amino acid metabolism – Page 2 – Communicable Diseases Research

RS-5645 attenuates inflammatory cytokine storm induced by SARS-CoV-2 spike protein and LPS by modulating pulmonary microbiota

RS-5645는 폐 미생물총을 조절하여 SARS-CoV-2 스파이크 단백질 및 LPS에 의해 유도된 염증성 사이토카인 폭풍을 약화시킵니다

Research Paper

Published on 2021-07-252022-09-10
Journal: International Journal of Biological Sciences [Category] SARS, 바이오마커,

Elevation of Serum Cytokine Profiles and Liver Metabolomic Normalization in Early Convalescence of COVID-19 Patients

Medicine

Published on 2021-07-072022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] addition alanine aminotransferase amino acid metabolism association B-cell change clinical manifestation convalescence convalescent phase Coronavirus disease 2019 correlations COVID-19 COVID-19 patient cytokine cytokine profile Cytokines decrease demonstrated discharged patient elevated Elevation functions global public health hospital discharge IFN-γ IL-10 IL-2 IL-4 IL-6 immune implication Injury interferon-γ lipid metabolism liver Liver function Liver injury liver repair metabolomic metabolomic analysis metabolomics normalization performed physiological effect profile profiles Retrospective study returned SARS-CoV-2 serum cytokine significantly supported T-cell Treatment tumor necrosis factor-α UPLC/Q-TOF-MS viral replication
[DOI] 10.3389/fmed.2021.626633 PMC 바로가기 [Article Type] Medicine

Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19

메타게놈 분석, COVID-19 환자의 구강인두 미생물총 변화 밝혀

Article

Published on 2021-05-132022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 유전자 메커니즘, 임상, 치료기술, 치료제,

[키워드] Acinetobacter addition alteration Amino acid amino acid metabolism Analysis antimicrobial resistance AUC BALF Biomarker Biomarkers Characteristics characterized Classifier Co-infection correlated COVID-19 COVID-19 group COVID-19 patient COVID-19 patients COVID-19 severity critical cases Depletion disease severity elevated enrichment exhibited flu functional genus Health health problem healthy control healthy controls induce Infection Inflammatory response Influenza influenza B Klebsiella lung Lungs marker metabolism metagenomic sequencing microbe microbial Microbiology Microbiome microbiota natural reservoir neutrophil–lymphocyte ratio NLR Opportunistic Pathogens oral cavity Oropharyngeal oropharynx pathogen Pathogens Patient patients patients with COVID-19 resistance gene reveal severity significant enrichment significantly Streptococcus susceptibility swab specimen systemic inflammation with COVID-19
[DOI] 10.1038/s41392-021-00614-3 PMC 바로가기 [Article Type] Article

Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients

Article

Published on 2021-03-182022-10-29
Journal: Scientific Reports [Category] COVID-19,

The proteomic characteristics of airway mucus from critical ill COVID-19 patients

중증 코로나19 환자의 기도 점액 단백질 특성

Article

Published on 2021-03-152022-09-11
Journal: Life sciences [Category] 유전자 메커니즘,

[키워드] airway Airway mucus Amino acid amino acid metabolism Analysis beta-Alanine bronchoscopy cascades change Characteristics cholesterol cholesterol metabolism Coagulation complement coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical Critical ill patients cysteine Degradation down-regulated enrichment analysis expressed Fold change global public health Health crisis healthy controls isoleucine leucine lysosome metabolism methionine molecular target oxidative phosphorylation P-value pandemic Pathogenesis Pathways performed phagosome Protein proteomic Proteomic. quantified severe COVID-19 patients therapy Tryptophan up-regulated valine
[DOI] 10.1016/j.lfs.2021.119046 PMC 바로가기 [Article Type] Article

Identification and analysis of long non-coding RNAs and mRNAs in chicken macrophages infected with avian infectious bronchitis coronavirus

Research Article

Published on 2021-01-202022-10-28
Journal: BMC Genomics [Category] Coronavirus, MERS,

A Multi-Omics Study of Chicken Infected by Nephropathogenic Infectious Bronchitis Virus

Article

Published on 2019-11-162022-10-28
Journal: Viruses [Category] Coronavirus,

Interplay between mitochondria and diet mediates pathogen and stress resistance in Caenorhabditis elegans

미토콘드리아와 식단 사이의 상호 작용은 Caenorhabditis elegans에서 병원체와 스트레스 저항을 매개합니다

Research Article

Published on 2019-03-132022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Adults Affect alleviation Amino acid amino acid metabolism Anemia arise B12 bacterial pathogen Bacterial pathogenesis Bacterial pathogens biochemical Caenorhabditis canonical clearance cofactor condition Critical Defense deficiency demonstrated diet E . coli elegan elegans excess exhibited exposure to Genetic Health homeostasis Host host defense improvement Improvements Increasing independent independent of Interaction intermediate knockdown Laboratory Loss metabolism methylmalonyl-CoA microbiota mitochondrial mitochondrial dysfunction neurological defects organism overexpression pathogen pathogenic Pathogens Pathways phenotype physiological propionate RNAi-mediated gene sensitivity Stress Support survival susceptibility variety vitamin B12 vitamin B12 deficiency were used worm worms
[DOI] 10.1371/journal.pgen.1008011 PMC 바로가기 [Article Type] Research Article

Differences in the intestinal microbiota between uninfected piglets and piglets infected with porcine epidemic diarrhea virus

Research Article

Published on 2018-02-152022-10-28
Journal: PLoS ONE [Category] Coronavirus, MERS,

Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States

미국 내 다양한 민족의 여러 인구에서 심혈관 질환 및 제2형 당뇨병에 대한 공유 유전 조절 네트워크

Research Article

Published on 2017-09-282022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activity African Americans alterations American Americans Amino acid amino acid metabolism amino acids biological processe biological processes branched-chain amino acids cardiovascular cardiovascular disease cardiovascular diseases cause causes CAV1 Cell culture co-expression Cohort commonality complex disease connection Critical CVD data-driven death diabetes disease Diseases Diversity driven by driver ENCODE Epidemics eQTLs expression expression quantitative trait loci Extracellular matrix finding FIVE functional Functional genomics gene knockout gene network gene networks Genetic genetic risk Genome-wide association study Glucose graphical models GWAS GWAS hit help Hispanic HMGCR human population human populations hybrid identify IGF1 immune response in vitro in vivo information Integrative analysis knockdown lipids loci mechanism metabolism molecular molecular network mouse Mouse models multidimensional multiple tissues network models neuronal offer overlapping Panel Pathogenesis pathogenic pathogenic processe pathway Pathways PCOLCE Population populations Quantitative Regulatory regulatory network Risk factors shared pathway shared pathways siRNA Strains Support T2D the United State therapeutic therapeutic target tissues type 2 diabete type 2 diabetes
[DOI] 10.1371/journal.pgen.1007040 PMC 바로가기 [Article Type] Research Article