Neuropsychiatric Ramifications of COVID-19: Short-Chain Fatty Acid Deficiency and Disturbance of Microbiota-Gut-Brain Axis SignalingReview Article Published on 2021-10-052022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, SARS, [키워드] accompanied ACE-2 acid alleviate Altered Anti-inflammatory anti-inflammatory function axis Bacteria binding Brain changes in characterized commensal bacteria Complication components contribute COVID-19 COVID-19 patient Critical decrease deficiency described diagnostic disorders disturbance evaluate fatty favor fecal fiber gastrointestinal symptoms Gut gut microbiota gut microbiota composition implicated increase in Inflammation metabolite microbial Neurological disorder Neuropsychiatric Pathogens Prevent producing proinflammatory Psychiatric ramification receptor recommendation Research risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptors SCFA signaling pathway supported systemic inflammation Transport turn viral presence [DOI] 10.1155/2021/7880448 PMC 바로가기 [Article Type] Review Article
Molecular Insights into SARS-CoV2-Induced Alterations of the Gut/Brain Axis장/뇌 축의 SARS-CoV2 유발 변형에 대한 분자적 통찰력Article Published on 2021-09-282022-09-12 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] Absorption ACE2 alteration alterations Amino acid amino acids Analysis angiotensin axis Brain cells chronic infection co-expression coding cognitive COVID COVID-19 DDC develop disorder disorders dopa Dopamine Enterocyte enterocytes enzyme Express expression expression level extreme fatigue highest host receptor Inflammation insight Intestinal Organoids involved L-DOPA Long COVID long-lasting metabolic pathway metabolism monoamine oxidase Neuropsychiatric Neurotransmitters Neutral pathway Patient performed precursor precursors reported responsible RNA-seq data SARS-CoV2 small intestine Symptom tissue tissues trace amines [DOI] 10.3390/ijms221910440 PMC 바로가기 [Article Type] Article
A Potential Role of the CD47/SIRPalpha Axis in COVID-19 PathogenesisCovid-19 병인에서 CD47/Sirpalpha 축의 잠재적 역할Article Published on 2021-09-222022-08-31 Journal: Curr Issues Mol Biol [Category] SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] Acute kidney injury addressed Air-liquid interface antibody Antiviral antiviral therapy Asymptomatic axis binding bronchial epithelial cells Caco-2 Caco-2 cells Calu calu-3 cells Cancer caused CD47 condition contribute contributing to coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 pandemic COVID-19 pathology COVID-19 research COVID-19-related complication COVID-19-related complications Culture develop diabete diabetes disease elevated epithelial cells expression Factor fibrosis fraction group hyperinflammation hypertension IAP Immune escape immune response increase indicated individual infected cells infected individual infected individuals life-threatening Lung fibrosis mechanism Mild Monocytes MOST myocardial injury Older age Potential primary human bronchial epithelial cells primary human monocytes pulmonary hypertension Research resulting risk factor role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2-infected individual SARS-CoV-2-infected individuals severe COVID-19 severe disease SIRPalpha Small molecules stroke therapeutic target vascular disease vasoconstriction virus-infected cells [DOI] 10.3390/cimb43030086 PMC 바로가기 [Article Type] Article
Evaluating the Role of the Interleukin-23/17 Axis in Critically Ill COVID-19 PatientsCommunication Published on 2021-09-072022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] Admission axis circulating comparable coronavirus disease Corticosteroids COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients COVID-19 severity Critical Critically ill Cytokines enrolled Evaluating groups ICU ICU admission IL-17 IL-23 Ill Illness severity inhibiting intensive care Non-COVID-19 non-COVID-19 patient Non-COVID-19 patients Patient patients hospitalized personalized treatment role Sepsis Septic shock Support undetectable used to evaluate were measured [DOI] 10.3390/jpm11090891 PMC 바로가기 [Article Type] Communication
ACE2, the Counter-Regulatory Renin–Angiotensin System Axis and COVID-19 SeverityReview Published on 2021-08-292022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE2 ACE2 expression acute respiratory syndrome amplification ANG angiotensin appear axis benefit cause clinical implication contribute coronavirus coronavirus disease COVID-19 COVID-19 severity deviation entry receptor enzyme inhibitor lung manuscript occur other organ pathway Protective RAASi RAS recent renin–angiotensin system risk Risk factors SARS-CoV-2 severe disease suggested System the SARS-CoV-2 upregulation [DOI] 10.3390/jcm10173885 PMC 바로가기 [Article Type] Review
