Core genes involved in the regulation of acute lung injury and their association with COVID-19 and tumor progression: A bioinformatics and experimental study급성 폐 손상의 조절 및 COVID-19 및 종양 진행과의 연관성에 관여하는 핵심 유전자 : 생물 정보학 및 실험 연구Research Article Published on 2021-11-222022-09-10 Journal: PLoS ONE [Category] MERS, 유전자 메커니즘, 진단, [키워드] acute lung injury administration analysed anti-inflammatory agents Anti-inflammatory therapy association Atla bioinformatics Bioinformatics analysis cancers caused CCL2 changes in core correlation COVID-19 patient COVID-19 patients datasets DEGs Dexamethasone differentially expressed gene Differentially expressed genes down-regulation element expression functional annotation gene expression pattern gene expression patterns identify Ifi44 infectious involved LPS lung lung damage Lung inflammation lung inflammatory response Lung injury lung tissue marker mechanism mice Mmp8 molecular molecular markers molecular mechanism molecular mechanisms murine murine model neoplasia NODAL non-infectious overlap pathology Patient Plaur progression protein-protein interaction Ptx3 reconstruction Regulation regulatory network respiratory reversed RSAD2 Rtp4 Saa1 SARS-CoV-2 SARS-COV-2 infection SERPINE1 SOCS3 survival susceptible systemic inflammation text mining therapeutic target therapeutic targets Timp1 up-regulated were assessed whole-genome microarray with COVID-19 [DOI] 10.1371/journal.pone.0260450 PMC 바로가기 [Article Type] Research Article
Anatomical structures, cell types and biomarkers of the Human Reference Atlas Reviews Published on 2021-11-082022-10-05 Journal: Nature cell biology [Category] 바이오마커, [키워드] anatomical Anatomy Atla Biomarker Biomedical research Cell cell type cell types Clinical practice consortia example HRA Human International reference structures utility [DOI] 10.1038/s41556-021-00788-6 [Article Type] Reviews
Expression profile of SARS‐CoV‐2 cellular entry proteins in normal oral mucosa and oral squamous cell carcinoma정상 구강 점막 및 구강 편평 세포 암종에서 SARS-CoV-2 세포 진입 단백질의 발현 프로파일Short Communication Published on 2021-11-022022-09-11 Journal: Clinical and Experimental Dental Research [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] ACE2 angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Atla body tissues Cell cellular entry COVID‐19 dataset datasets enzyme Evidence examined except for expression expression level expression levels expression profile expression profiles expression profiling furin head cancer HPA Human independent lesion Microarray moderate mRNA neck cancer objective oral cancer oral mucosa organ organs profile protease Proteases Protein protein expression Proteins proteomics Public relative susceptibility Result risk Risk assessment SARS‐CoV‐2 SARS‐CoV‐2 infection Squamous cell Squamous cell carcinoma tissue tissues TMPRSS2 tongue transcriptomic were used [DOI] 10.1002/cre2.510 PMC 바로가기 [Article Type] Short Communication
A call for discovery: Re‐envisioning The Cancer Genome Atlas as a blueprint for a TCGA2.0—The COVID‐19 Genome AtlasEditorial Published on 2021-10-182022-11-01 Journal: Clinical and Translational Discovery [Category] COVID-19, [키워드] approach Atla atlas benefit Cancer Clinicians complications consequence COVID‐19 creating determinant disease effective Health impacted outcome pandemic Patient provide researchers Scientific community treat [DOI] 10.1002/ctd2.7 PMC 바로가기 [Article Type] Editorial
CytokineLink: A Cytokine Communication Map to Analyse Immune Responses—Case Studies in Inflammatory Bowel Disease and COVID-19CytokineLink: 면역 반응 분석을 위한 사이토카인 커뮤니케이션 맵 - 염증성 장 질환 및 COVID-19 사례 연구Article Published on 2021-08-292022-09-12 Journal: Cells [Category] MERS, 진단, [키워드] Affect applied assigned Atla Blood blood cell Cell cell type communication Consensus contribute COVID-19 Critical cytokine Cytoscape database defined demonstrated disease downstream effort expression data highlighting homeostatic conditions Human identify immune responses immunology Infectious disease inflamed colonic tissues Inflammatory Inflammatory bowel disease Inflammatory diseases information Interaction interactions intercellular Intercellular communication Map molecular weight NDEx network peptides Perturbation platform prevalent Protein receptor Repository resource reveal SARS-COV-2 infection Scientific community secretion subgroup of patients target cells Therapeutic strategies tissue ulcerative colitis [DOI] 10.3390/cells10092242 PMC 바로가기 [Article Type] Article
