Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies신종 코로나바이러스에 대해 일반적으로 처방되는 항우울제의 강력한 항바이러스 활성: 시험관 내 및 실리코 약물 용도 변경 연구Article Published on 2022-07-282022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] activities activity amitriptyline anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Anti-viral antidepressant antidepressants antiviral activity clinical trials coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Depression disorder disorders drug eating disorders effective Efficacy eight evaluated FDA-approved drug FDA-approved drugs FIVE imipramine in silico in vitro in vivo M pro MERS MERS-CoV migraine molecular docking studies Molecular docking study neuralgia pandemic Paroxetine Patient performed Prophylaxis protease reported symptom Result SARS-CoV-2 sertraline suggested symptomatic and asymptomatic symptoms of depression treating COVID-19 Treatment [DOI] 10.1038/s41598-022-17082-6 PMC 바로가기 [Article Type] Article
Antidepressants for COVID-19: A systematic reviewReview article Published on 2022-06-012022-10-05 Journal: Journal of affective disorders [Category] 임상, [키워드] antidepressant antidepressants Chinese Clinical deterioration Cochrane Library coronavirus disease COVID-19 COVID-19 patient COVID-19 patients determine dropout rate Efficacy and safety Evidence examined fluvoxamine hospitalisation journal Mortality objective patients with COVID-19 Placebo prospective cohort study PsycINFO randomized clinical trial RCT RCTs reduced reducing researcher Result retrospective Retrospective study risk supported systematic review Treatment was performed [DOI] 10.1016/j.jad.2022.03.059 [Article Type] Review article
Consumption of Psychiatric Drugs in Primary Care during the COVID-19 PandemicObservational Study Published on 2022-04-142022-10-04 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] Analysis antidepressants anxiolytics Care changes in Consumption COVID-19 COVID-19 pandemic cross-sectional database dose drug drug consumption drug prescription drugs groups Health highest hypnotic-sedatives increase in Older performed Primary Health Care Psychiatric psychiatric drugs. Public Research Spain statistically significant System The effect size was measured was performed while women [DOI] 10.3390/ijerph19084782 PMC 바로가기 [Article Type] Observational Study
A randomised controlled trial investigating the clinical and cost-effectiveness of Alpha-Stim AID cranial electrotherapy stimulation (CES) in patients seeking treatment for moderate severity depression in primary care (Alpha-Stim-D Trial)Randomized Controlled Trial Published on 2022-04-042022-10-04 Journal: Trials [Category] 임상, [키워드] Alpha Alpha-Stim AID antidepressants Anxiety anxiety disorders Brain carried CES Clinical efficacy Controlled trial COVID-19 pandemic cranial Cranial electrotherapy stimulation Depression depressive symptom Depressive symptoms determine double-blind effective Effectiveness Efficacy Evidence greater help less Major depression moderate NHS offered parallel-group participant Patient primary care Primary outcome professional provide psychological treatment randomised controlled randomised controlled trial reduction in Safe scale seeking severity shown Symptom Treatment Trial View [DOI] 10.1186/s13063-022-06192-1 PMC 바로가기 [Article Type] Randomized Controlled Trial
Impact of COVID-19 Pandemic on the Use of Antidepressant and Antianxiety Pharmaceuticals as Well as Sick Leave in PolandCovid-19 Pandemic이 항우울제 및 항발성 제약의 사용 및 폴란드의 병가의 영향Article Published on 2022-02-142022-08-31 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), MERS, SARS, 치료제, [키워드] absence analyzed antianxiety antidepressant antidepressants Anxiety caused Clinical practice Consumption COVID-19 COVID-19 pandemic Depression Diagnosis Impact impacted Interrupted Measures medication mental condition mental health pandemic Patient pharmaceutical Pharmaceuticals physician Poland Psychiatric psychiatric patients reaction Research Sery sick leave significantly strain Stress time Treatment well Workplace [DOI] 10.3390/ijerph19042135 PMC 바로가기 [Article Type] Article