The SARS-CoV-2/Receptor Axis in Heart and Blood Vessels: A Crisp Update on COVID-19 Disease with Cardiovascular Complications심장 및 혈관의 SARS-COV-2/수용체 축 : 심혈관 합병증을 가진 COVID-19 질병에 대한 선명한 업데이트Review Published on 2021-07-122022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] ACE2 receptor ACE2 receptors Activation association attribute attributes axis binding Blood blood vessel blood vessels bradykinin cardiovascular cardiovascular complication cardiovascular complications cardiovascular disease chronic condition chronic conditions complement Complication components COVID-19 COVID-19 disease Defense described detrimental disease dysfunction Effect Effects endothelial Endothelial dysfunction expression pattern function glycocalyx Health Organization heart Host host defense immune cell response immune cell responses mechanism organ pandemic Patient patient with COVID-19 Platelets potential molecular provide receptor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus the patient thrombosis vascular leakage vessel vessels WHO World Health Organization [DOI] 10.3390/v13071346 PMC 바로가기 [Article Type] Review
The Activin/Follistatin Axis Is Severely Deregulated in COVID-19 and Independently Associated With In-Hospital Mortality액티빈/폴리스타틴 축은 COVID-19에서 심각하게 규제가 완화되고 병원 내 사망률과 독립적으로 연관됩니다Article Published on 2021-05-202022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커, 진단, [키워드] 95% confidence interval activin Activins Admission age analyzed AUC values axis C-reactive protein cause clinical decision Comorbidities coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 COVID-19 mortality COVID-19 patient D-dimers Decision making deregulated disease disorders feature follistatin growth Hospitalized implicated independent indicated inhibitor intensive care intensive care unit admission Laboratory parameters Lactate lactate dehydrogenase lung Mortality murine neutrophil neutrophil/lymphocyte ratio outcome overexpression Pathogenesis pathology pathophysiology predicted previous study SARS-CoV-2 scoring system serum sample serum samples severity significantly transforming growth factor validation cohort variable was used [DOI] 10.1093/infdis/jiab108 PMC 바로가기 [Article Type] Article
Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질에 의해 인식이 변경된 인간 ACE2 변이체의 발견Research Article Published on 2021-05-122022-09-10 Journal: PLoS ONE [Category] SARS, 변종, [키워드] ACE2 ACE2 residue ACE2 residues ACE2 sequence Analysis axis Clinical trial design complementary COVID-19 epidemiological facilitate Genetic variant human ACE2 identify Interaction mutant Recognition Research SARS-CoV-2 single-nucleotide SNVs Spike protein strain the SARS-CoV-2 understanding utility variant virus [DOI] 10.1371/journal.pone.0251585 PMC 바로가기 [Article Type] Research Article
From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 PathogenesisReview Article Published on 2021-04-162022-10-31 Journal: Mediators of Inflammation [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 expression Affect affected angiotensin-converting enzyme-2 antiviral immune responses axis bidirectional contribute cross-talk demonstrated dendritic cell Effect Efficacy expression gut microbiota composition healthy individuals homing Host immune response immune system infected with SARS-CoV-2 Inflammation lung lymphocyte main receptor microbiota outbreak Patient regulate reported respiratory infections responsible role SARS-CoV-2 shown the gut-lung axis Therapeutic approach Vaccine viral respiratory infection [DOI] 10.1155/2021/6611222 PMC 바로가기 [Article Type] Review Article
SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human MicrogliaImmunology Published on 2021-04-142022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] addition Anomaly association axis bystander catastrophic CNS COVID-19 COVID-19 case declining deubiquitinase distress downstream dysfunction Exosome Exosomes explain expression gene product Host Host immune response Human Hyperactivation IFN-β immune cascade IRF9 knowledge microglia microRNA modify mRNA nervous Neuroinflammation neurological NF-κB Novel coronavirus infection organ pathway patients pro-inflammatory gene expression Protein provide regulate Replication SARS-CoV-2 shown Specific spike spike gene supported suppress syndrome System target target gene tissue TNFα transfected cell transported ubiquitin uninfected USP33 Vaccine Viral load virus [DOI] 10.3389/fimmu.2021.656700 PMC 바로가기 [Article Type] Immunology