De novo design, retrosynthetic analysis and combinatorial synthesis of a hybrid antiviral (VTAR-01) to inhibit the interaction of SARS-CoV2 spike glycoprotein with human angiotensin-converting enzyme 2Research Article Published on 2020-10-152022-10-27 Journal: Biology open [Category] Coronavirus, COVID-19, Fulltext, [키워드] De novo designing ACE2 Analysis angiotensin converting enzyme 2 Antiviral antiviral molecule Ascorbate bind binding caused complex COVID-19 disease de novo dependent on docking domain enzyme hACE2 high mortality human Angiotensin-converting enzyme Hybrid antiviral molecule Hydroxychloroquine Infection inhibit interact Interaction MDs molecular Molecular dynamics simulation morbidity outbreak Pathogenesis Protein RBD RBD-ACE2 recognize responsible Retrosynthetic analysis ribavirin SARS-CoV2 SARS-CoV2 spike glycoprotein SARS-like coronavirus spike spike glycoprotein Spike protein tested the receptor-binding domain variant virus were used [DOI] 10.1242/bio.054056 PMC 바로가기 [Article Type] Research Article
A dissection of SARS-CoV2 with clinical implications (Review)Article Published on 2020-08-102023-06-14 Journal: International journal of molecular medicine [Category] MERS, SARS, [키워드] Antiviral treatment ARDS arginine Ascorbate coronavirus COVID-19 SARS-CoV2 Sepsis [DOI] 10.3892/ijmm.2020.4636 PMC 바로가기 [Article Type] Article
Impact of vitamins A, B, C, D, and E supplementation on improvement and mortality rate in ICU patients with coronavirus-19: a structured summary of a study protocol for a randomized controlled trialStudy Protocol Published on 2020-07-062022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 1:1 Abnormalities absence Ascorbate assigned baseline Biotin block BMI body temperature Chemotherapy clinical clinical trial clinical trials Complete condition control group COVID-19 CRP CT scan definitive diagnosis dissemination Duration element eligible patient ESR evaluate exclusion criteria expected female patient Folic acid Gender HIV Hospitalization Hypothesis ICU ICU patient IL6 Imam Impact IMPROVE include inclusion criteria intensive care unit Intervention invasive Iran kidneys liver lung male mortality rate New nicotinamide Non-invasive number objective organ outcome oxygen saturation pantothenate parallel group participant participated Patient patients patients with COVID-19 PCR per day percentage phosphate Placebo polymerase chain protocol pulmonary involvement randomization Randomized Randomized controlled trial Randomly receive registry renal researcher respiratory Riboflavin Sample size severity significantly sodium SpO2 Study protocol Supplementation Support table Tehran the patient thiamine nitrate TNF-α Treatment Two-arm viral disease Vitamin vitamin A Vitamin B Vitamin C Vitamin D Vitamin E WBC website weight with COVID-19 [DOI] 10.1186/s13063-020-04547-0 PMC 바로가기 [Article Type] Study Protocol
Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)Immunology Published on 2020-06-192022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Administered Antiviral antiviral action antiviral property Ascorbate ascorbic acid caused convalescent plasma coronavirus COVID-19 COVID-19 patient Critically ill death develop Efficacy Evidence flavonoids Health healthcare high-risk population immune system immunomodulatory property Immunonutrition imperative Intervention investigated overlapping pandemic pharmacological agent pharmacological treatment prevention Prophylaxis quercetin respiratory SARS-CoV-2 shown Stress synergistic the disease Treatment Vitamin Vitamin C [DOI] 10.3389/fimmu.2020.01451 PMC 바로가기 [Article Type] Immunology
Growth inhibitory effects of standard pro- and antioxidants on the human malaria parasite Plasmodium falciparumarticle Published on 2017-09-302024-09-01 Journal: Endocrine [Category] 말라리아, [키워드] albumin Ascorbate Diamide DTT erythrocyte H(2)O(2) IC(50) value malaria N-acetylcysteine Plasmodium redox [Article Type] article