Ligand-based discovery of coronavirus main protease inhibitors using MACAW molecular embeddingsArticle Published on 2023-12-012022-11-15 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] 치료제, [키워드] antiviral properties binding affinity cells Cheminformatics Compound compounds conducted coronavirus dataset dose-dependent inhibition drug design Drug discovery evaluate half-maximal inhibitory concentration in silico inhibitor inhibitory effect ligand-based drug design M pro machine learning machine-learning molecular protease Protease inhibitor screened selected thought Toxicity Virtual screening virus infectivity [DOI] 10.1080/14756366.2022.2132486 PMC 바로가기
Derivation, Functionalization of (S)-Goniothalamin from Goniothalamus wightii and Their Derivative Targets SARS-CoV-2 MPro, SPro, and RdRp: A Pharmacological PerspectiveArticle Published on 2022-10-172022-11-15 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] (S)-Goniothalamin Anti-viral anticancer antioxidant antiviral properties antiviral property approach characterization complex Compound coronavirus COVID-19 derivation derivative disease drug examined LC-MS molecular molecular dynamics MPro NMR pandemic performed phytochemical platform Pro RdRP required Research SARS-CoV-2 SARS-COV-2 infection Simulation study spike glycoprotein target target protein threat [DOI] 10.3390/molecules27206962 PMC 바로가기
Hesperetin and the PI3K/AKT pathway: Could their interaction play a role in the entry and replication of the SARS-CoV-2?Article Published on 2022-09-012022-11-16 Journal: Journal of food biochemistry [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Anti-inflammatory antioxidant antiviral properties cell proliferation changes COVID-19 Effect Evidence hesperetin hesperetin. host cell host cells Inflammatory response Inflammatory responses Interaction involved molecular mechanism pathogenesis of SARS-CoV-2 pathway pharmacological PI3K/AKT Potential treatment protein synthesis Replication SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection signaling pathway subsequent therapeutic effect viral entry Viral particles [DOI] 10.1111/jfbc.14212 PMC 바로가기
Molecular mechanisms and therapeutic effects of different vitamins and minerals in COVID-19 patients코로나19 환자에서 다양한 비타민과 미네랄의 분자 기전과 치료 효과Review Published on 2022-09-012022-09-11 Journal: Journal of trace elements in medicine and biology [Category] 바이오마커, 변종, 유전자 메커니즘, 치료제, [키워드] activities addition Anti-inflammatory drugs antioxidant antioxidants Antiviral antiviral properties antiviral property boost component copper correlation COVID-19 COVID-19 patient COVID-19 patients Critical Critical illness cytokine release Cytokines disease Effect Factor Health high mortality immune function immune functions immune system Increased Infectious disease Inflammation Inflammatory cytokine Inflammatory cytokines iron lack manganese mechanism metabolic processe metabolic processes Micronutrient micronutrients mineral Minerals modulate mortality rate mortality rates oxidative stress Prevalence rapidly spreading disease reason remedy respiratory distress SARS-CoV-2 Selenium severe COVID-19 Severe respiratory distress Support therapeutic effect Trace element trace elements Treatment Vitamin vitamin A vitamins Zinc [DOI] 10.1016/j.jtemb.2022.127044 PMC 바로가기 [Article Type] Review
The effect of ivermectin on the viral load and culture viability in early treatment of nonhospitalized patients with mild COVID-19 – a double-blind, randomized placebo-controlled trialRandomized Controlled Trial Published on 2022-09-012022-10-04 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 신약개발, 임상, 치료법, 치료제, [키워드] 95% confidence interval Anti-SARS-CoV-2 Activity antiparasitic antiviral properties COVID-19 Culture cultures cycle threshold double-blind double-blinded early treatment Endpoint evaluated Infectivity Infectivity duration Ivermectin ivermectin group less Mild multivariable logistic regression Nasopharyngeal swab negative test Odds ratio Patient patients with COVID-19 per-protocol Placebo positive primary endpoint Primary outcome randomized placebo-controlled trial reached receiving recruitment reduce reduction reflected SARS-CoV-2 screened supported the placebo group Transmission Trial viability viral cultures Viral cultures. Viral load was obtained [DOI] 10.1016/j.ijid.2022.07.003 PMC 바로가기 [Article Type] Randomized Controlled Trial
