Spike protein susceptibility the SARS-CoV-2 transmission electron microscopy viral entry viruses Zinc [DOI] 10.1038/s41392-022-01118-4 PMC 바로가기 [Article Type] Article
FURIN gene variants (rs6224/rs4702) as potential markers of death and cardiovascular traits in severe COVID-19심각한 COVID-19에서 사망 및 심혈관 특성의 잠재적 마커로서의 FURIN 유전자 변이체(rs6224/rs4702)Article Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] addition age allele association candidate Candidates cleaving COVID-19 COVID-19 patient COVID-19 patients death death case diabetes DNA variant DNA variants evaluated expression functional furin FURIN gene gene polymorphism Genotype genotyped Haplotype Homozygosis hypercholesterolemia hypercholesterolemia. hyperlipidaemia hypertension increased risk independent risk factor independent risk factors Infection infection cycle intensive care intensive care unit Logistic regression marker multiple logistic regression Odds ratio physiological protease regulate risk risk of death SARS-CoV-2 severe COVID-19 significantly significantly increased statistically susceptibility traits variant Viral protein Viral proteins virus [DOI] 10.1002/jmv.27748 PMC 바로가기 [Article Type] Article
Rapid displacement of SARS-CoV-2 variant Delta by Omicron revealed by allele-specific PCR in wastewater폐수에서 대립 유전자 특이적 PCR로 밝혀진 Omicron에 의한 SARS-CoV-2 변이형 Delta의 빠른 변위Article Published on 2022-08-012022-09-11 Journal: Water research [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Accuracy allele Alpha B.1.1.529 Clinical studies clinical study Community complement Concentration COVID-19 Delta delta variant demonstrated detect distribution Health immune evasion Infection influent Italy mapped measure Mutation omicron Omicron variant PCR Public health responses qPCR Quantitative Rapid report RNA concentrations RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant SARS-CoV-2 variants Support Surveillance target These data Transmissibility Treatment triggered utility vaccination rates Vaccine breakthrough variant variant frequencies variant frequency VoC wastewater [DOI] 10.1016/j.watres.2022.118809 PMC 바로가기 [Article Type] Article
Heterogeneity in IgG-CD16 signaling in infectious disease outcomesArticle Published on 2022-08-012022-11-15 Journal: Immunological reviews [Category] 진단, [키워드] acute infections allele binding contribute coronavirus disease COVID-19 dengue disease disease downstream driven by effector functions. expression Fc afucosylation form functions glycosylation heterogeneity IgG IgG antibody IgG1 IgG1 antibodies immune complex Immune homeostasis Infection Infectious disease Inflammation Inflammatory response inflammatory signaling ligands mechanism modulate outcome Pathogenesis pathogenic required Signaling viral infection while [DOI] 10.1111/imr.13109 PMC 바로가기
Multiplex Fragment Analysis for Flexible Detection of All SARS-CoV-2 Variants of Concern우려되는 모든 SARS-CoV-2 변이체의 유연한 검출을 위한 다중 단편 분석Article Published on 2022-07-272022-09-11 Journal: Clinical Chemistry [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] ABI Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus allele Analysis analyzed approach capillary electrophoresis concern coronavirus cycle threshold deleted Deletion Delta detection effective equipment exhibited fluorescent fragment insertion insertions Lambda limit of detection multiplex mutants omicron ORF1a ORF8 PCR performed primer primer pair primer pairs RDR RDR1 RDR2 RDR3 Receptor binding domain resolved respiratory specimens S-gene SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specificity subsequent target variant variants variants of concern VoC VOCs WGS whole genome Whole genome sequencing [DOI] 10.1093/clinchem/hvac081 PMC 바로가기 [Article Type] Article
Covariance predicts conserved protein residue interactions important for the emergence and continued evolution of SARS-CoV-2 as a human pathogen공분산은 인간 병원체로서 SARS-CoV-2의 출현과 지속적인 진화에 중요한 보존된 단백질 잔기 상호작용을 예측합니다Article Published on 2022-07-272022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] allele alleles Amino acid amino acid residue amino acid residues Analysis approach caused change Combination comprehensive analysis conserved coronavirus CoV CoV genome covariance CoVs difference dominant Epidemics Evolution Evolution of SARS-CoV-2 exhibited followed by Frequency Genome host adaptation human pathogen implicated incrementally independent Interaction Lineage lineages nucleotide occurred Pandemics Pathogens predict Protein protein sequence Region reservoirs residue SARS-CoV-2 SARS-CoV-2 variants statistically unique Viral protein Viral proteins β-coronavirus β-Coronaviruses [DOI] 10.1371/journal.pone.0270276 PMC 바로가기 [Article Type] Article
Real-time allelic assays of SARS-CoV-2 variants to enhance sewage surveillance하수 감시를 강화하기 위한 SARS-CoV-2 변이체의 실시간 대립유전자 분석Article Published on 2022-07-152022-09-11 Journal: Water research [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] allele Allele-specific RT-qPCR allelic Alpha Analysis Beta Beta variant clinically Community sewage Concordance COVID-19 patient cross-reactivity Delta delta variant diagnosed discharged eight ENhance Gamma genotypes Hong Kong integration Lambda offer omicron Omicron variant outbreak provided qPCR quarantine real-time RT-qPCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity sequence sewage Sewage surveillance specificity Surveillance variant variants Viral RNA whole-genome sequencing [DOI] 10.1016/j.watres.2022.118686 PMC 바로가기 [Article Type] Article
Novel Lateral Flow-Based Assay for Simple and Visual Detection of SARS-CoV-2 MutationsSARS-CoV-2 돌연변이의 간단하고 시각적인 검출을 위한 새로운 측면 흐름 기반 분석Article Published on 2022-07-142022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] allele amplification asymmetric comparable cycle threshold demonstrated detect detection DNA DNA microarray E484K feature identification impacted Increases K417N L452R Lateral lateral flow lateral flow strip lateral flow strip (LFS) limitations marker molecular molecular diagnostic multiplex Mutation mutations N501Y novel Public health responses real time recommendation reference method Region RNA extract RNA extracts RT-PCR RT-qPCR SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 S gene SARS-CoV-2 variant SARS-CoV-2 variants simple spike mutation spike mutations Surveillance target variant variants of concern virus Visual Visual detection [DOI] 10.3389/fcimb.2022.902914 PMC 바로가기 [Article Type] Article
Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: A systematic review and meta-analysisCOVID-19 질병 및 중증도에 대한 감수성과 관련된 유전적 다형성: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-07-062022-09-11 Journal: PLoS ONE [Category] 변종, [키워드] 95% CI ACE1 advanced age allele alleles analyzed ApoE article association C allele calculated candidate gene CCR5 clinical symptom Clinical symptoms Comorbidities contribute COVID-19 COVID-19 disease COVID-19 infection COVID-19 pathogenesis COVID-19 severity disease eligible fixed form forms Genetic polymorphism genetic polymorphisms Genetic variant genetic variants GWAS HLA HLA-A HLA-B HLA-C identify investigated involved loci Meta-analysis polymorphism Polymorphisms presence of comorbidity random Repository risk searched severe forms of COVID-19 severity of COVID-19 significantly Stata software suggested susceptibility systematic review the disease TMPRSS2 Variation [DOI] 10.1371/journal.pone.0270627 PMC 바로가기 [Article Type] Meta-Analysis