alveolar epithelium – Page 2 – Communicable Diseases Research

A model of the innate immune response to SARS-CoV-2 in the alveolar epithelium

Mathematics

Published on 2021-08-112022-10-28
Journal: Royal Society Open Science [Category] COVID-19,

Double-blind, Randomized, Placebo-controlled Trial With N-acetylcysteine for Treatment of Severe Acute Respiratory Syndrome Caused by Coronavirus Disease 2019 (COVID-19)

Randomized Controlled Trial

Published on 2021-06-012022-10-04
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상,

[키워드] acute respiratory syndrome administration Admission age alveolar epithelium angiotensin angiotensin-converting enzyme 2 Apoptosis Brazil cells Characteristics Chest computed tomography clinical Comorbidities conducted coronavirus coronavirus disease COVID-19 Department determine disease severity double-blind Emergency Endotracheal intubation Endpoint enrolled Evolution Gas exchange group groups High dose homeostasis ICU inactivation increase in induce Inflammation intensive care Laboratory test Local mechanical ventilation Medicine Mortality NAC no significant difference not affect oxyhemoglobin saturation Patient patients with COVID-19 placebo-controlled Pneumonia primary endpoint Randomized receive Redox imbalance registry respiratory Respiratory failure respiratory rate SARS-CoV-2 secondary Secondary endpoints severe COVID-19 Sex single-center suppress the placebo group Trial
[DOI] 10.1093/cid/ciaa1443 PMC 바로가기 [Article Type] Randomized Controlled Trial

Molecular mechanisms of Na,K-ATPase dysregulation driving alveolar epithelial barrier failure in severe COVID-19

Editorial

Published on 2021-06-012023-06-16
Journal: American journal of physiology. Lung cellular and [Category] MERS, SARS,

[키워드] alveolar epithelium alveolar fluid clearance COVID-19 lung edema Na,K-ATPase SARS-CoV-2
[DOI] 10.1152/ajplung.00056.2021 PMC 바로가기 [Article Type] Editorial

Human-Based Advanced in vitro Approaches to Investigate Lung Fibrosis and Pulmonary Effects of COVID-19

Medicine

Published on 2021-05-072022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] in vitro lung models acute respiratory distress affected alveolar alveolar epithelium alveolar regeneration ARDS assumed cause caused causing classical clinically collagen coronavirus coronavirus disease COVID-19 current DAD Diffuse alveolar damage disease ECM Effect Evidence Extracellular matrix fatal disease fibroblast in vitro in vitro model in vivo induce interstitial interstitial pulmonary fibrosis IPF knowledge lung Lung diseases Lung fibrosis lung organoids lung-on-chip mechanical stress molecular mechanism multicellular organoids Oxygenation pandemic Pathogenesis pathophysiological patients precision-cut lung slices proliferation Proteins pulmonary pulmonary fibrosis pulmonary impairment Pulmonary infection reduced respiratory SARS-CoV-2 SARS-COV-2 infection Symptoms syndrome tissue tissue regeneration treatment strategy Vaccine viral infections wound healing
[DOI] 10.3389/fmed.2021.644678 PMC 바로가기 [Article Type] Medicine

Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signatures

SARS-CoV-2 및 H1N1 폐 손상의 공간 매핑은 차등 전사 서명을 식별합니다

Report

Published on 2021-03-232022-09-10
Journal: Cell Reports Medicine [Category] MERS, SARS, 신종인플루엔자, 유전자 메커니즘, 진단,

[키워드] Abstract acute respiratory distress acute respiratory distress syndrome alveolar epithelium anti-viral response anti-viral responses antiviral response ARDS Autopsy both viruses cellular change Coagulopathy COVID-19 demonstrated double infection dual enhanced Extracellular gene signature H1N1 H1N1 influenza identify induced genes infected individual Influenza Injury leads lung Lung injury lung tissue Macrophage macrophage activation macrophages pathway patients with SARS-CoV-2 phenotype platform Post-mortem Region remodeling respiratory distress response SARS-CoV-2 SARS-CoV-2 ARDS SARS-COV-2 infection SARS-CoV-2 infections severe SARS skewed spatial transcriptomics squamous metaplasia syndrome therapeutic target therapeutic targets tissue tissue remodeling transcriptional transcriptional change Transcriptome transcriptomic Type II pneumocyte type II pneumocytes unique Vascular injury vascular tissue Viral viral infections
[DOI] 10.1016/j.xcrm.2021.100242 PMC 바로가기 [Article Type] Report

