A Dual Pharmacological Strategy against COVID-19: The Therapeutic Potential of Metformin and AtorvastatinReview Published on 2024-02-132024-09-05 Journal: Microorganisms [Category] update2024, [키워드] antiviral drugs atorvastatin COVID-19 metformin pharmacological repositioning [DOI] 10.3390/microorganisms12020383 PMC 바로가기 [Article Type] Review
Machine-learning-based analysis of the sensitivity and specificity on lipid-lowering effect of one-month-administered statins4200 Published on 2023-03-032024-09-05 Journal: Medicine [Category] update2024, [키워드] Algorithms atorvastatin Lipid machine-learning Screening [DOI] 10.1097/MD.0000000000033139 PMC 바로가기 [Article Type] 4200
Atorvastatin for reduction of 28-day mortality in hospitalized COVID-19 patients: study protocol for a randomized, double-blinded, placebo-controlled, clinical trial입원한 COVID-19 환자의 28일 사망률 감소를 위한 아토르바스타틴: 무작위, 이중 맹검, 위약 대조, 임상 시험을 위한 연구 프로토콜Article Published on 2022-08-082022-09-11 Journal: Trials [Category] SARS, 임상, [키워드] 28-day mortality 95% confidence interval Acute kidney injury added adjusted odds ratio All participants all-cause mortality anti-inflammatory drug approval assigned atorvastatin being clinical Clinical improvement clinical trial clinician Consequences Consistency coronavirus COVID-19 COVID-19 patient Delta disease double-blinded drug events healthcare worker Hmg coa hospital hospitalized COVID-19 hospitalized patients In-hospital in-hospital mortality Informed consent institutional review board intensive care isolation hospital logistic regression model mass vaccination mechanical ventilation Mortality neurological once daily P-value pandemic pandemic era participant Patient performed Placebo placebo-controlled Primary outcome protocol Psychological Randomized randomized clinical trial Randomized controlled trial receive recruited reduce mortality reduced reduction Registered registry Research SARS-CoV-2 Sepsis severity severity of COVID-19 standard treatment statins Study protocol supported Tablet the patient university vaccination [DOI] 10.1186/s13063-022-06619-9 PMC 바로가기 [Article Type] Article
Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials심혈관계 약물 및 코로나19 임상 결과: 무작위 대조 시험의 체계적인 검토 및 메타 분석Review Published on 2022-08-012022-09-11 Journal: British Journal of Clinical Pharmacology [Category] 임상, 진단, [키워드] 95% CI 95% confidence interval Accuracy ACEi ACEIs amlodipine angiotensin angiotensin receptor blocker angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors Anticoagulants anticoagulation antiplatelet approved ARBs Aspirin atorvastatin baseline blocker calcium calcium channel calcium channel blockers cardiovascular cardiovascular drugs Clinical outcome Completeness COVID-19 COVID-19 severity database drug Evidence had no Hospitalization identify initiated investigated Living systematic review mean difference meta-analyses Meta-analysis moderate Mortality no effect not affect observational studies observational study Other outcomes Prevent Quantitative Randomized controlled trial RCT RCTs receptor receptor blocker reported risk risk ratio searched severity sulodexide systematic review therapeutic therapeutic anticoagulation treat Trial trials [DOI] 10.1111/bcp.15331 PMC 바로가기 [Article Type] Review
Survival of the hospitalized patients with COVID-19 receiving atorvastatin: A randomized clinical trialRandomized Controlled Trial Published on 2022-07-012022-10-04 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 임상, [키워드] 95% confidence interval atorvastatin COVID-19 decrease duration of hospitalization Effect evaluate the effect FIVE Frequency greater hazard ratio Hospitalization hospitalized patient Hydroxychloroquine ICU intervention group intubation Kaletra® median Mortality mortality rate occurred outcome Patient patients died Pneumonia Probability progression Pulse rate randomized clinical trial Randomized controlled trial randomly divided receiving Sepsis Seven Standard therapy survival Symptom Treatment was performed with COVID-19 [DOI] 10.1002/jmv.27710 PMC 바로가기 [Article Type] Randomized Controlled Trial
