Observed Antibody Space: A diverse database of cleaned, annotated, and translated unpaired and paired antibody sequencesTools for Protein Science Published on 2021-10-292022-10-28 Journal: Protein Science : A Publication of the Protein Soc [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Amino acid annotated antibody sequences annotation antibody antibody database antibody repertoire antibody sequence available data B‐cell BCR‐seq coronavirus database disease driven by FASTQ files group increasingly individual nucleotide OAS Observed Observed Antibody Space (OAS) offer parameter problem provide receptor repertoire researcher sequence Sequencing sequencing data Space therapeutic translated vaccine responses Volume [DOI] 10.1002/pro.4205 PMC 바로가기 [Article Type] Tools for Protein Science
Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening단일 B 세포 스크리닝을 통한 고친 화성, 강력한 SARS-COV-2 중화 항체의 발견 및 특성Article Published on 2021-10-202022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, [키워드] ACE2 antibodies antibody Antibody generation antibody repertoire Applied immunology binding biologics coronavirus disease COVID-19 Critical Diagnosis Diseases high affinity highlight IgG1 immunized mice Infectious disease Infectious diseases Intervention Isolation memory B cells monoclonal antibodies Neutralizing activity Neutralizing antibodies neutralizing antibody Novel coronavirus novel coronavirus disease Prophylactic Rapid Receptor-binding domain SARS-CoV-2 SARS-CoV-2 neutralizing antibody single B cell Strategy the receptor-binding domain Treatment valency was used [DOI] 10.1038/s41598-021-99401-x PMC 바로가기 [Article Type] Article
Plasma cell immunoglobulin heavy chain repertoire dynamics before and after tetanus booster vaccinationarticle Published on 2021-08-312024-09-01 Journal: Curr Top Med Mycol [Category] 파상풍, [키워드] antibody maturation antibody repertoire Ig sequence analysis tetanus toxoid Vaccine [Article Type] article
Rapid generation of potent antibodies by autonomous hypermutation in yeast Research Published on 2021-06-242022-10-05 Journal: Nature chemical biology [Category] SARS, 변종, 진단, [키워드] antibody antibody fragment antibody repertoire Antigen antigens applied approach autonomous binding clone DNA replication generate immunization mutate nanobody predominant Rapid receptor S glycoprotein selective targets the SARS-CoV-2 yeast [DOI] 10.1038/s41589-021-00832-4 [Article Type] Research
Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses초기 환자 반응의 심층 마이닝에서 교차 반응성 SARS-CoV-2 중화 항체Immunology Published on 2021-06-152022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] affected antibodies antibody antibody repertoire Antibody Response approach B cell B.1.1.28 B.1.1.7 B.1.351 BCR binding binding epitope blocking antibody Brazil conserved convergence COVID-19 cross-reactivity deep described epitope Epitopes highlight hospitalized COVID-19 patient hospitalized COVID-19 patients independent monoclonal antibodies monoclonal antibody Mutation Neutralizing antibodies neutralizing antibody occur passive immunization Patient phage display RBD binding receptor reduced reported response reveal SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 variants sensitivity sequence sequences Sequencing South Africa study group the RBD unlikely Vaccine Viral viral variant Viral variants [DOI] 10.3389/fimmu.2021.678570 PMC 바로가기 [Article Type] Immunology
Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients생식계열 IGHV3-53 인코딩 RBD 표적 중화 항체는 일반적으로 COVID-19 환자의 항체 레퍼토리에 존재합니다Research Article Published on 2021-06-062022-09-12 Journal: Emerging Microbes & Infections [Category] SARS, 진단, [키워드] ACE2 binding site activities antibody antibody repertoire antibody repertoire sequencing computational analysis conserved COVID-19 COVID-19 patient COVID-19 patients experiments generate germline heavy chain IGHV3-53 IGKV1-9 Laboratory mAb mAbs molecular MOST neutralizing antibody precursor Prevalence RBD RBD binding Receptor-binding domain recognize SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibodies sequence Sequencing shared clonotype Somatic hypermutation spike receptor-binding domain VH3-53 virus-neutralizing [DOI] 10.1080/22221751.2021.1925594 PMC 바로가기 [Article Type] Research Article
