A Secreted Form of the Hepatitis E Virus ORF2 Protein: Design Strategy, Antigenicity and ImmunogenicityArticle Published on 2022-09-262023-06-12 Journal: Viruses [Category] E형 간염, Fulltext, [키워드] antigenicity B-cell decoy hepatitis E virus Immunogenicity. ORF2 [DOI] 10.3390/v14102122 PMC 바로가기
Functional profiling of Covid 19 vaccine candidate by flow virometryArticle Published on 2022-09-012022-10-05 Journal: Vaccine [Category] SARS, 변종, 진단, 치료기술, [키워드] Antigen antigenicity clinical trial complex Covid 19 vaccine detect discovery phase expressed expression levels Flow virometry MONITOR monoclonal antibodies process improvement Protein provided required S protein S protein stability SARS-CoV-2 spike SARS-CoV-2 spike protein selected sequence the S protein the vaccine utility vaccine candidate Vaccine development Vaccines vesicular stomatitis virus virus inactivation VSV VSV virus [DOI] 10.1016/j.vaccine.2022.08.006 [Article Type] Article
Immune Escape Adaptive Mutations in Hemagglutinin Are Responsible for the Antigenic Drift of Eurasian Avian-Like H1N1 Swine Influenza VirusesArticle Published on 2022-08-242023-06-14 Journal: Journal of Virology [Category] Fulltext, 신종인플루엔자, [키워드] antigenicity EA H1N1 escape mutant HA protein Swine influenza virus. [DOI] 10.1128/jvi.00971-22 PMC 바로가기
Considering epitopes conservity in targeting SARS-CoV-2 mutations in variants: a novel immunoinformatics approach to vaccine design변이체에서 SARS-CoV-2 돌연변이 표적화에서 에피토프 보존성 고려: 백신 설계에 대한 새로운 면역정보학 접근Article Published on 2022-08-182022-09-11 Journal: Scientific Reports [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Adaptive immunity antibody antigenicity approach Avian flu calculated collected conserved Coronavirus-2 database Developing Efficacy epitope Epitopes event flu ideal identify IEDB immune Immune Epitope Database Immunity immunodominant immunogenicity immunoinformatics mutated Mutation mutations neutralization pathogenicity platform predicted preference provide reduce Region SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 mutation selected Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Shannon entropy similarity solution technique Vaccine design Vaccines variant variants virulence virus viruses [DOI] 10.1038/s41598-022-18152-5 PMC 바로가기 [Article Type] Article
Cell surface SARS-CoV-2 nucleocapsid protein modulates innate and adaptive immunity세포 표면 SARS-CoV-2 뉴클레오캡시드 단백질은 선천성 및 후천성 면역을 조절합니다Article Published on 2022-08-052022-09-11 Journal: Science Advances [Category] SARS, 변종, 치료기술, 치료법, 치료제, [키워드] activate adaptive antibody antigenicity bind Cell cell surface cells chemokine chemokines chemotaxis Combination conserved CoVs cross-reactive cytosol detect electrostatic heparan sulfate heparin high affinity high-affinity binding human CoVs immune cells Immunity induce infected cells inhibited Innate immune cells Innate immunity leukocyte leukocytes live cells MERS-CoV modulate neighboring cell neighboring cells nucleocapsid protein Protein released SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2-infected cell SARS-CoV-2-infected cells sequestering Strains sulfate sulfated T cell T cell responses transfected cell Vaccine zoonotic [DOI] 10.1126/sciadv.abp9770 PMC 바로가기 [Article Type] Article
Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group Research Published on 2022-08-012022-10-05 Journal: Communications Chemistry [Category] 변종, [키워드] analysis antibodies antibody antigenicity bind binding circulation complex cross-reactivity glycol humanized hydrogen bond interaction hydrogen bond interactions hydrophobic hydroxyl groups IMPROVE induce mechanism Neutral offer polar Polymer recognize replacement residue resulting Serine specificity therapeutic effects therapeutic efficacy Therapeutic molecule Van [DOI] 10.1038/s42004-022-00709-0 [Article Type] Research
