atorvastatin – Page 2 – Communicable Diseases Research

The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction

징크 핑거 전사 인자인 KLF2는 COVID-19 관련 내피 기능 장애로부터 보호합니다

Article

Published on 2021-07-122022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료법,

Statins and clinical outcomes in hospitalized COVID-19 patients with and without Diabetes Mellitus: a retrospective cohort study with propensity score matching

Observational Study

Published on 2021-07-102022-10-04
Journal: Cardiovascular Diabetology [Category] 임상,

[키워드] 1:1 95% CI administration appear association atorvastatin Clinical outcome Cohort conducted confounder COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients determine Diabetes Mellitus disease group Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient Inpatient intensive care mechanical ventilation medication Mortality multivariable multivariable analysis outcome Patient patients pleiotropic effect Primary outcome propensity score matching pursuit race randomized clinical trial reduce reduced reduction in mortality regression analysis Research design Result retrospective cohort study Safe severe disease severity of COVID-19 statin statins subgroup analysis supplementary material Support
[DOI] 10.1186/s12933-021-01336-0 PMC 바로가기 [Article Type] Observational Study

Studying the Effect of Taking Statins before Infection in the Severity Reduction of COVID-19 with Machine Learning

Research Article

Published on 2021-06-192022-10-27
Journal: BioMed Research International [Category] COVID-19, MERS,

Screening of drug databank against WT and mutant main protease of SARS-CoV-2: Towards finding potential compound for repurposing against COVID-19

Research article

Published on 2021-05-012022-10-05
Journal: Saudi Journal of Biological Sciences [Category] 변종, 신약개발, 치료제,

SARS-CoV-2 early infection signature identified potential key infection mechanisms and drug targets

SARS-CoV-2 조기 감염 시그니처는 잠재적인 주요 감염 메커니즘 및 약물 표적 식별

Research Article

Published on 2021-02-182022-09-10
Journal: BMC Genomics [Category] MERS, 신약개발, 유전자 메커니즘,

[키워드] addition antidepressants association atorvastatin BALF BALF cells bimodal biopsies Bronchoalveolar lavage fluid Bronchoalveolar lavage fluid cells candidate Candidates caused Cell characterized COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 outbreak COVID-19 treatments cultured cell cultured cells database dataset deaths Differential gene expression disease drug drug target early infection effective Efficacy expression profile Gene Expression gene signature HDAC healthy healthy and infected patients highlighting ibuprofen identify IFIT2 Immune cell immune cells infected patient infected with SARS-CoV-2 Infection infection mechanism inhibitors investigated ketoconazole lung lung biopsies mechanism moderate mononuclear cell mononuclear cells Mortality NFKBIA PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells PPP1R15A Previous studies previous study public health Result robust safety profile SARS-CoV-2 SARS-CoV-2 gene expression signature SARS-COV-2 infection Sequencing severely infected patient severely infected patients severity shown signature single-cell supplementary material the disease the SARS-CoV-2 therapy TNFAIP3 transcriptional activity treating SARS-CoV-2 infection Treatment Vaccine
[DOI] 10.1186/s12864-021-07433-4 PMC 바로가기 [Article Type] Research Article

Intermediate versus standard-dose prophylactic anticoagulation and statin therapy versus placebo in critically-ill patients with COVID-19: Rationale and design of the INSPIRATION/INSPIRATION-S studies

COVID-19 중증 환자에서 중간 용량 대 표준 용량 예방적 항응고제 및 스타틴 요법 대 위약: INSPIRATION/INSPIRATION-S 연구의 이론적 근거 및 설계

Article

Published on 2020-12-012022-09-11
Journal: Thrombosis research [Category] 임상,

[키워드] all-cause mortality Analysis anticoagulation antithrombotic therapy Arterial thrombosis atorvastatin bleeding Chain Reaction cohorts Composite Controlled trial coronavirus disease Coronavirus disease 2019 COVID-19 death double-blind eligibility criteria Enrollment Exploratory analyses Exploratory analysis extracorporeal membrane oxygenation factorial design hallmark hallmarks help hypothese Hypothesis immune response include independent inferiority inspiration intensity intention-to-treat intermediate limit liver enzyme liver enzymes major bleeding management manifestation matching placebo modified intention-to-treat Myopathy non-inferiority non-inferiority margin normal limit Odds ratio open open label Patient patients with COVID-19 per-protocol performed Placebo Platelet Platelet count polymerase chain polymerase chain reaction Prevent primary endpoint Prophylactic prophylactic anticoagulation question randomization Randomized Randomized controlled trial rationale Result reverse transcription reverse transcription polymerase chain reaction safety endpoint screened secondary endpoint Standard dose Standard-dose statin Stratified randomization subgroup tested therapy thrombocytopenia thrombosis thrombotic event Thrombotic events undergo Venous Thromboembolism Ventilator-free days VTE
[DOI] 10.1016/j.thromres.2020.09.027 PMC 바로가기 [Article Type] Article

