The Central Role of Extracellular Vesicles in the Mechanisms of Thrombosis in COVID-19 Patients With Cancer and Therapeutic StrategiesCell and Developmental Biology Published on 2022-01-122022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] activate aggravate amplification amplify Antithrombotic antithrombotic therapy Apoptosis benefit Blood blood cell Blood coagulation blood flow Cancer Cell clinical manifestations Coagulation coagulation cascade contribute contributing to COVID-19 COVID-19 patient cytokine Cytokine storm Cytokines storm early stage Endothelial cell facilitate highlight Immune cell incidence maintain mechanism Microparticle microparticles microthrombi Mortality oxygen saturation pathophysiological mechanism pathway Patient Phosphatidylserine positive feedback loop proinflammatory cytokines promote resulting role SARS-CoV-2 susceptibility severe COVID-19 infections Strategy subsequent suggested the disease thrombosis thrombus formation treatment strategy tumor cell Venous thrombosis viral clearance virus [DOI] 10.3389/fcell.2021.792335 PMC 바로가기 [Article Type] Cell and Developmental Biology
Impact of pre-admission antithrombotic therapy on disease severity and mortality in patients hospitalized for COVID-19Observational Study Published on 2022-01-012022-10-05 Journal: Journal of Thrombosis and Thrombolysis [Category] 임상, [키워드] 95% CI Admission age Analysis Anticoagulant Anticoagulants anticoagulation anticoagulation therapy antiplatelet Antiplatelet drugs Antithrombotic antithrombotic therapy Clinical outcome control group coronavirus disease COVID-19 COVID-19 infection COVID-19 patient disease disease severity evaluate evaluated group hospital Hospital admission Hospitalization ICU admission ICU admission rate ICU admission rates Impact intensive care medications Mortality no significant difference overall mortality Patient patients hospitalized protective role receiving reduce SARS-CoV-2 the patient therapy three group thromboembolic complication Treatment [DOI] 10.1007/s11239-021-02507-2 PMC 바로가기 [Article Type] Observational Study
Low in-hospital mortality rate in patients with COVID-19 receiving thromboprophylaxis: data from the multicentre observational START-COVID Register혈전 예방을 받는 COVID-19 환자의 낮은 병원 내 사망률: 다기관 관찰 START-COVID Register의 데이터Observational Study Published on 2022-01-012022-09-12 Journal: Internal and Emergency Medicine [Category] MERS, 임상, 진단, [키워드] Admission affected Antithrombotic Atrial fibrillation bleeding Cancer cause characteristic Cohort Comorbidities conducted COVID-19 COVID-19 disease COVID-19 infection COVID-19 patient Deep vein Deep vein thrombosis dosage drug DVT enoxaparin fondaparinux heparin high mortality rate Hospital stay Hospitalized hospitalized patients hypertension in-hospital mortality rate interstitial pneumonia Italian low molecular weight low molecular weight heparin major bleeding majority Mortality mortality rate mortality rates multicentre multivariable multivariable analysis Neurological disease observational study outcome pathology Patient patients hospitalized patients older patients with COVID-19 Pulmonary embolism receive receiving reduction retrospective severe interstitial pneumonia significantly survival thromboembolic thromboembolic disease Thromboembolism Thromboprophylaxis thrombosis thrombotic thrombotic event Thrombotic events treated Treatment Venous Thromboembolism [DOI] 10.1007/s11739-021-02891-w PMC 바로가기 [Article Type] Observational Study
Development and Implementation of an Online Global Pharmacovigilance Certificate Program During the COVID-19 PandemicCOVID-19 전염병 동안 온라인 글로벌 약물감시 인증 프로그램의 개발 및 구현Article Published on 2022-01-012022-09-12 Journal: Clinical and applied thrombosis/hemostasis : offic [Category] 진단, [키워드] Anticoagulant Antithrombotic benefit Certificate Chicago clinical trial Course COVID-19 COVID-19 pandemic Critical development disease drug Evidence Formal IMPROVE infectious agent management medication outcome pandemic Patient pharmacovigilance populations professional Program provided Regulatory risk safety sciences. Stage therapy university Vaccine [DOI] 10.1177/10760296221115112 PMC 바로가기 [Article Type] Article
Prothrombotic Milieu, Thrombotic Events and Prophylactic Anticoagulation in Hospitalized COVID-19 Positive Patients: A Review입원한 COVID-19 양성 환자의 혈전성 환경, 혈전성 사건 및 예방적 항응고제: 검토Review Published on 2022-01-012022-09-11 Journal: Clinical and applied thrombosis/hemostasis : offic [Category] 바이오마커, [키워드] Activation anticoagulation anticoagulation therapy Antithrombotic antithrombotic therapy Coagulation Coagulation parameters coagulation pathways Cohort Consensus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease Critically ill critically ill patients cytokine cytokine release D-dimer D-dimer level described disease elevated Endothelial dysfunction Evidence Guidance incidence indicated initial intensity milieu morbidity and mortality pandemic pathophysiology Pathways patients patients with COVID-19 Post-mortem Preliminary data pro-inflammatory cytokine release Prophylactic prophylactic anticoagulation Randomized controlled trials respiratory Respiratory illness review risk SARS-CoV2 severe respiratory illness suggested therapeutic anticoagulation therapy thromboembolic thromboembolic complication thromboembolic complications Thromboembolic event Thromboembolic events Thromboembolism thrombosis [DOI] 10.1177/10760296221074353 PMC 바로가기 [Article Type] Review