In silico SARS-CoV-2 vaccine development for Omicron strain using reverse vaccinology역백신학을 이용한 오미크론 균주에 대한 In silico SARS-CoV-2 백신 개발Article Published on 2022-08-012022-09-11 Journal: Genes & genomics [Category] COVID19(2023년), SARS, 변종, [키워드] 3D structure 3D Structures ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allergenicity angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antigenic antigenicity applied B cell epitope B cell epitopes B.1.1.529 binding collected coronavirus develop Efficacy effort enzyme epitope Epitopes estimation final vaccine construct Health Organization in silico MHC I MHC II molecular docking analysis Mutation non-allergenic non-toxic omicron pandemic Physicochemical properties physicochemical property predict predicted Prevent profile RaptorX reduce reverse vaccinology SARS-CoV-2 SARS-CoV-2 vaccine second secondary structure secondary structures selected severe acute respiratory syndrome Coronavirus solubility Spread stability Structure tested the vaccine Toxicity Vaccine vaccine candidate vaccine construct Vaccine design Vaccine design. Vaccines variant viral genome sequences virus VoC was performed were used WHO wild type World Health Organization [DOI] 10.1007/s13258-022-01255-8 PMC 바로가기 [Article Type] Article
SARS-CoV-2 variants – Evolution, spike protein, and vaccinesArticle Published on 2022-08-012022-11-16 Journal: Biomedical journal [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome antigenicity Characteristics clinical feature coronavirus country COVID-19 disease epidemiological Evolution of SARS-CoV-2 knowledge mediated immunity Mutation omicron reduce rising SARS-CoV-2 SARS-CoV-2 variant spike spike mutations Spike protein Transmissibility Vaccine Vaccines Variant of concern. variants variants of concern virus VoC [DOI] 10.1016/j.bj.2022.04.006 PMC 바로가기
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathwaySARS-CoV-2 Omicron은 세포 진입 경로가 변경된 면역 탈출 변종입니다.Article Published on 2022-08-012022-09-11 Journal: Nature Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] Amino acid antigenicity B.1.1.529 BNT162b2 booster vaccination Cell cell entry Cell fusion ChAdOx1 changes in cornerstone COVID-19 described determined by Effectiveness endosomal entry endosomal entry pathway Immune escape Impaired in vitro increasingly individual induce mapped mRNA mRNA-1273 Mutation neutralization omicron Omicron variant Omicron variants pathogenicity pathway phenotype public health Receptor-binding domain reduction in Region replicative restored S2 domain SARS-CoV-2 sera Spike protein Spread Syncytia the receptor-binding domain the spike protein These data TMPRSS2 transmissible variant underlie Vaccine variant VoC VOCs was determined [DOI] 10.1038/s41564-022-01143-7 PMC 바로가기 [Article Type] Article
Cross-reactivity of eight SARS-CoV-2 variants rationally predicts immunogenicity clustering in sarbecoviruses8개의 SARS-CoV-2 변이체의 교차 반응성은 사베코바이러스의 면역원성 클러스터링을 합리적으로 예측합니다Article Published on 2022-07-272022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Administered Algorithm Analysis antigenicity Antisera Beta booster clade Clustering dose eight elicit evaluate guinea pigs Immune escape immune evasion immunized immunogens in silico information neutralization activity neutralize Neutralizing antibodies neutralizing antibody omicron other variants PIGS predict predicted pseudotyped quantification reduced Reinfection reported sarbecovirus Sarbecoviruses SARS-CoV-2 variant SARS-CoV-2 variants sera Spike protein Structure Vaccines variant variants variants of interest VoC VOCs VOI VOIs were used [DOI] 10.1038/s41392-022-01123-7 PMC 바로가기 [Article Type] Article