A case report of moderate COVID 19 patient managed through integrative approach (Siddha and conventional medicine)Case report Published on 2022-07-012022-10-05 Journal: Journal of Ayurveda and Integrative Medicine [Category] 바이오마커, 치료제, [키워드] adverse effect antiviral properties approach breathlessness Case report caused cough Course COVID COVID 19 CRP CT chest Day diagnosed effective Efficacy elevated Fever high mortality history Infection Integrative management laboratory investigation Loss of Smell male management moderate morbidity neutrophilia NLR Patient Pneumonia raised rapidly spreading disease severity Siddha tiredness treated Treatment [DOI] 10.1016/j.jaim.2022.100623 [Article Type] Case report
Proteomic Analysis of Human Milk Reveals Nutritional and Immune Benefits in the Colostrum from Mothers with COVID-19모유의 단백질체 분석은 COVID-19에 걸린 산모의 초유에서 영양 및 면역 이점을 나타냅니다Article Published on 2022-06-172022-09-11 Journal: Nutrients [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] adaptive Analysis Antiviral antiviral properties antiviral property benefit Breastfeeding breastmilk casein collected colostrum control group COVID-19 COVID-19 patient COVID-19 patients debate epitope Epitopes Evidence evidence of exhibited glycosylation Health Organization healthy donors Human immune immune-related protein immune-related proteins Immunoglobulin Infant Infection lack mass spectrometry mature milk milk molecular basis mother protective effect Protein proteomics recognizing recommendation risk SARS-CoV-2 significantly higher significantly lower Structure total protein unique upregulated viral entry virus virus transmission whey protein. while with COVID-19 World Health Organization [DOI] 10.3390/nu14122513 PMC 바로가기 [Article Type] Article
Potential Use of Tea Tree Oil as a Disinfectant Agent against Coronaviruses: A Combined Experimental and Simulation Study코로나바이러스에 대한 소독제로 티트리 오일의 잠재적 사용: 결합된 실험 및 시뮬레이션 연구Article Published on 2022-06-122022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] 1,8-cineole absence accelerated agent Antifungal antiviral activity antiviral properties Combined Complete components Compound Contamination coronavirus COVID-19 pandemic demonstrated disinfectant disinfectant agent Dynamics Effect effective essential oil fusion GaMD glycoprotein HCoV HCoV-OC43 Human coronavirus human coronavirus OC43 limit mechanism mechanism of action Melaleuca alternifolia membrane molecular dynamics molecular dynamics simulations Oil performed Potential Protein Safe SARS-CoV-2 SARS-CoV-2 envelope Simulation spike glycoprotein tea Tea tree oil tea tree oil. terpinen-4-ol the SARS-CoV-2 the Spike tree viral entry virion virucidal [DOI] 10.3390/molecules27123786 PMC 바로가기 [Article Type] Article
Lithium salts as a treatment for COVID-19: Pre-clinical outcomesCOVID-19 치료제로서의 리튬염: 전임상 결과Article Published on 2022-05-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 임상, 치료법, 치료제, [키워드] advance Anti-inflammatory anti-SARS-CoV-2 Antiviral antiviral properties antiviral property approach approved drug clinical trial clinical trials Concentration controls coronavirus disease Coronavirus disease 2019 COVID-19 disease dose-dependent manner Effect effective drug effective drugs Effects evaluate evaluated Evidence evidence of experiment glycogen glycogen synthase hamster hamsters identifying Inflammation inhibited less lithium lung Lungs microscopic observation Mortality N protein Nasopharyngeal swab nasopharyngeal swabs neutral red outcome patients Pre-clinical trial Replication replication of SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2. significantly higher supernatant supernatants Support therapeutic effect Toxicity treated Treatment viral control Viral load virus [DOI] 10.1016/j.biopha.2022.112872 PMC 바로가기 [Article Type] Article
Implication of in silico studies in the search for novel inhibitors against SARS-CoV-2SARS-CoV-2에 대한 새로운 억제제를 찾기 위한 in silico 연구의 의미Review Published on 2022-05-012022-09-11 Journal: Archiv der Pharmazie [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Ad26.COV2.S affected Antiviral antiviral drug antiviral phytoconstituents antiviral properties antiviral property approved AstraZeneca AZD1222 BBIBP-CorV Bharat BNT162b2 carried caused combating Corona CoronaVac coronavirus country COVID-19 COVID-19 infection database disease drug Drug administration effective effective vaccine Emergency use food Health Organization in silico in silico screening in vitro in vivo India individual inhibitor inhibitors inhibitors of SARS-CoV-2 janssen library Ligand Medicine Medicines Moderna molecular molecular docking molecular docking. mRNA mRNA-1273 Mutation occurred pandemic pandemic disease performed Pfizer/BioNTech plant plants PubChem Remdesivir researcher SARS-CoV-2 severe acute respiratory syndrome Coronavirus silico studies Sinopharm Sinovac Spread targets Treatment treatment of COVID-19 Vaccine Vaccines variants of SARS-CoV-2 Veklury WHO World Health Organization Wuhan Wuhan, China Zinc [DOI] 10.1002/ardp.202100360 PMC 바로가기 [Article Type] Review