Enoxaparin for primary thromboprophylaxis in symptomatic outpatients with COVID-19 (OVID): a randomised, open-label, parallel-group, multicentre, phase 3 trialClinical Trial Published on 2022-08-012022-10-05 Journal: The Lancet. Haematology [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] 1:1 95% CI acute COVID-19 adjusted relative risk age Anti-inflammatory effects Antithrombotic antiviral properties assigned assumption Berlin body temperature clinically Control control group COVID-19 criteria death Efficacy eight eligible enoxaparin event rates foundation futility Germany heparin hospitalisation independent initial intention-to-treat population interim analysis investigator-initiated IQR Johanna major bleeding major bleeding event median age multicentre nine not reduce Older older patient Open-label outcome Outpatient parallel-group participant phase 3 trial Prevent Primary outcome Probability prothrombotic randomisation randomised Randomly receive Registered reported respiratory infection respiratory symptom risk Safety Monitoring Board Serious Adverse Event Standard of care statistical Study design study population Switzerland symptomatic Thromboprophylaxis Treatment Trial university University of Zurich was done were recorded with COVID-19 women [DOI] 10.1016/S2352-3026(22)00175-2 PMC 바로가기 [Article Type] Clinical Trial
Immunomodulation of Mesenchymal Stem Cells in Acute Lung Injury: From Preclinical Animal Models to Treatment of Severe COVID-19급성 폐 손상에서 중간엽 줄기 세포의 면역 조절: 전임상 동물 모델에서 중증 COVID-19 치료까지Review Published on 2022-07-252022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal animal model antiviral properties antiviral property caused Cell Cell therapy clinical trial clinical trials coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytokine storm highlight immunomodulation immunomodulatory Infection lung Lung injury mass Mesenchymal stem cells Model Mortality MSC MSC therapy MSCs outcome pandemic Pathogenesis patients with COVID-19 potential mechanism potential mechanisms Preclinical public health Reinfection respiratory distress Respiratory distress syndrome risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus STEM stem cells syndrome the SARS-CoV-2 tissue repair treat vaccination vaccine breakthrough infection vaccine breakthrough infections Viral variants [DOI] 10.3390/ijms23158196 PMC 바로가기 [Article Type] Review
Network Pharmacology and Molecular Docking Elucidate the Underlying Pharmacological Mechanisms of the Herb Houttuynia cordata in Treating Pneumonia Caused by SARS-CoV-2네트워크 약리학 및 분자 도킹은 SARS-Cov-2로 인한 폐렴 치료에서 허브 호우 트 튜 니아 코타 타의 근본적인 약리학 적 메커니즘을 설명합니다.Article Published on 2022-07-212022-08-31 Journal: Viruses [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro ACE2 activity afzelin Analysis antiviral properties apigenin applied approach Asian caused China Combination docking DPP4 ELANE expression profiling Factor Herb herbal medicine High-throughput sequencing Houttuynia cordata HSP90AA1 IL6 ingredient integration involved Jak-STAT Japan kaempferol MAPK MAPK1 mechanism metabolite molecular molecular docking molecular dynamics Molecular dynamics simulation network network pharmacology NF-kB pharmacological pharmacological mechanism Pharmacology PI3K Pneumonia provide pulmonary infections quercetin reported required Research SARS-CoV-2 Sequencing SERPINE1 signaling pathways STAT suggested systemic level target therapeutic therapeutic effect therapeutic potential therapy treat treating [DOI] 10.3390/v14071588 PMC 바로가기 [Article Type] Article
A novel inactivated virus system (InViS) for a fast and inexpensive assessment of viral disintegration바이러스 분해에 대한 빠르고 저렴한 평가를 위한 새로운 불활성화 바이러스 시스템(InViS)Article Published on 2022-07-082022-09-11 Journal: Scientific Reports [Category] 치료제, [키워드] Antiviral antiviral agent Antiviral agents antiviral properties antiviral property caused complementary COVID-19 pandemic demonstrated determine disintegration dramatic increase facemask facilitate faster Fluorescence fluorescent fluorescent dye inactivated increase in organization pandemic porous reduce Research research and development sensitivity Standardization Support Surveillance System viral envelope viral particle Viral particles virus virus transmission [DOI] 10.1038/s41598-022-15471-5 PMC 바로가기 [Article Type] Article
More questions than answers for the use of inhaled nitric oxide in COVID-19Review article Published on 2022-07-012022-10-05 Journal: Nitric oxide : biology and chemistry [Category] 바이오마커, 임상, 치료제, [키워드] acute respiratory distress administration anti-inflammatory actions antiviral properties approved ARDS bloodstream clinical outcomes Cohort studies coronavirus disease COVID-19 Factor Hypoxemia IMPROVE improvements in oxygenation inactivation Inhaled lung mechanisms Neonates nitric oxide off-label Oxygenation pathological conditions patient selection patients with COVID-19 Potential treatment pulmonary hypertension question Randomized Randomized controlled trial Respiratory failure retrospective SARS-CoV-2 syndrome systemic effect therapy translated Treatment variety Vascular Ventilated [DOI] 10.1016/j.niox.2022.05.001 [Article Type] Review article