Comparative 6-Month Wild-Type and Delta-Variant Antibody Levels and Surrogate Neutralization for Adults Vaccinated with BNT162b2 versus mRNA-1273BNT162b2 대 mRNA-1273 백신 접종을 받은 성인의 6개월 야생형 및 델타 변이체 항체 수준 및 대리 중화 비교Observational Study Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] ACE-2 age angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody Antibody concentrations Antibody Response binding blood sample BNT162b2 BNT162b2 vaccine Comparative comparison Concentration COVID-19 Delta delta variant demonstrated dose Effectiveness Efficacy FIVE Humoral immunity humoral immunogenicity IgG antibody individual less Level Lineage lineages Mann-Whitney U test mRNA mRNA vaccine mRNA vaccines mRNA-1273 mRNA-1273 vaccine mRNA-1273 vaccines outcome participant prospective observational cohort provided RBD Receptor binding domain Result SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines secondary outcome Secondary outcomes serological marker significantly higher spike spike IgG Spike protein Spike proteins surrogate tested type strain vaccine dose vaccinees Vaccines while wild-type wild-type strain [DOI] 10.1128/spectrum.02702-21 PMC 바로가기 [Article Type] Observational Study
Quantitative analysis of mRNA-1273 COVID-19 vaccination response in immunocompromised adult hematology patientsClinical Trial Published on 2022-03-082022-10-04 Journal: Blood advances [Category] SARS, 임상, [키워드] Allogeneic Analysis antibody Antibody concentrations Antigen autologous benefit binding antibody unit Cell cell transplantation Chemotherapy chimeric antigen receptor CLL Concentration COVID-19 vaccination disease HCT hematological hematology high risk High-dose identify IgG IgG4 Immunocompromised Immunoglobulin Immunosuppressant in healthy individuals leukemia lymphoma mRNA-1273 Multiple myeloma myeloid malignancies Netherland Obtaining Patient patients patients treated precluded predicted quantified recipient Registered response S1 IgG serum severe COVID-19 subunit T-cell therapy Treatment Trial vaccination Virus neutralization [DOI] 10.1182/bloodadvances.2021006917 PMC 바로가기 [Article Type] Clinical Trial
Trajectories of humoral and cellular immunity and responses to a third dose of mRNA vaccines against SARS-CoV-2 in patients with a history of anti-CD20 therapy항-CD20 치료 이력이 있는 환자에서 체액성 및 세포성 면역의 궤적과 SARS-CoV-2에 대한 3차 mRNA 백신에 대한 반응Article Published on 2022-03-012022-09-11 Journal: RMD Open [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] Analysis anti-CD20 anti-CD20 therapy anti-CD20 treatment anti-SARS-CoV-2 immune response anti-SARS-CoV-2 immune responses antibody concentration Antibody concentrations cell-mediated immune Cell-mediated immunity cellular immunity CMI comparable Concentration Control covariance COVID-19 decay dose elicited healthy volunteer healthy volunteers humoral humoral and cell-mediated immunity Humoral response humoral responses IgG immune responses Immunity immunogenicity inefficient interferon interferon-γ investigated Linear regression majority mRNA vaccine non-responder non-responders outcome Participants Patient patients registration number Responder responders response reveal rituximab RNA SARS-CoV-2 SARS-CoV-2 vaccine second vaccination systemic vasculitis Therapies therapy Trajectories trajectory Trial Registration Number vaccination Vaccination strategy Vaccine vaccine dose Vasculitis [DOI] 10.1136/rmdopen-2021-002166 PMC 바로가기 [Article Type] Article
Development of polypyrrole (nano)structures decorated with gold nanoparticles toward immunosensing for COVID-19 serological diagnosisResearch article Published on 2022-02-072022-10-05 Journal: Materials Today. Chemistry [Category] 치료기술, [키워드] acute respiratory syndrome anti-SARS-CoV-2 Antibody concentrations biosensor characterized clinical sample concerning contribute coronavirus COVID-19 Detection limit development Diagnosis electrical Gold nanoparticle Gold nanoparticles Human humans immunosensor Impedimetric biosensor infection control linear Microscopy MONITOR monoclonal antibodies monoclonal antibody morphology Polymer Polypyrrole modified electrode Polypyrrole nanotubes positive Protein reported SARS-CoV-2 Seroconversion serological serum was used [DOI] 10.1016/j.mtchem.2022.100817 [Article Type] Research article
