Hormonal intervention for the treatment of veterans with COVID-19 requiring hospitalization (HITCH): a multicenter, phase 2 randomized controlled trial of best supportive care vs best supportive care plus degarelix: study protocol for a randomized controlled trial입원이 필요한 COVID-19 참전 용사 치료를 위한 호르몬 개입(HITCH): 최상의 지지 요법 대 최상의 지지 요법과 데가렐릭스의 다기관, 2상 무작위 대조 시험: 무작위 대조 시험을 위한 연구 프로토콜Study Protocol Published on 2021-07-052022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] addition age Analysis androgen Androgen receptor Androgen suppression Anti-androgen anti-viral antibody approved association best Cell Chain Reaction Clinical improvement Clinical outcome clinical outcomes clinical trial Comorbidity coronavirus COVID-19 COVID-19 illness COVID-19 infection COVID-19 severity Cytokines degarelix determine double-blind Efficacy Exploratory analyses expression Factor FDA Hormone therapy Hospitalization Hospitalized host cell host cell surface Human hypertension IMPROVE include infection with SARS-CoV-2 Intervention Invasive mechanical ventilation investigated LHRH lung epithelium Luteinizing Hormone male mechanical ventilation Mortality multicenter Nasopharyngeal swab normal temperature outcome Patient patients hospitalized performed Phase 2 Placebo placebo-controlled polymerase chain polymerase chain reaction positive positive reverse transcriptase polymerase chain reaction primary endpoint Prostate cancer protease randomization Randomized Randomized controlled trial receptor signaling reduce required reverse transcriptase SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 entry secondary endpoint severity severity of COVID-19 severity of illness single dose stratified Study protocol supportive care suppress symptom severity target tissue temperature therapeutic targeting therapy TMPRSS2 TMPRSS2 expression transcriptase Treatment Trial Trial registration veteran Viral Viral load with COVID-19 [DOI] 10.1186/s13063-021-05389-0 PMC 바로가기 [Article Type] Study Protocol
Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes성 불일치 COVID-19 결과에 대한 영향과 함께 폐 AR, TMPRSS2 및 ACE2의 안드로겐 조절Article Published on 2021-05-272022-09-10 Journal: Scientific Reports [Category] 유전자 메커니즘, 진단, 치료기술, [키워드] ACE2 ACE2 expression administration androgen Androgen receptor androgens anti-androgens changes in clinical trial COVID-19 decrease enzalutamide Evidence expression female females Human Hypothesis implication independent independent of investigated lung Lungs male males mechanism mice Modification outcome Prostate cancer receptor receptor antagonist Regulation severity Sex Sex difference Steroid hormones Steroids subject susceptibility therapy tissue TMPRSS2 TMPRSS2 expression Treatment Viral viral entry [DOI] 10.1038/s41598-021-90491-1 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Viral Entry Proteins in Hyperandrogenemic Female Mice: Implications for Women with PCOS and COVID-19안드로겐과다증 암컷 마우스의 SARS-CoV-2 바이러스 진입 단백질: PCOS 및 COVID-19가 있는 여성에게 미치는 영향Article Published on 2021-04-252022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] ACE2 ACE2 mRNA ACE2 protein ADAM ADAM17 Affect androgen Androgen receptor androgens angiotensin angiotensin I angiotensin I converting enzyme 2 Body body composition body weight Brain cardiometabolic cathepsin cathepsin L causative agent cecum characterized Comorbidities COVID-19 COVID-19 pathology determined by Dihydrotestosterone disorder downregulated dysfunction elevated ELISA Endocrine enzyme fasting fasting glucose fat furin Glucose heart highlight host cell host cells host proteases hyperandrogenism infect kidney lean mass lung male mass mice morphology Mortality mRNA multiple tissue multiple tissues obesity organ systems ovarian Ovary ovulatory pathology Patient Polycystic polycystic ovary Polycystic ovary syndrome priming protease proteases Tmprss2 Protein protein level protein levels qPCR quantified receptor regulate renal risk risk factor Risk factors RT-qPCR SARS-CoV-2 SARS-CoV-2 entry serum severe COVID-19 severity small intestine tissues TMPRSS2 TMPRSS4 treated Treatment upregulated Urine was determined was measured Western-blot with COVID-19 women [DOI] 10.3390/ijms22094472 PMC 바로가기 [Article Type] Article
COVIDENZA – A prospective, multicenter, randomized PHASE II clinical trial of enzalutamide treatment to decrease the morbidity in patients with Corona virus disease 2019 (COVID-19): a structured summary of a study protocol for a randomised controlled trialCOVIDENZA - 코로나 바이러스 질병 2019(COVID-19) 환자의 이환율을 감소시키기 위한 엔잘루타미드 치료의 전향적, 다기관, 무작위 PHASE II 임상 시험: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-03-162022-09-10 Journal: Trials [Category] SARS, 임상, 치료제, [키워드] 7-point ordinal scale age androgen Androgen receptor androgen signalling antiandrogen anticipated approved Blinding Breast cancer breast-feeding cardiovascular disease center clinical trial comparator comparator Patients Complete connection Corona virus COVID-19 COVID-19 patient COVID-19 symptom COVID-19 symptoms decrease discharge disease dissemination element enzalutamide enzyme evaluate exclusion criteria expression FIVE focus followed by for inclusion hospital hospitalised host cell Hypothesis Identifier identify immunosuppressive drugs IMPROVE include Inclusion independent intensive care interim analysis Laboratory Major majority male mechanical ventilation men morbidity multicenter multicentre North number objective observation Open-label open-label trial Ordinal Scale outcome participant Participants Patient PCR Placebo power pregnant women primary endpoint primary endpoints PROC Prostate protocol randomisation list randomised randomised controlled trial Randomized receptor Region Registered Sample size SARS-CoV-2 host cell SAS Institute SAS version 9.4 Sex Standard of care status stratified Study protocol subject supplementary material symptomatic Testosterone TMPRSS2 to define treated Treatment treatment arm Trial university Västerbotten website with COVID-19 women [DOI] 10.1186/s13063-021-05137-4 PMC 바로가기 [Article Type] Letter