The effects of COVID-19 on the dispensing rates of antidepressants and benzodiazepines in CanadaCOVID-19가 캐나다의 항우울제 및 벤조디아제핀 조제 비율에 미치는 영향Article Published on 2022-02-012022-09-11 Journal: Depression and anxiety [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis analyzed antidepressant antidepressants Anxiety Benzodiazepine Canada caused changes in Community conducted COVID-19 COVID-19 pandemic cross-sectional Depression depressive detectable determine deviation disorders Effect Emergency Intervention medication medications MONITOR National pandemic pharmacological treatment Pharmacy population study Prevalence reduction in Research returned shown significant changes in state of emergency Symptom Tablet treat [DOI] 10.1002/da.23228 PMC 바로가기 [Article Type] Article
Analysis of Clinical Parameters, Drug Consumption and Use of Health Resources in a Southern European Population with Alcohol Abuse Disorder during COVID-19 PandemicCOVID-19 Pandemic 동안 알코올 남용 장애가있는 남유럽 인구에서 임상 파라미터, 약물 소비 및 건강 자원 사용 분석Observational Study Published on 2022-01-262022-08-31 Journal: International Journal of Environmental Research an [Category] SARS, 임상, 치료제, [키워드] Abuse alarm alcohol Alcohol Abuse alcohol dependence alcohol use disorder antidepressants benzodiazepines body mass body mass index Care changes in cholesterol clinical clinical variable clinical variables clinically Consumption country COVID-19 COVID-19 pandemic creatinine decompensation Diagnosis Diastolic blood pressure disorder disorders Disruption dose drug electronic medical record electronic medical records EMR glomerular filtration Glutamate HDL Health health resource health resources Health Service Health services healthcare LDL lifestyle lockdown maintenance men moderate Oxaloacetate Patient per day pharmacological Population primary care Psychological pyruvate Regional Registered reorganization resource service Social service social services Southern European Spain Student’s t -test Systolic blood pressure Total cholesterol triglycerides variable vulnerable population was performed [DOI] 10.3390/ijerph19031358 PMC 바로가기 [Article Type] Observational Study
Antidepressant drug treatment protecting from COVID-19: one more piece in the repurposing puzzleEditorial Published on 2022-01-202022-10-28 Journal: BJPsych Open [Category] COVID-19, [키워드] antidepressant antidepressants Cohort coronavirus disease COVID-19 COVID-19 disease Deterioration drugs Efficacy Evidence First wave hospital incidence Infection infection risk medical records medication medications on COVID-19 New York observation period pandemic Patient positive prevention protective effect Psychiatric reduced repurposing Retrospective analysis risk significantly lower SSRI therapy Treatment were infected [DOI] 10.1192/bjo.2021.1075 PMC 바로가기 [Article Type] Editorial
Low-Dose Fluvoxamine Modulates Endocytic Trafficking of SARS-CoV-2 Spike Protein: A Potential Mechanism for Anti-COVID-19 Protection by AntidepressantsPharmacology Published on 2021-12-162022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 antidepressant antidepressants Cell complex Concentration COVID-19 diversion Drug repurposing endocytosis endosomal trafficking Endosomes fluvoxamine HEK293T cells highlighting host receptor investigated mechanism membrane Potential Prophylactic protection protective effect provide resulting SARS-CoV-2 severe COVID-19 spike Spike protein the SARS-CoV-2 therapeutic upregulated [DOI] 10.3389/fphar.2021.787261 PMC 바로가기 [Article Type] Pharmacology
The acid sphingomyelinase/ceramide system in COVID-19COVID-19의 산성 스핑고미엘리나제/세라마이드 시스템Review Published on 2021-10-042022-09-10 Journal: Molecular Psychiatry [Category] MERS, SARS, 신약개발, 임상, 치료제, [키워드] acid addition antibody antidepressants Antiviral approved blockade Cell cell entry ceramide cleave clinically Course COVID-19 Degradation Diseases downregulation drug Effect favorable effect Fluoxetine fluvoxamine form framework functional Genetic hydroxyzine Infection infection with SARS-CoV-2 inhibit inhibitor inhibitors lowering medication medications Molecular biology Neutral observational studies observational study Open-label plasma membrane platform Prospective Study provide Randomized repurposing restored SARS-CoV-2 sphingomyelin Support [DOI] 10.1038/s41380-021-01309-5 PMC 바로가기 [Article Type] Review