Progress of thrombus formation and research on the structure-activity relationship for antithrombotic drugsReview article Published on 2022-01-012022-10-05 Journal: European journal of medicinal chemistry [Category] 비임상, [키워드] activity Anticoagulants Antithrombotic Antithrombotic drugs approved drug AstraZeneca bleeding blood clot candidate Cardio-cerebrovascular diseases category cause Compound COVID disease drug effective effort Factor Health high risk inhibitor mechanism Myocardial infarction onset of action Platelet Population Prevalence Progress promote receiving reported Research stroke therapeutic window thromboembolic disease thrombosis thrombotic disorder thrombotic disorders Thrombus thrombus formation unstable angina Vaccine [DOI] 10.1016/j.ejmech.2021.114035 [Article Type] Review article
COVID-19 and Venous Thromboembolism: From Pathological Mechanisms to Clinical ManagementReview Published on 2021-12-082022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] addition Anti-inflammatory drugs anticoagulant therapy antiplatelet Antithrombotic blood flow caused clinical Clinical prognosis clinical trial complex interaction controls Coronavirus disease 2019 COVID-19 COVID-19 patients critical COVID-19 patient disease severity Diseases drug drugs effective element Endothelial dysfunction Factor global pandemic Hospitalized hypercoagulability IMPROVE occur Occurrence outlined pathological pathological mechanism pathophysiological mechanism pathophysiology Prognosis risk factor SARS-COV-2 infection therapy thrombosis thrombotic thrombotic event Treatment treatments for COVID-19 Venous Thromboembolism Venous thrombosis VTE [DOI] 10.3390/jpm11121328 PMC 바로가기 [Article Type] Review
Bioactive Molecules Derived from Snake Venoms with Therapeutic Potential for the Treatment of Thrombo-Cardiovascular Disorders Associated with COVID-19COVID-19와 관련된 혈전-심혈관 질환 치료를 위한 치료 가능성을 지닌 뱀 독에서 추출한 생리활성 분자Review Published on 2021-12-012022-09-11 Journal: The protein journal [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome Algae Anti-inflammatory Anticoagulant antimicrobial antiplatelet Antiplatelet peptides Antithrombotic Antithrombotic compounds Antiviral antiviral proteins antiviral strategy Bioactivity Biotherapeutics Coagulopathy Compound compounds coronavirus coronavirus disease COVID-19 cytokine Cytokine storm effective Endothelial dysfunction expected genetic difference genetic differences IMPROVE induce Infection Inflammatory responses management mechanism molecule Nature offer pandemic peptide peptides plant platelet hyperactivation Potential Protein respiratory response SARS-CoV-2 SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Sickness snake Snake venom Snake Venoms Snake venoms. therapeutic Therapeutics thrombosis thrombotic disorder thrombotic disorders variant variants Venom Viral viral respiratory with COVID-19 [DOI] 10.1007/s10930-021-10019-4 PMC 바로가기 [Article Type] Review
State-of-the-art review – A review on snake venom-derived antithrombotics: Potential therapeutics for COVID-19-associated thrombosis?최신 리뷰 - 뱀 독 유래 항혈전제에 대한 리뷰: COVID-19 관련 혈전증의 잠재적 치료제?Review Published on 2021-12-012022-09-12 Journal: International journal of biological macromolecules [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome Anticoagulant antiplatelet Antithrombotic Blood coagulation Compound coronavirus coronavirus disease-2019 country COVID-19 deaths develop disease Diseases Effect Factor highlight increased mortality individual pandemic Pathways Potential respiratory illnesses responsible resulting SARS-CoV-2 severely ill patient snake Snake venom specificity therapeutic thrombosis thrombotic thrombotic complication treat treatment strategy while [DOI] 10.1016/j.ijbiomac.2021.10.015 PMC 바로가기 [Article Type] Review
Use of novel antithrombotic agents for COVID-19: Systematic summary of ongoing randomized controlled trialsCOVID-19에 대한 새로운 항혈전제의 사용: 진행중인 무작위 대조 시험의 체계적인 요약Article Published on 2021-12-012022-09-11 Journal: Journal of thrombosis and haemostasis : JTH [Category] SARS, 임상, 치료제, [키워드] acting Activation affecting Anti-inflammatory Antithrombotic Antiviral antiviral effects benefit clinical coagulation cascade Coagulopathy Conventional coronavirus disease Coronavirus disease 2019 COVID-19 defibrotide drug Effect endothelial Endothelial cell fibrosis Health Organization help identify IMPROVE include Inflammatory response macro management mechanism nafamostat Oxygenation Patient Patient management patients with COVID-19 pleiotropic potential mechanism Randomized controlled trial Randomized controlled trials RCT RCTs reduce registry Result searched systematic literature search Trial triggered utility Viral load World Health Organization [DOI] 10.1111/jth.15533 PMC 바로가기 [Article Type] Article