Generation of recombinant hyperimmune globulins from diverse B-cell repertoiresArticle Published on 2021-03-272022-10-04 Journal: Nature biotechnology [Category] MERS, SARS, 진단, [키워드] antibodies antibody antibody repertoire Antibody therapeutics Antibody-dependent enhancement approach B-cell convalescent deficiency demonstrated disease Efficacy generate Generation human donors hyperimmune immune immunized mice Intravenous immunoglobulin limitation lung mammalian mice molecular Neutralizing activity pathogen Patient polyclonal respiratory SARS-CoV-2 specificity therapeutic targets Variation Zika virus [DOI] 10.1038/s41587-021-00894-8 PMC 바로가기 [Article Type] Article
Neutralizing Monoclonal Anti-SARS-CoV-2 Antibodies Isolated from Immunized Rabbits Define Novel Vulnerable Spike-Protein Epitope면역된 토끼에서 분리된 단일클론 항-SARS-CoV-2 항체 중화는 새로운 취약한 스파이크-단백질 에피토프를 정의합니다Article Published on 2021-03-262022-09-01 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] Anti-RBD antibodies antibody antibody repertoire Antigen approaches binding domain cell sorting characterization Combination Course COVID-19 COVID-19 therapy demonstrated Diagnosis diagnosis of SARS-CoV-2 disease distinct domain distinct domains domain Efficiency elicit epitope epitope mapping Epitopes Genetic variant immune response immunization immunized Immunotherapy IMPROVE in vitro Infection Isolated monoclonal antibodies monoclonal antibody mounted Neutralizing neutralizing antibody novel NTD Prevent profiles rabbit rabbit immunization RBD recombinant antigens repertoire representing SARS-CoV-2 SARS-COV-2 infection significantly Single Cell single cells single-cell sort specificity spike Spike protein the antibody the RBD therapy Viral viral spike protein [DOI] 10.3390/v13040566 PMC 바로가기 [Article Type] Article
Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection인간의 일반적인 유전적 변이가 SARS-CoV-2 감염에 대한 시험관 내 감수성에 영향을 미침Article Published on 2021-03-092022-09-11 Journal: Stem Cell Reports [Category] SARS, 변종, [키워드] addition alveolar antibody repertoire Brain Cell clinical complications clinical heterogeneity common Comorbidities contribute COVID-19 COVID-19 pandemic CRISPR disease drugs etiologic agent facilitate furin FURIN rs4702 genetic study Genetic variant Genetic variation healthy individual healthy individuals help Host host genetics host response Human human induced pluripotent stem cell identify Impact in vitro individual individuals Infection influence males Neuron neurons polymorphism predict principle protease SARS-CoV-2 single-nucleotide single-nucleotide polymorphism stem cell UTR Variability viral infection Viral load [DOI] 10.1016/j.stemcr.2021.02.010 PMC 바로가기 [Article Type] Article
Dromedary camels as a natural source of neutralizing nanobodies against SARS-CoV-2Research Article Published on 2021-03-082022-10-30 Journal: JCI Insight [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Analysis antibodies antibody antibody repertoire Antigen B cell coronavirus coronavirus disease COVID-19 cross-neutralizing cross-neutralizing antibody cross-reactive antibody cross-reactivity demonstrated Dromedary epitope epitope mapping Health humans hyperimmune immunoassay immunofluorescence immunogenic immunoprecipitation Immunotherapy investigated linear MERS-CoV Microarray Middle East nanobody Neutralizing peptides Potential treatment Prophylactic Proteins Pseudovirus neutralization assays respiratory syndrome coronavirus S trimer SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 proteins Sequencing seropositive specificity Support tested therapeutic agent Treatment [DOI] 10.1172/jci.insight.145785 PMC 바로가기 [Article Type] Research Article