Heterologous versus homologous COVID-19 booster vaccination in previous recipients of two doses of CoronaVac COVID-19 vaccine in Brazil (RHH-001): a phase 4, non-inferiority, single blind, randomised study브라질에서 코로나 박 코비드 -19 백신의 이전 수용자 (RHH-001)의 이전 수용자에서 이종과 동종 코비드 -19 부스터 백신 접종Clinical Trial Published on 2022-02-052022-08-13 Journal: Lancet (London, England) [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] 95% CI Ad26 Ad26.COV2-S Ad26.COV2-S vaccine Administered administration adverse events age All participant All participants anti-Spike IgG anti-spike IgG antibodies Anti-spike IgG antibody anti-spike IgG response Anti-spike IgG responses Antibody concentrations assigned AstraZeneca AZD1222 B.1.1.529 B.1.617.2 baseline binding blind BNT162b2 boost booster booster dose booster vaccination Booster vaccine Brazil ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine Concentration CoronaVac COVID-19 COVID-19 vaccine detectable discharged home dose eligible ENhance except for finding FIVE for inclusion four groups funding geometric geometric mean geometric mean ratio geometric mean ratios group Heterologous homologous homologous booster responses IgG antibody IgG responses immune response immune responses immunogenicity IMPROVE inactivated Infection inferiority janssen Live virus neutralising antibodies Local local and systemic reactogenicity profiles Ministry of Health mRNA vaccine Neutralising Antibodies neutralising antibody neutralising antibody titre neutralising antibody titres non-inferiority non-inferiority margin Older Older adults Omicron variant Omicron variants outcome participant Pfizer Pfizer–BioNTech phase 4 primary analysis Primary outcome profiles pseudovirus neutralising antibodies randomisation randomised Randomly reached recipient recombinant adenoviral vectored vaccine recombinant adenoviral-vectored ChAdOx1 nCoV-19 vaccine regimen Registered RHH-001 robust secondary Secondary outcomes Serious Adverse Events Seropositivity significant increase Sinovac stratified systemic reactogenicity the vaccine Vaccine vectored vaccine virus neutralising antibody whole-virion SARS-CoV-2 vaccine [DOI] 10.1016/S0140-6736(22)00094-0 PMC 바로가기 [Article Type] Clinical Trial
Maternal-neonatal transfer of SARS-CoV-2 immunoglobulin G antibodies among parturient women treated with BNT162b2 messenger RNA vaccine during pregnancy임신 중 BNT162b2 메신저 RNA 백신으로 치료받은 분만 여성에서 SARS-CoV-2 면역글로불린 G 항체의 산모-신생아 전이Article Published on 2022-01-012022-09-12 Journal: American journal of obstetrics & gynecology MFM [Category] SARS, 진단, [키워드] addition antibodies transfer antibody Antibody concentrations benefit Blood BNT162b2 breast milk Concentration conducted control group COVID-19 COVID-19 vaccine defined demonstrated determine Efficacy evaluate exclusion Humoral immunity Immunoglobulin initial interquartile range median Messenger RNA Neonatal neonatal immunity Neonates parturient Patient Placenta placental positive positive correlation Pregnancy pregnant women prospective cohort study raised recovered COVID-19 patient recovered patients SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody sera serum Serum level significantly higher the vaccine transfer treated vaccination Vaccine vaccine trial were measured women [DOI] 10.1016/j.ajogmf.2021.100492 PMC 바로가기 [Article Type] Article
Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD인플릭시맙은 IBD 환자에서 BNT162b2 및 ChAdOx1 nCoV-19 SARS-CoV-2 백신에 대한 면역원성 약화와 관련이 있습니다.Article Published on 2021-10-012022-09-12 Journal: Gut [Category] MERS, SARS, 진단, [키워드] 95% CI age anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody antibody concentration Antibody concentrations Antibody Response Autoimmune Autoimmune disease BNT162b2 BNT162b2 vaccine bowel ChAdOx1 ChAdOx1 nCoV-19 CLARITY Cohort Concentration concentrations COVID-19 cut-off defined Delayed disease dose Effectiveness Elecsy Evidence Fold change geometric mean IBD Immunity immunomodulator Infection Inflammatory Inflammatory bowel disease Inflammatory diseases infliximab investigated monoclonal antibody Multivariable models of BNT162b2 outcome Patient patients patients treated Primary outcome SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines second dose secondary Seroconversion seroconversion rate serological response single dose smoking TNF treated vaccination Vaccine Vaccines vedolizumab [DOI] 10.1136/gutjnl-2021-324789 PMC 바로가기 [Article Type] Article
Prevalence of SARS-CoV-2 IgG antibodies and their association with clinical symptoms of COVID-19 in Estonia (KoroSero-EST-1 study)SARS-CoV-2 IgG 항체의 유병률 및 에스토니아에서 COVID-19의 임상 증상과의 연관성(KoroSero-EST-1 연구)Article Published on 2021-09-072022-09-12 Journal: Vaccine [Category] MERS, SARS, 진단, [키워드] 95% CI 95% confidence interval absence acute respiratory illness age Analysis analyzed antibody concentration Antibody concentrations assays association chest pain clinical symptom Concentration cough COVID-19 cumulative determine diagnosis of SARS-CoV-2 diarrhea difficulty breathing Epidemic Estonia Estonian European country Factor fatality Fatality rate Fever First wave Focusing Hospitalization hotspot IgG incidence individual Infection Infection fatality rate majority Multiple linear regression neutralizing antibody participant PCR practitioners Prevalence random recruited regions required respiratory symptom SARS-CoV-2 SARS-CoV-2 IgG antibody selected sera seropositive subject Seroprevalence Shortness of breath stratified susceptible Symptom Symptoms Tallinn Total [DOI] 10.1016/j.vaccine.2021.07.093 PMC 바로가기 [Article Type] Article
Antibodies Responses to SARS-CoV-2 in a Large Cohort of Vaccinated Subjects and Seropositive PatientsArticle Published on 2021-07-012022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] age analyses antibody Antibody concentrations Antibody Response Antigen BNT162b2 collected Concentration COVID-19 COVID-19 vaccination COVID-19 vaccine IgG IgG antibody immunization Male sex multivariable natural infection Older age per day persistence regression analysis required response S1/S2 SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 positive patient SARS-CoV-2 vaccination serological significantly socio-demographic statistically statistically significant reduction subject Support the disease the SARS-CoV-2 vaccination Vaccine Vaccine development [DOI] 10.3390/vaccines9070714 PMC 바로가기 [Article Type] Article
Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios산모 및 신생아 제대혈 SARS-CoV-2 항체 및 태반 전달 비율 평가Article Published on 2021-06-012022-09-11 Journal: JAMA Pediatrics [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age analyzed antibody antibody concentration Antibody concentrations Antibody Response antibody transfer Asian assessment association Asymptomatic black Blood blood specimen Clinical data cohort study Combination Concentration CORD Cord blood coronavirus coronavirus disease Coronavirus disease 2019 correlated Demographic and clinical data during pregnancy enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Hispanic IgG IgG antibody IgM IgM antibodies IgM antibody Immunity Infant Infants Infection interquartile range management Maternal maternal antibody median Mild moderate mother Neonatal Newborn outcome parturient Philadelphia Placenta positively correlated Pregnancy Ratio receptor Receptor-binding domain respiratory SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 specific antibodies SARS-CoV-2 specific antibody SARS-CoV-2 spike protein sera seronegative seropositive severe acute respiratory syndrome Coronavirus severe coronavirus disease significantly lower specimen Spike protein study cohort subsequent symptomatic infection the receptor-binding domain the SARS-CoV-2 time of delivery took place transfer transferred understanding Vaccination strategies were measured white women [DOI] 10.1001/jamapediatrics.2021.0038 PMC 바로가기 [Article Type] Article