Proxalutamide Significantly Accelerates Viral Clearance and Reduces Time to Clinical Remission in Patients with Mild to Moderate COVID-19: Results from a Randomized, Double-Blinded, Placebo-Controlled TrialInfectious Disease Published on 2021-02-222022-10-31 Journal: Cureus [Category] COVID-19, [키워드] accelerated acute respiratory syndrome affected AGA Androgen receptor androgenetic alopecia anti-androgen therapy average clinical coronavirus COVID-19 Day defined dependent on double-blinded drugs expressed female female subject inhibitor less men Mild moderate Moderate COVID-19 Modification Patient patients treated Placebo positive proxalutamide Randomized receptor recruited reduced regulated Remission reported Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test severe coronavirus disease significantly subject subjects the placebo group time TMPRSS2 transmembrane transmembrane protease serine 2 treated Treatment Type II pneumocyte viral clearance viral spike protein [DOI] 10.7759/cureus.13492 PMC 바로가기 [Article Type] Infectious Disease
Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2530 Published on 2021-01-052022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome affected age androgen Androgen receptor androgen signaling angiotensin-converting enzyme 2 antagonist approved BET BET inhibitors Cell cells characterized clinical development Cohort coronavirus COVID-19 COVID-19 pandemic Critical domain effective elevated epidemiological expression Factor female greater Host host protein in vitro indication inhibited inhibitor Lung epithelial cells male morbidity Mortality New Prevent prevention of COVID-19 Prostate Prostate cancer protease Protective Protein receptor regulate replicate responsible Result SARS-CoV-2 SARS-CoV-2 entry factor SARS-COV-2 infection serine 2 Sex hormones Significance smoking subset suggested Support Supporting targeting therapeutic target TMPRSS2 transcriptional transcriptional regulation transmembrane Treatment viable treatment virus [DOI] 10.1073/pnas.2021450118 PMC 바로가기 [Article Type] 530
Management of prostate cancer radiotherapy during the COVID-19 pandemic: A necessary paradigm change코로나19 팬데믹(세계적 대유행) 중 전립선암 방사선 치료의 관리: 필요한 패러다임의 변화Review Published on 2021-01-012022-09-11 Journal: Cancer treatment and research communications [Category] 바이오마커, [키워드] Active surveillance active treatment androgen Androgen receptor can not COVID-19 COVID-19 pandemic Deprivation doubling European fraction group initiated Life expectancy Local local treatment Lymph node malignancy management Metastasis metastatic disease moderate Non-invasive offered pandemic Patient patients positive Prognosis Prostate Prostate cancer Radiation Oncology Radiotherapy recommendation reducing regimen required risk therapy Treatment Tumor Urology virus Volume worsening [DOI] 10.1016/j.ctarc.2021.100331 PMC 바로가기 [Article Type] Review
Androgenetic alopecia may be associated with weaker COVID-19 T-cell immune response: An insight into a potential COVID-19 vaccine boosterComment Published on 2021-01-012023-07-11 Journal: Med Hypotheses [Category] SARS, [키워드] Androgen receptor androgenetic alopecia COVID-19 Gabrin sign SARS-CoV-2 Vaccine [DOI] 10.1016/j.mehy.2020.110439 PMC 바로가기 [Article Type] Comment
Androgen receptor genetic variant predicts COVID-19 disease severity: a prospective longitudinal study of hospitalized COVID-19 male patients안드로겐 수용체 유전자 변이가 COVID-19 질병 중증도를 예측합니다: 입원한 COVID-19 남성 환자에 대한 전향적 종단 연구Article Published on 2021-01-012022-09-11 Journal: Journal of the European Academy of Dermatology and [Category] SARS, 변종, [키워드] Androgen receptor COVID-19 disease Genetic variant hospitalized COVID-19 male Patient predict [DOI] 10.1111/jdv.16956 PMC 바로가기 [Article Type] Article
Clinical stage molecule PT150 is a modulator of glucocorticoid and androgen receptors with antiviral activity against SARS-CoV-2임상 단계 분자 PT150은 SARS-CoV-2에 대한 항바이러스 활성이 있는 글루코코르티코이드 및 안드로겐 수용체의 조절제입니다.Article Published on 2020-12-012022-09-11 Journal: Cell cycle (Georgetown, Tex.) [Category] SARS, 치료제, [키워드] ACE2 activity androgen Androgen receptor Anti-SARS-CoV-2 Activity antidepressant Antiviral antiviral activities antiviral activity Cell cellular clinical clinical trial Concentration cortisol COVID-19 COVID-19 progression downregulation effective epithelial lining glucocorticoid Glucocorticoid antagonist Glucocorticoid receptor glucocorticoid receptor (GR immunomodulatory effect IND inhibitory member modulating modulation molecules Phase 1 Phase 2 phase 2 clinical trials platform predominant PT150 receptor safety profile SARS-CoV-2 suggested tested therapeutic TMPRSS2 TMPRSS2 expression variety virus [DOI] 10.1080/15384101.2020.1859752 PMC 바로가기 [Article Type] Article