Is there any association between plasma lipid profile and severity of COVID-19?혈장 지질 프로필과 COVID-19의 중증도 사이에 연관성이 있습니까?Article Published on 2022-06-012022-09-11 Journal: Clinical nutrition ESPEN [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] analyzed association atorvastatin Care caused characterized cholesterol concerning coronavirus correlated COVID-19 COVID-19 patient COVID-19 patients disease Disease progression disease severity event HDL-C HDL-cholesterol ICU Infectious disease Intensive LDL-C LDL-cholesterol less Lipoproteins majority multivariate multivariate Cox regression analysis non-survivor Non-survivors pandemic parameter Patient plasma plasma lipoprotein plasma lipoproteins Prognosis question regression analysis respiratory symptoms SARS-CoV-2 severity severity of COVID-19 single-center study statins survivor the patient Total cholesterol variant with COVID-19 [DOI] 10.1016/j.clnesp.2022.04.026 PMC 바로가기 [Article Type] Article
Drug repurposing for COVID-19 using graph neural network and harmonizing multiple evidence그래프 신경망을 사용하여 COVID-19에 대한 약물 용도 및 여러 증거 조화Article Published on 2021-11-302022-08-31 Journal: Scientific Reports [Category] 신약개발, 임상, 치료법, 치료제, [키워드] 2019 novel coronavirus 2019 novel coronavirus disease acetaminophen albuterol approach Aspirin atorvastatin Azithromycin candidate drug candidate drugs clinical trial collected conducted coronavirus disease COVID-19 COVID-19 knowledge COVID-19 patient COVID-19 treatment demonstrated disease drug drug combination drug combinations Drug development Drug repurposing drugs Efficacy Evidence facilitate FDA approval Genetic highlight host genes in vitro integration Interaction interactions Knowledge graph Novel coronavirus novel coronavirus disease outbreak pandemic Pathways Phenotypes profiles Research Treatment Virtual screening virus was used [DOI] 10.1038/s41598-021-02353-5 PMC 바로가기 [Article Type] Article
Effect of Ivermectin and Atorvastatin on Nuclear Localization of Importin Alpha and Drug Target Expression Profiling in Host Cells from Nasopharyngeal Swabs of SARS-CoV-2- Positive PatientsSARS-COV-2- 양성 환자의 비 인두 면봉으로부터의 숙주 세포에서 수입 알파 및 약물 표적 발현 프로파일 링에 대한 Ivermectin 및 Atorvastatin의 효과Article Published on 2021-10-152022-09-10 Journal: Viruses [Category] SARS, 신약개발, 유전자 메커니즘, 치료법, 치료제, [키워드] Actin Affect alteration analyzed antihelmintic drug atorvastatin Cdc42 cellular Combination concentrations confocal microscopy COVID-19 COVID-19 patient COVID-19 patients cytoplasmic distribution drug Drug repurposing drug target drugs Effect expression function Gene Expression host cell host cell antiviral response host cells impair Importin in vitro model Infection inhibit involved Ivermectin KPNA3 KPNA5 KPNA7 KPNB1 lipophilic statin Localization mechanism Nasopharyngeal swab nasopharyngeal swabs NF-κB NF-κB activation Non-COVID-19 patients nuclear Nuclear localization Pathogenesis Patient pleiotropic effect poly(I:C) Profiling Result Rho GTPase Rho GTPases RHOA RNA viruses SARS-CoV-2 SARS-COV-2 infection Signaling target transcriptional Transport Treatment triggered Vesicle Viral viral double-stranded RNA [DOI] 10.3390/v13102084 PMC 바로가기 [Article Type] Article
Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry데이터 기반 접근 방식과 SARS-CoV-2 진입의 폐 오르가노이드 모델을 사용하여 COVID-19에 대한 다중 모드 특성을 가진 FDA 승인 약물 식별Research Article Published on 2021-09-092022-09-10 Journal: Molecular Medicine [Category] SARS, 신약개발, 치료제, [키워드] analyses approach atorvastatin chemoinformatics Clinical studies clinical study combined treatment Compound Connectivity mapping correlated COVID-19 data-driven database docking drug drug repositioning Drug screening Drug testing Effect FDA-approved drug FDA-approved drugs identify identifying individual Infection inhibit less lung lung organoids molecular docking pandemic Pandemics predicted Prophylactic protease protective effect Protective effects reported Result RNA-dependent RNA polymerase Safe SARS-CoV-2 entry shown spread of COVID-19 statin supplementary material transcriptional change Transcriptional changes transcriptomic vaccine availability Viral viral entry with infection [DOI] 10.1186/s10020-021-00356-6 PMC 바로가기 [Article Type] Research Article
A randomized open-label trial to evaluate the efficacy and safety of triple therapy with aspirin, atorvastatin, and nicorandil in hospitalised patients with SARS Cov-2 infection: A structured summary of a study protocol for a randomized controlled trialSARS Cov-2 감염으로 입원한 환자에서 아스피린, 아토르바스타틴, 니코란딜을 사용한 삼중 요법의 효능과 안전성을 평가하기 위한 무작위 공개 시험: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-07-152022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 ACHE Acute coronary syndrome Acute kidney injury acute renal failure adequate hydration adjuvant therapy Admission allergy ALT/AST Altered mental status Anti-inflammatory anticoagulation antipyretics Antithrombotic approved ARDS Aspirin AST/ALT atorvastatin bleeding Blinding block randomization Breastfeeding brown urine change characterized clinical clinical feature Clinical features Coagulopathy college Combination comorbid condition comorbid conditions comparator conducted control group coronary syndrome Corticosteroid Corticosteroids cough COVID-19 CPK creatine creatine kinase creatinine CRP current therapy Dexamethasone dissemination dose drug dysfunction Dyspnoea dysregulation effective Efficacy and safety element Endothelial dysfunction enrolled ethical committee evaluate excluded ferritin Fever followed by greater heparin hepatotoxicity Hospital admission hospital discharge Hospital mortality Hospital stay hospitalised patient Hospitalised patients hyperbilirubinemia hypoxia ICMR IEC immune dysregulation immunomodulatory impaired consciousness in-hospital mortality India Inflammation Inflammatory marker inflammatory markers Intervention intervention group intolerance intravenous Intravenous remdesivir invasive limit liver low molecular weight low molecular weight heparin management marker mechanical ventilation medication medications moderate muscle ache myalgia Myoglobin Myopathy myositis national guidelines Nicorandil Non-invasive number objective once daily Open-label open-label trial outcome oxygen Oxygen requirement oxygen support participant pathophysiologic pathophysiology Patient Platelet Platelet count Pneumonia positive Pregnancy Primary outcome progression protocol raised Rajendra Prasad Randomised control trial randomization randomize Randomized Randomized controlled trial randomly divided receive recruitment reducing mortality Registered registry Remdesivir renal failure reported respiratory rate rhabdomyolysis room air RT-PCR safety endpoint safety endpoints Sample size SARS-CoV-2 infected patient SARS-COV-2 infection Schematic screened Secondary outcomes Sepsis serum serum markers severe disease Shock significant interaction SpO2 Standard Standard of care starting dose statin statins Study design Study protocol substrates supplementary material Symptom Symptomatic treatment Tablet therapeutic therapeutic agent therapy thrombocytopenia Treatment Trial Trial registration two-arm parallel ULN Urine weakness website [DOI] 10.1186/s13063-021-05361-y PMC 바로가기 [Article Type] Letter