Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cellsArticle Published on 2022-09-212022-11-15 Journal: eLife [Category] 바이오마커, 유전자 메커니즘, [키워드] alveolar alveolar epithelial cell alveolar epithelium alveolar regeneration Basal cell basal cells Biomarkers cause Cell Cell Biology Complete COVID-19 ectopic epithelial epithelial cell function IMPROVE increase independent Infection lineages lung lung parenchyma lung regeneration Lungs mechanism mice mouse mouse model Notch other organs proliferate promote promoted regenerative regenerative medicine regulate significantly stem cells suggested suppressed Tamoxifen tuft cell tuft cells viral infection Wnt [DOI] 10.7554/eLife.78217 PMC 바로가기
Targeting of Glycosaminoglycans in Genetic and Inflammatory Airway Disease유전 및 염증성 기도 질환에서 글리코사미노글리칸의 표적화Review Published on 2022-06-082022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, 진단, [키워드] addition airway alveolar epithelium Asthma Cell cell differentiation chronic obstructive chronic obstructive pulmonary disease contribute COVID-19 COVID-19 pandemic cystic fibrosis described Diseases ECM Endothelium Extracellular matrix fibrosis glycosaminoglycan glycosaminoglycans Immune cell infiltration Inflammation Inflammatory Interaction interstitial involved lung Migration molecular interaction pathology pathophysiological role pulmonary disease receptor Research Respiratory disease targeting therapeutic agents tissue wound healing [DOI] 10.3390/ijms23126400 PMC 바로가기 [Article Type] Review
Ultrastructural examination of lung “cryobiopsies” from a series of fatal COVID-19 cases hardly revealed infected cells일련의 치명적인 COVID-19 사례에서 폐 "냉동생검"의 미세구조 검사는 감염된 세포를 거의 드러내지 않음Article Published on 2022-05-012022-09-11 Journal: Virchows Archiv [Category] COVID19(2023년), SARS, 치료기술, [키워드] accumulation aggregates alveolar alveolar damage alveolar epithelium Analysis Autopsy caused Cell cell types cells coronavirus COVID-19 patient COVID-19 patients death Detachment diffuse Diffuse alveolar damage electron electron microscopy Endothelium erythrocytes Extracellular fatal COVID-19 FIBRIN fixation fixed granulocyte Histopathology hyaline membrane hyaline membranes hyperplasia immune impairment IMPROVE infected cell investigated latency leukocyte leukocytes lung lung damage macrophages mechanisms Microscopy neutrophilic Particle Patient Region Replication respiratory distress Respiratory distress syndrome Sample SARS‐CoV‐2 Stage Stress stress response the disease the patient these cell These cells Thin section thrombocyte Thrombocytes tissue Ultrastructural analysis ventilated patient ventilated patients virus Virus particle. [DOI] 10.1007/s00428-022-03308-5 PMC 바로가기 [Article Type] Article
Development of human-derived, three-dimensional respiratory epithelial tissue constructs with perfusable microvasculature on a high-throughput microfluidics screening platformArticle Published on 2022-02-142023-07-08 Journal: Biofabrication [Category] COVID19(2023년), [키워드] 3D in vitro model alveolar epithelium Barrier function high-throughput platform microfluidic perfusion small airway epithelium vascular network. [DOI] 10.1088/1758-5090/ac32a5 PMC 바로가기
Tissue-level alveolar epithelium model for recapitulating SARS-CoV-2 infection and cellular plasticitySARS-CoV-2 감염 및 세포 가소성을 요약하기 위한 조직 수준 폐포 상피 모델Article Published on 2022-01-192022-09-12 Journal: Communications Biology [Category] SARS, 진단, 치료제, [키워드] Activation alveolar alveolar cell alveolar epithelial cells alveolar epithelium Cell cells cellular clinically COVID-19 Culture cytokine production damaged exhibit feature IMPROVE Infection Injury mechanism media Pathogenesis plasticity Pneumonia Prevent primary cell pulmonary pulmonary fibrosis Research Respiratory system models SARS-COV-2 infection SARS-CoV-2 pseudovirus subsequent translational viral entry viral infection Wnt signaling [DOI] 10.1038/s42003-022-03026-3 PMC 바로가기 [Article Type] Article
GM-CSF: Orchestrating the Pulmonary Response to InfectionPharmacology Published on 2022-01-172022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome alveolar alveolar epithelium alveolar macrophage conditions coronavirus coronavirus disease COVID-19 Critical epithelial cell type GM-CSF granulocyte-macrophage colony-stimulating factor help homeostasis immune response immune system Infection Infectious disease lung Macrophage maintain pathologic physiological condition preclinical data pulmonary pulmonary infectious diseases respiratory infections respond response sargramostim SARS-CoV-2 Spread subsequent syndrome treatment for COVID-19 [DOI] 10.3389/fphar.2021.735443 PMC 바로가기 [Article Type] Pharmacology