Atorvastatin and Aspirin as Adjuvant Therapy in Patients with SARS-CoV-2 Infection: A structured summary of a study protocol for a randomised controlled trial

Letter

Published on 2020-10-302022-10-29
Journal: Trials [Category] Coronavirus, MERS, SARS,

[키워드] adjuvant Administered Adverse age alanine aminotransferase All study participant allergy approved ARDS Aspartate transaminase Aspirin atorvastatin benefit bleeding block randomization Breastfeeding C-reactive protein characterized clinical Clinical deterioration Clinical improvement Clinical outcome Coagulopathy collected data computer-generated conducted confirmed case control group COVID-19 COVID-19 patient COVID-19 patients CPK creatine phosphokinase Critical derivative discharge dissemination dose drug drug interaction ECMO Effect element Endotracheal intubation enrolment ethical committee evaluated examined excluded exclusion criteria Final Hepatitis HIV Hospital admission hospital discharge hospitalisation ICMR ICU admission in-hospital mortality include Inclusion India infected with SARS-CoV-2 Inflammatory marker interim analysis liver management mechanical ventilation Medical Science medication Mortality myalgia National Cancer Institute New Non-invasive number objective Open-label Other outbreak outcome outcomes pandemic parallel-group participant Patient patients Platelet Pregnancy Primary outcome progression Protease inhibitor protease inhibitors protocol randomised Randomised control trial randomised controlled trial randomize Randomized receiving recruited recruitment reference Registered registry renal replacement therapy respiratory RT-PCR Sample size SARS-CoV-2 SARS-COV-2 infection secondary outcome serum Shock statin status study period Study protocol supplementary material symptom onset Tablet therapy Treatment protocol Trial troponin usual care website WHO written consent written Informed Consent
[DOI] 10.1186/s13063-020-04840-y PMC 바로가기 [Article Type] Letter

A new advanced in silico drug discovery method for novel coronavirus (SARS-CoV-2) with tensor decomposition-based unsupervised feature extraction

텐서 분해 기반 비지도 특징 추출을 통한 신종 코로나바이러스(SARS-CoV-2)에 대한 새로운 첨단 in silico 약물 발견 방법

Research Article

Published on 2020-09-112022-08-13
Journal: PLoS ONE [Category] SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected alvocidib antiviral drug applied atorvastatin candidate canertinib cell line chloride clinical trial clinical trials Community Compound coronavirus costly COVID-19 Critical develop dibromochloromethane doxycycline drug drug candidate Drug discovery effective effective drug effective drugs experimental validation expression fluticasone gadolinium geldanamycin gene expression profile Gene expression profiles gentamicin identify in silico Ivermectin lung cancer meloxicam mitoxantrone motexafin gadolinium Novel coronavirus Numerous pandemic patients with COVID-19 quercetin radicicol respiratory SARS-CoV-2 Screen screened selected severe acute respiratory syndrome Coronavirus significantly sorafenib Tensor time-consuming treating COVID-19 trovafloxacin
[DOI] 10.1371/journal.pone.0238907 PMC 바로가기 [Article Type] Research Article

Statins as early therapy to mitigate COVID-19 (SARS-CoV-2)-associated ARDS and cytokine storm syndrome – time is of the essence

Medical Hypothesis

Published on 2020-04-182022-10-29
Journal: Journal of Clinical and Translational Research [Category] COVID-19,

[키워드] ACE 2 acute respiratory distress syndrome ARDS atorvastatin COVID-19 Cytokine storm Cytokine storm syndrome hyperinflammation microparticles mitigate SARS-CoV-2 statin statins therapy
PMC 바로가기 [Article Type] Medical Hypothesis

Impact of methylene blue and atorvastatin combination therapy on the apparition of cerebral malaria in a murine model

메틸렌 블루와 아토르바스타틴 병용 요법이 쥐 모델에서 뇌 말라리아 발생에 미치는 영향

Research

Published on 2013-04-152024-08-13
Journal: Malaria Journal [Category] 말라리아,

[키워드] anti-malarial drug atorvastatin in vivo malaria Methylene blue Plasmodium resistance
[DOI] 10.1186/1475-2875-12-127 PMC 바로가기 [Article Type] Research