Pan-Cancer Analysis of Genomic and Prognostic Characteristics Associated With Coronavirus Disease 2019 RegulatorsMedicine Published on 2021-08-112022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE1 ACE2 AGT Analysis analyzed Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach Atla Biomarkers Cancer cancers Clinical characteristics coronavirus disease correlated COVID-19 COVID-19 regulators database drug drugs targeting evaluated expression level genetic alteration genetic alterations genomic alteration information Interaction mechanism Methylation outcomes Pan-cancer Pathways Patient portal potential mechanism Prognosis prognostic receptor regulator response RNA-seq data sensitivity serine protease significantly single nucleotide SLC6A19 solid tumor solid tumors Therapeutics TMPRSS2 tumorigenesis Variation widespread [DOI] 10.3389/fmed.2021.662460 PMC 바로가기 [Article Type] Medicine
Prognostic and immunological value of ATP6AP1 in breast cancer: implications for SARS-CoV-2유방암에서 ATP6AP1의 예후 및 면역 학적 가치 : SARS-COV-2에 대한 시사점Research Paper Published on 2021-07-152022-08-31 Journal: Aging (Albany NY) [Category] 바이오마커, 변종, [키워드] Accessory Alter association Atla ATP6AP1 ATPase bioinformatics Breast cancer Carcinogenesis cell type cell types co-expression correlated COVID-19 database disease stage enrichment estimation evaluate expression Factors Gene Expression Omnibus Human Immune cell immune cells immune infiltration immunological implication indicated infiltration investigated Kaplan-Meier methylated Methylation Multiple Mutation outcomes Patient Profiling Prognosis prognostic effect Prognostic value promote promoter reduced SARS-CoV-2 SARS-CoV-2 infections Subtypes susceptible System tissue tissues Transporting Tumor upregulated were used [DOI] 10.18632/aging.203229 PMC 바로가기 [Article Type] Research Paper
A Single-Cell Atlas of Lymphocyte Adaptive Immune Repertoires and Transcriptomes Reveals Age-Related Differences in Convalescent COVID-19 Patients림프구 적응 면역 레퍼토리 및 전사체의 단일 세포 아틀라스는 회복기 COVID-19 환자의 연령 관련 차이를 보여줍니다Comparative Study Published on 2021-07-122022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] Activation adaptive Adaptive immune response Adaptive immunity age Analysis antibody Atla B cell B cell receptor B cell receptors B cells B lymphocytes BCR CD4 CD8 Cell cell receptor clearance clone convalescent COVID-19 patient convalescent COVID-19 patients COVID-19 COVID-19 disease COVID-19 patient Critical cytotoxicity dependent on difference effector elderly patients elevated GNLY groups GzmA GZMH IgA immune Immunity implicated knowledge lymphocyte Lymphocytes marker outcome Patient patients plasma Plasma cell PRF1 receptor repertoire SARS-CoV-2 Sequencing single-cell T and B cells T and B lymphocytes T cell TCRs Transcriptome transcriptomes transition VDJ repertoire [DOI] 10.3389/fimmu.2021.701085 PMC 바로가기 [Article Type] Comparative Study
SARS-CoV-2 Host Receptor ACE2 Protein Expression Atlas in Human Gastrointestinal TractCell and Developmental Biology Published on 2021-06-112022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE2 ACE2 protein acute respiratory syndrome analyzed antibody Atla Cancer cancer cell cancers CCK-8 cells Colon Colon cancer coronavirus correlation counting death digestive distribution enzyme expressed expression expression level expression pattern Gastrointestinal gastrointestinal cancers gastrointestinal tract heterogeneous host cell Human IHC immunohistochemistry in vitro independent infect infected with SARS-CoV-2 Interaction liver Liver cancer not affect not correlated pancreas pancreatic Pancreatic cancer paraffin-embedded Patient Prognosis prognosis of patient Prognostic marker proliferation proportion protein expression receptor Result SARS-CoV-2 significantly significantly increased staining survival Symptoms tissue tissues tract tumor cell line was tested [DOI] 10.3389/fcell.2021.659809 PMC 바로가기 [Article Type] Cell and Developmental Biology
Downregulation of ACE2 expression by SARS-CoV-2 worsens the prognosis of KIRC and KIRP patients via metabolism and immunoregulationResearch Paper Published on 2021-05-102022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, SARS, [키워드] Accuracy ACE2 ACE2 expression acute respiratory syndrome animal model Atla bioinformatics Cancer Cancer patients Cancer therapy Cell clinical information clinical risk coronavirus correlated correlation database diagnosing downregulated downregulation enzyme exhibit expression function Gene Expression Gene Expression Omnibus GEO high risk host cell human tissues immune immune infiltration immunoregulation involved kidney metabolic pathway metabolism not correlated overall survival overlap Patient patient survival patients Predictive Prognosis renal Renal cancer SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell searched significantly survival Symptoms target tissue TMPRSS2 transmembrane serine protease upregulated Xena [DOI] 10.7150/ijbs.57802 PMC 바로가기 [Article Type] Research Paper