Endothelial Dysfunction through Oxidatively Generated Epigenetic Mark in Respiratory Viral InfectionsReview Published on 2021-11-072022-10-31 Journal: Cells [Category] COVID-19, SARS, 신종인플루엔자, [키워드] addition alveolar epithelium antiviral drugs Blood blood flow changes in clinical care Control current Cytokines decrease disease distress edema effective Electrolytes endothelial endothelial cells Epigenetic fluids Gene Expression Growth factors host immune system immune cells implication Infection Influenza influenza H1N1 lack leukocyte macromolecule management MARK morbidity and mortality oxidative stress Oxygenation pathological change Patient pulmonary complications Pulmonary edema Pulmonary pathology regulate respiratory Respiratory distress syndrome Respiratory failure respiratory syncytial virus respiratory viral infection respiratory viral infections response risk RSV SARS-CoV-2 syndrome Treatment triggered Vascular Vascular endothelium viral genome viral infections [DOI] 10.3390/cells10113067 PMC 바로가기 [Article Type] Review
Serum Krebs von den Lungen-6 for Predicting the Severity of COVID-19 Lung Injury: A Systematic Review and Meta-AnalysisCovid-19 폐 손상의 중증도 예측을위한 혈청 Krebs von den Lungen-6 : 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-11-062022-08-31 Journal: Iranian Biomedical Journal [Category] MERS, 바이오마커, [키워드] 95% CI adult COVID-19 patients alveolar epithelium Analysis appear article Biomarker conducted COVID-19 COVID-19 patient COVID-19 patients eligibility criteria expressed glycoprotein Infectious disease Injury Krebs von den Lungen-6 library Lung injury NOS on type ProQuest reflected review screened sensitivity Sensitivity and specificity serum severe lung injury Severe patient severe patients severity significantly higher SMD specificity systematic review [DOI] 10.52547/ibj.25.6.381 PMC 바로가기 [Article Type] Meta-Analysis
Potential Therapeutic Applications of Pulmonary Surfactant Lipids in the Host Defence Against Respiratory Viral Infections호흡기 바이러스 감염에 대한 숙주 방어에서 폐 계면활성제 지질의 잠재적 치료 응용Review Published on 2021-09-272022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] Against alveolar alveolar epithelium Antiviral effect antiviral effects antiviral properties application ARDS breathing complex COVID-19 Defense facilitate Host host defense immune responses in some Inflammatory response Lipid lipids Lungs modify modulate phosphatidylglycerol phosphatidylinositol Potential promise Protein protein A Proteins pulmonary Pulmonary Surfactant pulmonary surfactant lipids reducing required respiratory respiratory viral infections shown surface tension surfactant tension therapeutic therapeutic applications Viral [DOI] 10.3389/fimmu.2021.730022 PMC 바로가기 [Article Type] Review
Ultra- and micro-structural changes of respiratory tracts in SARS-CoV-2 infected Syrian hamstersSARS-COV-2 감염 시리아 햄스터에서 호흡기의 초소형 및 미세 구조적 변화Research Article Published on 2021-09-162022-09-10 Journal: Veterinary Research [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alveolar alveolar epithelium alveoli animal models Bronchiole caused cellular change changes in Characteristics collected coronavirus cytoplasm cytoplasmic diminished disease electron eosinophil eosinophils epithelial euthanized groups hamster increasingly infancy inflammatory cell inflammatory cells information inoculated intranasally lamina propria lesion lesions Lower respiratory tract lung Lymphocytes macrophages margin Microscopic neutrophil Neutrophils nucleus on type organelle pandemic Particles pathological changes Post-infection pulmonary lesions PULMONARY VESSELS Research respiratory respiratory epithelium respiratory tract SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus susceptible therapy tissue tissues Trachea tracheal type 2 pneumocyte upper and lower respiratory tracts Vaccine vacuolation Vesicle vessels Viral virion [DOI] 10.1186/s13567-021-00988-w PMC 바로가기 [Article Type] Research Article