antiretroviral drugs – Page 2 – Communicable Diseases Research

Safety assessment of drug combinations used in COVID-19 treatment: in silico toxicogenomic data-mining approach

Research article

Published on 2020-11-012022-10-05
Journal: Toxicology and applied pharmacology [Category] SARS, 치료법,

[키워드] affected Anti-COVID-19 Therapy antibiotic antiretroviral drugs apoA1 approach Autoimmune diseases Azithromycin BCL2L1 benefit candidate drug CCL2 Chloroquine chloroquine/hydroxychloroquine clinical condition Combination Comparative COVID-19 CTSB CXCL8 CYP3A4 Cytoscape software demonstrated Diseases disorders downregulated drug drug combination dyslipidaemia expected expression greater ICAM1 IL1B IL6 immune response improvement in silico in silico Approach infected patient Inflammation involved lipid metabolism Lopinavir Patient pharmacological problems Research risk Ritonavir Safety SARS-CoV-2 therapy TNF Toxicogenomics Treatment was used
[DOI] 10.1016/j.taap.2020.115237 [Article Type] Research article

Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease

HIV-1 프로테아제의 약물 내성 관련 돌연변이 중 양성 상위성의 우세

Research Article

Published on 2020-10-212022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] alleviate antiretroviral drug antiretroviral drugs Author capture clinic clinical observation clinical observations Clinical studies clinical study clinically Combination combinations compensatory mutations deep sequencing Deleterious deleterious effect deleterious effects drug drug resistance Effect epistasis Evolution fitness Genetic genetic interactions greatly reduce HIV HIV-1 Impact in vitro inhibitors Interaction interactions involved likelihood long term majority mechanism mutant Mutation mutations observation outcome overcome pandemic patients persistence positive Prophylaxis protease Protease inhibitor protease inhibitors reduce Replication resistance mutations reversal reversion selection experiments sequence Support T cells therapy Viral viral genome viral replication
[DOI] 10.1371/journal.pgen.1009009 PMC 바로가기 [Article Type] Research Article

TAILoR (TelmisArtan and InsuLin Resistance in Human Immunodeficiency Virus [HIV]): An Adaptive-design, Dose-ranging Phase IIb Randomized Trial of Telmisartan for the Reduction of Insulin Resistance in HIV-positive Individuals on Combination Antiretroviral Therapy

TAILoR(인간 면역결핍 바이러스[HIV]의 TelmisArtan 및 InsuLin 내성): 복합 항레트로바이러스 요법을 받는 HIV 양성 환자의 인슐린 내성 감소를 위한 Telmisartan의 적응형 설계, 용량 범위 IIb상 무작위 시험

Articles and Commentaries

Published on 2020-05-152022-09-06
Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease,

[키워드] adaptive Analysis antiretroviral drugs Antiretroviral therapy Antiretrovirals ARMS cardiovascular disease check clinical Combination conducted Controlled trial demonstrated Efficacy evaluated fat had no HIV HIV infection homeostasis Human Human immunodeficiency virus identify IIb immunodeficiency virus improvement Improvements index individual Infection insulin insulin resistance Insulin sensitivity interim analysis Intervention investigated ISRCTN liver longitudinal longitudinal analysis measure metabolic abnormalities Metabolic abnormality metabolic disease morbidity and mortality multicenter no difference no differences no significant effect once daily Open-label participant Patient phase plasma Primary outcome primary outcome measure Randomized receiving recruited reduce reduction in Registration resistance Result risk secondary outcome measures significant effect Stage stage II telmisartan Trial with HIV
[DOI] 10.1093/cid/ciz589 PMC 바로가기 [Article Type] Articles and Commentaries

Efficacy and safety of dihydroartemisinin–piperaquine for treatment of Plasmodium falciparum uncomplicated malaria in adult patients on antiretroviral therapy in Malawi and Mozambique: an open label non-randomized interventional trial

말라위와 모잠비크에서 항레트로바이러스 요법을 받는 성인 환자의 Plasmodium falciparum 비합병증 말라리아 치료를 위한 디하이드로아르테미시닌-피페라퀸의 효능과 안전성: 공개 라벨 비무작위 개입 시험

Research

Published on 2019-08-202024-08-11
Journal: Malaria Journal [Category] 말라리아,

[키워드] antiretroviral drugs Dihydroartemisinin–piperaquine Drug–drug interactions Human immunodeficiency virus malaria
[DOI] 10.1186/s12936-019-2909-5 PMC 바로가기 [Article Type] Research

Short Communication: Reduced Nevirapine Concentrations Among HIV-Positive Women Receiving Mefloquine for Intermittent Preventive Treatment for Malaria Control During Pregnancy

단신: 임신 중 말라리아 예방을 위한 간헐적 예방 치료로 메플로퀸을 복용하는 HIV 양성 여성에서 네비라핀 농도 감소

Article

Published on 2018-11-012024-08-11
Journal: AIDS research and human retroviruses [Category] 말라리아,

[키워드] antiretroviral drugs HIV/AIDS malaria mefloquine Mother-to-child transmission Pregnancy
[DOI] 10.1089/aid.2018.0042 PMC 바로가기

Can Antiretroviral Drugs Be Used to Treat Porcine Endogenous Retrovirus (PERV) Infection after Xenotransplantation?

Review

Published on 2017-08-082023-05-31
Journal: Viruses [Category] Fulltext, 조류인플루엔자,

[키워드] antiretroviral drugs integrase PERV porcine endogenous retroviruses reverse transcriptase
[DOI] 10.3390/v9080213 PMC 바로가기 [Article Type] Review

Highlights from the 2014 International Symposium on HIV & Emerging Infectious Diseases (ISHEID): from cART management to the end of the HIV pandemic

Research

Published on 2014-08-212023-08-28
Journal: AIDS Research and Therapy [Category] E형 간염,

[키워드] antiretroviral drugs HCV hepatitis E HIV HIV cure HIV reservoirs HIV vaccine
[DOI] 10.1186/1742-6405-11-28 PMC 바로가기 [Article Type] Research

Liver Enzymes Elevation and Immune Reconstitution Among Treatment-Naïve HIV-Infected Patients Instituting Antiretroviral Therapy

Article

Published on 2011-03-242023-06-03
Journal: The American journal of the medical sciences [Category] B형 간염,

[키워드] antiretroviral drugs hepatotoxicity HIV/AIDS immune reconstitution Liver enzymes elevation
[DOI] 10.1097/MAJ.0b013e31811ec780 PMC 바로가기 [Article Type] Article