Comparative Greenness Metric Estimates for Content Uniformity Testing of Anti-Cov-2, GS-5734 in Commercial Vials: Validated Micellar Electrokinetic Chromatographic Assay상업용 바이알에서 Anti-Cov-2, GS-5734의 함량 균일성 테스트에 대한 비교 녹색도 측정법 추정: 검증된 미셀 동전기 크로마토그래피 분석Article Published on 2022-04-272022-09-11 Journal: Journal of AOAC International [Category] 치료기술, 치료제, [키워드] Analysis Antiviral antiviral drug antiviral properties antiviral property applied approved borate borate buffer can be used clinical trials Community Comparative content coronavirus correlation coefficient COVID-19 drug Drug administration Ebola Ebola virus effective estimate food green GS-5734 harmonization International Conference linear metric pandemic pharmaceutical industry phosphoramidate positive Remdesivir selectivity sensitivity silica sodium sodium dodecyl sulfate solvent sulfate Testing treat Treatment U.S. Food and Drug Administration uniformity urge viruses was used widespread [DOI] 10.1093/jaoacint/qsac001 PMC 바로가기 [Article Type] Article
Discovery of a Natural Product with Potent Efficacy Against SARS-CoV-2 by Drug Screening약물 스크리닝을 통해 SARS-CoV-2에 강력한 효능을 지닌 천연물 발견Article Published on 2022-03-012022-09-11 Journal: Interdisciplinary sciences, computational life sci [Category] SARS, 신약개발, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against alveolar epithelial cells Analysis angiotensin angiotensin-converting enzyme-2 Antiviral antiviral peptides antiviral properties attachment AVP binding binding affinity binding free energies binding free energy caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cyanovirin-N demonstrated domain drug Drug screening enzyme epithelial cells half-maximal inhibitory concentration host cell host cells human Angiotensin-converting enzyme Infection inhibit inhibited Interaction Molecular simulation natural Novel coronavirus novel coronavirus disease peptide peptides potent Prevent product provided RBD RBD binding RBD complex Receptor-binding domain recruitment residue SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2. Screening severe acute respiratory syndrome Coronavirus spike glycoprotein Spread Structural analysis suppressed Therapeutic approach [DOI] 10.1007/s12539-021-00477-w PMC 바로가기 [Article Type] Article
[Translated article] Hydroxychloroquine: An Essential Drug in Dermatology and Its Controversial Use in COVID-19Research article Published on 2022-02-012022-10-05 Journal: Actas Dermo-Sifiliográficas [Category] 치료제, [키워드] adverse effects Anti-inflammatory antimalarial antiviral properties breastfeeding women can be used caused children clinical COVID-19 Dermatology Diseases drug erythematous Essential granuloma Hydroxychloroquine immune system immunomodulatory Lichen planus lupus erythematosus meta-analysis porphyria pregnant Prevent recent Regular safety profile sarcoidosis SARS-CoV-2 supply shortage Supply shortages suppress therapy treat [DOI] 10.1016/j.ad.2022.01.012 [Article Type] Research article
A short focus, azithromycin in the treatment of respiratory viral infection COVID-19: efficacy or inefficacy?짧은 초점, 호흡기 바이러스 감염 COVID-19 치료에서 아지스로마이신: 효능 또는 비효율?Review Published on 2022-02-012022-09-11 Journal: Immunologic research [Category] COVID19(2023년), SARS, 치료제, [키워드] acting addition antibiotic antiviral efficacy antiviral properties arrhythmia Arrhythmias assumed Azithromycin Clinical data Combination COVID-19 demonstrated determine Efficacy Evidence global pandemic immunomodulatory in vitro in vitro activity Infection Macrolide mechanism mechanism of action monotherapy Pneumonia pulmonary recent reported respiratory tract respiratory tract infection Respiratory tract infections respiratory viral infection responsible SARS-CoV-2 therapeutic efficacy Treatment variety viral respiratory Virology Virology. viruses [DOI] 10.1007/s12026-021-09244-x PMC 바로가기 [Article Type] Review
Azithromycin and hydroxychloroquine in hospitalised patients with confirmed COVID-19: a randomised double-blinded placebo-controlled trialRandomized Controlled Trial Published on 2022-01-062022-10-05 Journal: The European Respiratory Journal [Category] Fulltext, SARS, 임상, [키워드] acute respiratory syndrome airway antibiotic antiviral properties Azithromycin cause Combination control group coronavirus coronavirus disease COVID-19 criteria days alive death discharged double-blind double-blinded enrolment hospital hospitalisation hospitalised hospitalised patient Hydroxychloroquine immunomodulatory effects IMPROVE in vitro induce intensive care interim analysis interquartile range Intervention intervention group median monitoring board multicentre nine occurred outcome Patient patients patients receiving placebo patients with COVID-19 Placebo placebo-controlled trial positive Primary outcome randomisation randomised recruited reverse transcription PCR SARS-CoV-2 survival the placebo group Trial [DOI] 10.1183/13993003.00752-2021 PMC 바로가기 [Article Type] Randomized Controlled Trial