Immunogenicity and protective efficacy of inactivated SARS-CoV-2 vaccine candidate, BBV152 in rhesus macaques

Article

Published on 2021-03-022022-10-29
Journal: Nature Communications [Category] COVID-19, SARS,

[키워드] Administered affected alveolar epithelium Bronchoalveolar lavage fluid Candidates clearance clinical development clinical trial COVID-19 pandemic days post-infection develop effective vaccine Efficacy exhibited FIVE four group groups Health histopathological IgG immunized immunogenicity immunohistochemistry inactivated Inactivated Vaccines India interstitial pneumonia lung tissue macaque Macrophage nasal swab Neutralizing antibody titer no evidence of overcome pandemic phase Placebo Pneumonia Preclinical research Protective public health rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 vaccine second dose the placebo group the vaccine three group throat swab Vaccine vaccine candidate Viral antigen viral infection
[DOI] 10.1038/s41467-021-21639-w PMC 바로가기 [Article Type] Article

Predictive effects of IgA and IgG combination to assess pulmonary exudation progression in COVID-19 patients

COVID-19 환자의 폐삼출 진행을 평가하기 위한 IgA 및 IgG 조합의 예측 효과

Article

Published on 2021-03-012022-09-11
Journal: Journal of medical virology [Category] SARS, 진단, 치료기술,

[키워드] Admission alveolar epithelium Analysis average biopsy blood gas blood gas analysis chemiluminescence Cohort Combination correlated COVID-19 COVID-19 patient COVID-19 patients Defense destruction Deterioration edematous Effect Effects enlargement epithelium feces gas analysis highest Hospital admission Hypoxemia hypoxia IgA IgA level IgA levels IgG IgG level IgG levels Immunoglobulin immunoglobulin A Invasion lung moving average mucosa oxygen oxygenation index positive rate predict prediction effects. progression pulmonary lesion pulmonary lesions SARS-CoV-2 serum severe COVID-19 patients sputum Viral viral RNA detection was tested was used
[DOI] 10.1002/jmv.26437 PMC 바로가기 [Article Type] Article

Molecular Mechanisms of Vascular Damage During Lung Injury

폐 손상 중 혈관 손상의 분자 메커니즘

Review

Published on 2021-01-012022-09-11
Journal: Advances in experimental medicine and biology [Category] 유전자 메커니즘,

[키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome ADRS alveolar epithelium ARDS association behavioral risk factors change contribute COVID-19 Cytokines damage disease disease risk Disruption DNA DNA methylation endothelial activation Enzyme inhibitor Enzyme inhibitors Epigenetic epigenetics epithelial Epithelial barrier evaluate experimental model experimental models explained Factor focus Genetic genetic factors Genetic polymorphism genetic polymorphisms Genetic predisposition high mortality rate histone Histone acetylation, DNA methylation Hospitalization humans increased vascular permeability Inflammation Inflammatory response Injury intensive care lung endothelial Lung injury mechanism Modification molecular mechanism molecular mechanisms Mortality occur offer Pathogenesis phenotypic potential therapeutic target Prevent pro-inflammatory cytokines promote Research respiratory distress Respiratory distress syndrome Risk factors susceptibility syndrome systemic and local treat variety Vascular damage Vascular endothelium vascular permeability
[DOI] 10.1007/978-3-030-68748-9_6 PMC 바로가기 [Article Type] Review

Biomimetic Human Disease Model of SARS‐CoV‐2‐Induced Lung Injury and Immune Responses on Organ Chip System

Full Paper

Published on 2020-12-212022-10-28
Journal: Advanced Science [Category] COVID-19,

[키워드] accelerate activated acute respiratory syndrome alleviate alveolar alveolar epithelium Analysis cause caused cell types circulating coronavirus Coronavirus disease 2019 COVID‐19 COVID‐19 disease Disease model Drug testing Endothelium exacerbated exhibit feature global pandemic Human human disease Immune cell immune cell recruitment immune response in vitro Infection Inflammation Inflammatory cytokine inhibit Injury innate immune response involved Lung injury Model organ organ chip pathway platform provide Remdesivir Research response SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 susceptibility System unique viral infection viral replication virus
[DOI] 10.1002/advs.202002928 PMC 바로가기 [Article Type] Full Paper

A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection

상피와 내피 사이의 혼선은 SARS-CoV-2 감염 동안 인간의 폐포-모세혈관 손상을 중재합니다

Article

Published on 2020-12-082022-09-11
Journal: Cell Death & Disease [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료제,